Soybean -conglycinin Induces Intestinal Immune Responses in Chicks
Kang, D. R; Belal, S. A; Song, K. D; Yoon, C; Park, B. Y; Shim, K. S.
R. bras. Ci. avíc.;
22(2): eRBCA-2018-0798, 2020. ilus, tab, graf
Artigo
em Inglês
| VETINDEX
| ID: vti-27225
Resumo
Conglycinin from soybean has been recognized as one of the major feed allergens. This study investigated the effects of -conglycinin-induced allergic sensitization on chicks small intestines. A total of 40 7-day-old (100 g) chicks were divided into four groups as control, -conglycinin 1 h, -conglycinin 6 h, and -conglycinin 12 h. All treatment groups were administered 60 mg of -conglycinin/chick and small intestine samples were collected. -conglycinin-induced allergic sensitization marginally damages the epithelium lining of the duodenum villi and, in addition, significantly increases the accumulation of mast cells in the lamina propria and crypt of the duodenum. Moreover, the TNF- level significantly increased in all -conglycinin groups. IL-8 and IL-2 were significantly downregulated in the 1 h group; however, there were increases for the 6 h and 12 h groups. These results suggest that -conglycinin may lead to an inflammatory response in the chicks small intestines.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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