Evaluation of wound healing effect of alginate film containing aloe vera gel and cross-linked with zinc chloride
Koga, Adriana Yuriko; Felix, Julio César; Silvestre, Rodrigo Gomes Marques; Lipinski, Leandro Cavalcante; Carletto, Bruna; Kawahara, Fernanda Alexia; Pereira, Airton Vicente.
Acta cir. bras.;
35(5): e202000507, July 3, 2020. ilus, graf
Artigo
em Inglês
| VETINDEX
| ID: vti-28953
Resumo
Purpose To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. Methods The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. Results The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. Conclusions The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The in vivo assay demonstrated that aloe-alginate film enhanced the healing process of incisional skin wounds.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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