Detalhe da pesquisa
1.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Bioorg Med Chem Lett
; 60: 128549, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041943
2.
Dimethyl fumarate treatment shifts the immune environment toward an anti-inflammatory cell profile while maintaining protective humoral immunity.
Mult Scler
; 27(6): 883-894, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32716690
3.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 44: 116275, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314938
4.
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Bioorg Med Chem
; 27(13): 2905-2913, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31138459
5.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35728998
6.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
7.
Immunogenicity Risk Assessment for Multi-specific Therapeutics.
AAPS J
; 23(6): 115, 2021 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34741215
8.
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Clin Transl Immunology
; 10(6): e1295, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141433
9.
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
J Med Chem
; 63(21): 12526-12541, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696648
10.
Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice.
Neurology
; 92(15): e1724-e1738, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30918100
11.
2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62).
Bioanalysis
; 11(24): 2207-2244, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820675