Brazilian propolis protects Saccharomyces cerevisiae cells against oxidative stress
Sá, Rafael A de; Castro, Frederico A V de; Eleutherio, Elis C A; Souza, Raquel M de; Silva, Joaquim F M da; Pereira, Marcos D.
Braz. J. Microbiol.;
44(3): 993-1000, July-Sept. 2013.
Artigo
em Inglês
| VETINDEX
| ID: vti-304319
Resumo
Propolis is a natural product widely used for humans. Due to its complex composition, a number of applications (antimicrobial, antiinflammatory, anesthetic, cytostatic and antioxidant) have been attributed to this substance. Using Saccharomyces cerevisiae as a eukaryotic model we investigated the mechanisms underlying the antioxidant effect of propolis from Guarapari against oxidative stress. Submitting a wild type (BY4741) and antioxidant deficient strains (ctt1, sod1, gsh1, gtt1 and gtt2) either to 15 mM menadione or to 2 mM hydrogen peroxide during 60 min, we observed that all strains, except the mutant sod1, acquired tolerance when previously treated with 25 µg/mL of alcoholic propolis extract. Such a treatment reduced the levels of ROS generation and of lipid peroxidation, after oxidative stress. The increase in Cu/Zn-Sod activity by propolis suggests that the protection might be acting synergistically with Cu/Zn-Sod.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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