Detalhe da pesquisa
1.
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
J Biol Chem
; 292(43): 17963-17974, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28860188
2.
A novel fluorogenic substrate for the measurement of endothelial lipase activity.
J Lipid Res
; 52(2): 374-82, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21062953
3.
Enhancing recombinant protein quality and yield by protein stability profiling.
J Biomol Screen
; 12(3): 418-28, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17438070
4.
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.
J Med Chem
; 48(4): 909-12, 2005 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15715460
5.
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution.
Protein Sci
; 20(4): 670-83, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21308848
6.
Potency variation of small-molecule chymase inhibitors across species.
Biochem Pharmacol
; 80(7): 1033-41, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20599788
7.
Structural basis for elastolytic substrate specificity in rodent alpha-chymases.
J Biol Chem
; 283(1): 427-436, 2008 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17981788
8.
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
J Biol Chem
; 282(6): 4094-101, 2007 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17132624
9.
Protein engineering of the colony-stimulating factor-1 receptor kinase domain for structural studies.
J Biol Chem
; 282(6): 4085-93, 2007 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17132625
10.
Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.
Arch Biochem Biophys
; 449(1-2): 47-56, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16620770
11.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(1): 123-8, 2006 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16236500
12.
Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives.
Biochemistry
; 45(17): 5678-85, 2006 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16634649
13.
Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
Bioorg Med Chem Lett
; 12(3): 491-5, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11814826