Detalhe da pesquisa
1.
Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.
J Neurosci
; 34(42): 14069-78, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25319703
2.
C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.
Proc Natl Acad Sci U S A
; 108(10): 4236-41, 2011 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21368138
3.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Neuron
; 112(3): 384-403.e8, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37995685
4.
Reducing human apolipoprotein E levels attenuates age-dependent Aß accumulation in mutant human amyloid precursor protein transgenic mice.
J Neurosci
; 32(14): 4803-11, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22492035
5.
ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease.
Neurocase
; 19(3): 295-301, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22512241
6.
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Neuron
; 55(5): 697-711, 2007 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17785178
7.
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
J Neurosci
; 30(41): 13707-17, 2010 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20943911
8.
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
Nat Med
; 10(11): 1190-2, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15502844
9.
APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function.
Sci Transl Med
; 13(581)2021 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33597265
10.
Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.
J Neurosci
; 27(11): 2727-33, 2007 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17360894
11.
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
J Clin Invest
; 128(5): 2144-2155, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29600961
12.
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
J Neurosci
; 26(19): 5167-79, 2006 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16687508
13.
Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.
J Neurosci
; 25(42): 9686-93, 2005 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16237173
14.
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
J Neurosci
; 25(42): 9694-703, 2005 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16237174
15.
Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.
Toxicol Sci
; 152(1): 72-84, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27103662
16.
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.
Neuron
; 89(1): 70-82, 2016 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26687840
17.
Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis.
Biochem J
; 379(Pt 2): 385-93, 2004 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14713286
18.
Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.
Neuron
; 88(2): 289-97, 2015 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26494278
19.
Dissecting gene expression at the blood-brain barrier.
Front Neurosci
; 8: 355, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25414634
20.
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.
J Exp Med
; 211(2): 233-44, 2014 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24470444