Detalhe da pesquisa
1.
Verinurad does not prolong QTc interval: a thorough QT study using concentration-QTc modelling.
Br J Clin Pharmacol
; 89(6): 1747-1755, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36504291
2.
AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval.
Br J Clin Pharmacol
; 88(11): 4839-4844, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653229
3.
Concentration-QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations.
Br J Clin Pharmacol
; 88(2): 858-864, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34309049
4.
Concentration-QT modelling in early clinical oncology settings: Simulation evaluation of performance.
Br J Clin Pharmacol
; 88(3): 1010-1019, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416045
5.
The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".
Ann Noninvasive Electrocardiol
; 19(1): 70-81, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24372708
6.
The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses.
Pharmacol Res Perspect
; 12(2): e1184, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38445541
7.
Assessment of ventricular repolarization variability with the DeltaT50 method improves identification of patients with congenital long QT syndromes.
Ann Noninvasive Electrocardiol
; 18(3): 240-50, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23714082
8.
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.
Cancer Chemother Pharmacol
; 92(2): 141-150, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37368100
9.
DeltaT50--a new method to assess temporal ventricular repolarization variability.
J Electrocardiol
; 44(4): 477.e1-9, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21704223
10.
QT Prolongation Risk Assessment in Oncology: Lessons Learned From Small-Molecule New Drug Applications Approved During 2011-2019.
J Clin Pharmacol
; 61(8): 1106-1117, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33624833
11.
A Randomized, Double-Blind, Placebo- and Positive-Controlled, Three-Way Crossover Study in Healthy Participants to Investigate the Effect of Savolitinib on the QTc Interval.
Clin Pharmacol Drug Dev
; 10(5): 521-534, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33400845
12.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
13.
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
J Clin Pharmacol
; 60(1): 125-139, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31378962
14.
PC-Based ECG waveform recognition-validation of novel software against a reference ECG database.
Ann Noninvasive Electrocardiol
; 14 Suppl 1: S42-7, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19143742
15.
Can Bias Evaluation Provide Protection Against False-Negative Results in QT Studies Without a Positive Control Using Exposure-Response Analysis?
J Clin Pharmacol
; 57(1): 85-95, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27271102
16.
An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data.
Toxicol Sci
; 159(1): 94-101, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28903488
17.
Olaparib does not cause clinically relevant QT/QTc interval prolongation in patients with advanced solid tumours: results from two phase I studies.
Cancer Chemother Pharmacol
; 78(4): 775-84, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27553432
18.
Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.
Ann Noninvasive Electrocardiol
; 7(4): 289-301, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12431306
19.
Inter- and intraday variability in major electrocardiogram intervals and amplitudes in healthy men and women.
Pacing Clin Electrophysiol
; 26(1P2): 361-6, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12687846