Detalhe da pesquisa
1.
Bioinformatics pipeline to guide post-GWAS studies in Alzheimer's: A new catalogue of disease candidate short structural variants.
Alzheimers Dement
; 19(9): 4094-4109, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37253165
2.
The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.
Hum Mol Genet
; 29(18): 3107-3121, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32954426
3.
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
Am J Hum Genet
; 105(2): 334-350, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31374203
4.
The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.
Mol Ther
; 29(3): 949-972, 2021 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33429080
5.
Multiplication of the SNCA locus exacerbates neuronal nuclear aging.
Hum Mol Genet
; 28(3): 407-421, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30304516
6.
APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer's.
Int J Mol Sci
; 22(3)2021 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33513969
7.
Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.
Alzheimers Dement
; 16(9): 1280-1292, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32588970
8.
Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
Mol Ther
; 26(11): 2638-2649, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30266652
9.
Bioinformatics strategy to advance the interpretation of Alzheimer's disease GWAS discoveries: The roads from association to causation.
Alzheimers Dement
; 15(8): 1048-1058, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31262699
10.
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
Twin Res Hum Genet
; 21(5): 394-397, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30001766
11.
The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes.
Alzheimers Dement
; 14(5): 692-698, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29524426
12.
The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster.
Biochim Biophys Acta Mol Basis Dis
; 1863(3): 810-816, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28065845
13.
Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.
Alzheimers Dement
; 13(11): 1237-1250, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431219
14.
The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants.
Hum Mutat
; 37(9): 877-83, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27279261
15.
The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.
Hum Mol Genet
; 23(18): 4814-21, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24777780
16.
A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.
Alzheimers Dement
; 11(10): 1133-43, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26079410
17.
The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.
Alzheimers Dement
; 10(5): 541-51, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24439168
18.
African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.
Alzheimers Dement
; 10(6): 592-601.e2, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25260913
19.
Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathies.
Mol Ther Nucleic Acids
; 35(1): 102084, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38130373
20.
All-in-one AAV-delivered epigenome-editing platform: proof-of-concept and therapeutic implications for neurodegenerative disorders.
bioRxiv
; 2024 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798630