Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
Melo, Nayanna de Oliveira Ramos; Juanes, Camila de Carvalho; Alves, Mayara Freire de Alencar; Silva, Emiliano Tiago Melo; Jamacaru, Francisco Vagnaldo Fechine; Lemos, Telma Leda Gomes de; Dornelas, Conceição Aparecida.
Acta cir. bras.;
33(5): 420-430, May 2018. ilus, tab, graf
Artigo
em Inglês
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| ID: vti-734711
Resumo
Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E). Results: In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001). Conclusion: Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.(AU)
Biblioteca responsável:
BR68.1
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