Chorioallantoic urothelial tumor avatar: a clinical tool for phenotype-based therapy
Ossick, Marina Vian; Ferrari, Karen Linares; Nunes-Silva, Igor; Denardi, Fernandes; Reis, Leonardo Oliveira.
Acta cir. bras.;
34(12): e201901207, 2019. ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-24526
Resumo
In the muscle invasive bladder cancer (MIBC) standard of care treatment only patients presenting a major pathological tumor response are more likely to show the established modest 5% absolute survival benefit at 5 years after cisplatin-based neoadjuvant chemotherapy (NAC). To overcome the drawbacks of a blind NAC (i.e. late cystectomy with unnecessary NAC adverse events) with potential to survival improvements, preclinical models of urothelial carcinoma have arisen in this generation as a way to pre-determine drug resistance even before therapy is targeted. The implantation of tumor specimens in the chorioallantoic membrane (MCA) of the chicken embryo results in a high-efficiency graft, thus allowing large-scale studies of patient-derived tumor avatar. This article discusses a novel approach that exploits cancer multidrug resistance to provide personalized phenotype-based therapy utilizing the MIBC NAC dilemma.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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