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Live bacterial vaccine vectors: An overview
Silva, Adilson José da; Zangirolami, Teresa Cristina; Novo-Mansur, Maria Teresa Marques; Giordano, Roberto de Campos; Martins, Elizabeth Angélica Leme.
Afiliação
  • Silva, Adilson José da; Universidade Federal de São Carlos. Departamento de Engenharia Química. São Carlos. BR
  • Zangirolami, Teresa Cristina; Universidade Federal de São Carlos. Departamento de Engenharia Química. São Carlos. BR
  • Novo-Mansur, Maria Teresa Marques; Universidade Federal de São Carlos. Departamento de Engenharia Química. São Carlos. BR
  • Giordano, Roberto de Campos; Universidade Federal de São Carlos. Departamento de Engenharia Química. São Carlos. BR
  • Martins, Elizabeth Angélica Leme; Universidade Federal de São Carlos. Departamento de Engenharia Química. São Carlos. BR
Braz. J. Microbiol. ; 45(4): 1117-1129, Oct.-Dec. 2014. tab
Article em En | VETINDEX | ID: vti-27416
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enables the use of different forms of vaccination to prevent pathogen colonization of mucosal tissues, the front door for many infectious agents. Furthermore, delivery of DNA vaccines and immune system stimulatory molecules, such as cytokines, can be achieved using these special carriers, whose adjuvant properties and, sometimes, invasive capacities enhance the immune response. More recently, the unique features and versatility of these vectors have also been exploited to develop anti-cancer vaccines, where tumor-associated antigens, cytokines, and DNA or RNA molecules are delivered. Different strategies and genetic tools are constantly being developed, increasing the antigenic potential of agents delivered by these systems, opening fresh perspectives for the deployment of vehicles for new purposes. Here we summarize the main characteristics of the different types of live bacterial vectors and discuss new applications of these delivery systems in the field of vaccinology.
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Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Braz. J. Microbiol. Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: Braz. J. Microbiol. Ano de publicação: 2014 Tipo de documento: Article