Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.

Cheong, Jin-Gyu; Ravishankar, Arjun; Sharma, Siddhartha; Parkhurst, Christopher N; Grassmann, Simon A; Wingert, Claire K; Laurent, Paoline; Ma, Sai; Paddock, Lucinda; Miranda, Isabella C; Karakaslar, Emin Onur; Nehar-Belaid, Djamel; Thibodeau, Asa; Bale, Michael J; Kartha, Vinay K; Yee, Jim K; Mays, Minh Y; Jiang, Chenyang; Daman, Andrew W; Martinez de Paz, Alexia; Ahimovic, Dughan; Ramos, Victor; Lercher, Alexander; Nielsen, Erik; Alvarez-Mulett, Sergio; Zheng, Ling; Earl, Andrew; Yallowitz, Alisha; Robbins, Lexi; LaFond, Elyse; Weidman, Karissa L; Racine-Brzostek, Sabrina; Yang, He S; Price, David R; Leyre, Louise; Rendeiro, André F; Ravichandran, Hiranmayi; Kim, Junbum; Borczuk, Alain C; Rice, Charles M; Jones, R Brad; Schenck, Edward J; Kaner, Robert J; Chadburn, Amy; Zhao, Zhen; Pascual, Virginia; Elemento, Olivier; Schwartz, Robert E; Buenrostro, Jason D; Niec, Rachel E.

Cell ; 186(18): 3882-3902.e24, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37597510

2.

Deconvoluting global cytokine signaling networks in natural killer cells.

Wiedemann, Gabriela M; Santosa, Endi K; Grassmann, Simon; Sheppard, Sam; Le Luduec, Jean-Benoît; Adams, Nicholas M; Dang, Celeste; Hsu, Katharine C; Sun, Joseph C; Lau, Colleen M.

Nat Immunol ; 22(5): 627-638, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33859404

3.

Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.

Hiltensperger, Michael; Beltrán, Eduardo; Kant, Ravi; Tyystjärvi, Sofia; Lepennetier, Gildas; Domínguez Moreno, Helena; Bauer, Isabel J; Grassmann, Simon; Jarosch, Sebastian; Schober, Kilian; Buchholz, Veit R; Kenet, Selin; Gasperi, Christiane; Öllinger, Rupert; Rad, Roland; Muschaweckh, Andreas; Sie, Christopher; Aly, Lilian; Knier, Benjamin; Garg, Garima; Afzali, Ali M; Gerdes, Lisa Ann; Kümpfel, Tania; Franzenburg, Sören; Kawakami, Naoto; Hemmer, Bernhard; Busch, Dirk H; Misgeld, Thomas; Dornmair, Klaus; Korn, Thomas.

Nat Immunol ; 22(7): 880-892, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34099917

4.

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection.

Grassmann, Simon; Mihatsch, Lorenz; Mir, Jonas; Kazeroonian, Atefeh; Rahimi, Roza; Flommersfeld, Sophie; Schober, Kilian; Hensel, Inge; Leube, Justin; Pachmayr, Ludwig O; Kretschmer, Lorenz; Zhang, Qin; Jolly, Adrien; Chaudhry, M Zeeshan; Schiemann, Matthias; Cicin-Sain, Luka; Höfer, Thomas; Busch, Dirk H; Flossdorf, Michael; Buchholz, Veit R.

Nat Immunol ; 21(12): 1563-1573, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33106669

5.

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection.

Schober, Kilian; Voit, Florian; Grassmann, Simon; Müller, Thomas R; Eggert, Joel; Jarosch, Sebastian; Weißbrich, Bianca; Hoffmann, Patrick; Borkner, Lisa; Nio, Enzo; Fanchi, Lorenzo; Clouser, Christopher R; Radhakrishnan, Aditya; Mihatsch, Lorenz; Lückemeier, Philipp; Leube, Justin; Dössinger, Georg; Klein, Ludger; Neuenhahn, Michael; Oduro, Jennifer D; Cicin-Sain, Luka; Buchholz, Veit R; Busch, Dirk H.

Nat Immunol ; 21(4): 434-441, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32205883

6.

Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection.

Straub, Adrian; Grassmann, Simon; Jarosch, Sebastian; Richter, Lena; Hilgendorf, Philipp; Hammel, Monika; Wagner, Karolin I; Buchholz, Veit R; Schober, Kilian; Busch, Dirk H.

Immunity ; 56(6): 1269-1284.e6, 2023 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-37164014

7.

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.

Bayerl, Felix; Meiser, Philippa; Donakonda, Sainitin; Hirschberger, Anna; Lacher, Sebastian B; Pedde, Anna-Marie; Hermann, Chris D; Elewaut, Anais; Knolle, Moritz; Ramsauer, Lukas; Rudolph, Thomas J; Grassmann, Simon; Öllinger, Rupert; Kirchhammer, Nicole; Trefny, Marcel; Anton, Martina; Wohlleber, Dirk; Höchst, Bastian; Zaremba, Anne; Krüger, Achim; Rad, Roland; Obenauf, Anna C; Schadendorf, Dirk; Zippelius, Alfred; Buchholz, Veit R; Schraml, Barbara U; Böttcher, Jan P.

Immunity ; 56(6): 1341-1358.e11, 2023 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-37315536

8.

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.

Flommersfeld, Sophie; Böttcher, Jan P; Ersching, Jonatan; Flossdorf, Michael; Meiser, Philippa; Pachmayr, Ludwig O; Leube, Justin; Hensel, Inge; Jarosch, Sebastian; Zhang, Qin; Chaudhry, M Zeeshan; Andrae, Immanuel; Schiemann, Matthias; Busch, Dirk H; Cicin-Sain, Luka; Sun, Joseph C; Gasteiger, Georg; Victora, Gabriel D; Höfer, Thomas; Buchholz, Veit R; Grassmann, Simon.

Immunity ; 54(10): 2288-2304.e7, 2021 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-34437840

9.

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

Afzali, Ali Maisam; Nirschl, Lucy; Sie, Christopher; Pfaller, Monika; Ulianov, Oleksii; Hassler, Tobias; Federle, Christine; Petrozziello, Elisabetta; Kalluri, Sudhakar Reddy; Chen, Hsin Hsiang; Tyystjärvi, Sofia; Muschaweckh, Andreas; Lammens, Katja; Delbridge, Claire; Büttner, Andreas; Steiger, Katja; Seyhan, Gönül; Ottersen, Ole Petter; Öllinger, Rupert; Rad, Roland; Jarosch, Sebastian; Straub, Adrian; Mühlbauer, Anton; Grassmann, Simon; Hemmer, Bernhard; Böttcher, Jan P; Wagner, Ingrid; Kreutzfeldt, Mario; Merkler, Doron; Pardàs, Irene Bonafonte; Schmidt Supprian, Marc; Buchholz, Veit R; Heink, Sylvia; Busch, Dirk H; Klein, Ludger; Korn, Thomas.

Nature ; 627(8003): 407-415, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38383779

10.

Thanks for the NK cell memories.

Grassmann, Simon; Sun, Joseph C.

Nat Immunol ; 23(11): 1512-1514, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36289448

11.

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.

Grassmann, Simon; Pachmayr, Ludwig O; Leube, Justin; Mihatsch, Lorenz; Andrae, Immanuel; Flommersfeld, Sophie; Oduro, Jennifer; Cicin-Sain, Luka; Schiemann, Matthias; Flossdorf, Michael; Buchholz, Veit R.

Immunity ; 50(6): 1391-1400.e4, 2019 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-31103380

12.

Unbiased chemokine receptor screening reveals similar efficacy of lymph node- and tumor-targeted T cell immunotherapy.

Pachmayr, Ludwig O; Muehlbauer, Anton; Flommersfeld, Sophie; Graml, Franziska; Hoenninger, Julian; von Baumgarten, Louisa; Buchholz, Veit R; Grassmann, Simon.

Cancer Immunol Immunother ; 72(9): 3111-3124, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37301772

13.

Single-Cell Profiling Reveals a Naive-Memory Relationship between CD56 ^bright and Adaptive Human Natural Killer Cells.

Panjwani, M Kazim; Grassmann, Simon; Sottile, Rosa; Le Luduec, Jean-Benoît; Kontopoulos, Theodota; van der Ploeg, Kattria; Sun, Joseph C; Hsu, Katharine C.

bioRxiv ; 2023 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-37790504

14.

Early antigen receptor signaling in natural killer cells alters STAT4-dependent fate decisions via epigenetic remodeling.

Grassmann, Simon; Santosa, Endi K; Mujal, Adriana M; Kim, Hyunu; Fan, Sherry X; Owyong, Mark; Lau, Colleen M; Sun, Joseph C.

bioRxiv ; 2023 Nov 09.

Artigo em Inglês | MEDLINE | ID: mdl-37986752

15.

Retrogenic Color-Barcoding for Fate Mapping of Single Innate Lymphocytes.

Grassmann, Simon; Sun, Joseph C; Buchholz, Veit R.

Methods Mol Biol ; 2463: 117-127, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35344171

16.

Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity.

Purcarea, Anna; Jarosch, Sebastian; Barton, Jack; Grassmann, Simon; Pachmayr, Ludwig; D'Ippolito, Elvira; Hammel, Monika; Hochholzer, Anna; Wagner, Karolin I; van den Berg, Joost H; Buchholz, Veit R; Haanen, John B A G; Busch, Dirk H; Schober, Kilian.

Sci Immunol ; 7(74): eabm2077, 2022 08 12.

Artigo em Inglês | MEDLINE | ID: mdl-35960818

17.

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.

Müller, Thomas R; Jarosch, Sebastian; Hammel, Monika; Leube, Justin; Grassmann, Simon; Bernard, Bettina; Effenberger, Manuel; Andrä, Immanuel; Chaudhry, M Zeeshan; Käuferle, Theresa; Malo, Antje; Cicin-Sain, Luka; Steinberger, Peter; Feuchtinger, Tobias; Protzer, Ulrike; Schumann, Kathrin; Neuenhahn, Michael; Schober, Kilian; Busch, Dirk H.

Cell Rep Med ; 2(8): 100374, 2021 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-34467251

18.

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Lesch, Stefanie; Blumenberg, Viktoria; Stoiber, Stefan; Gottschlich, Adrian; Ogonek, Justyna; Cadilha, Bruno L; Dantes, Zahra; Rataj, Felicitas; Dorman, Klara; Lutz, Johannes; Karches, Clara H; Heise, Constanze; Kurzay, Mathias; Larimer, Benjamin M; Grassmann, Simon; Rapp, Moritz; Nottebrock, Alessia; Kruger, Stephan; Tokarew, Nicholas; Metzger, Philipp; Hoerth, Christine; Benmebarek, Mohamed-Reda; Dhoqina, Dario; Grünmeier, Ruth; Seifert, Matthias; Oener, Arman; Umut, Öykü; Joaquina, Sandy; Vimeux, Lene; Tran, Thi; Hank, Thomas; Baba, Taisuke; Huynh, Duc; Megens, Remco T A; Janssen, Klaus-Peter; Jastroch, Martin; Lamp, Daniel; Ruehland, Svenja; Di Pilato, Mauro; Pruessmann, Jasper N; Thomas, Moritz; Marr, Carsten; Ormanns, Steffen; Reischer, Anna; Hristov, Michael; Tartour, Eric; Donnadieu, Emmanuel; Rothenfusser, Simon; Duewell, Peter; König, Lars M.

Nat Biomed Eng ; 5(11): 1246-1260, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34083764

19.

Clonal expansion of innate and adaptive lymphocytes.

Adams, Nicholas M; Grassmann, Simon; Sun, Joseph C.

Nat Rev Immunol ; 20(11): 694-707, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32424244

20.

Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells.

Wiedemann, Gabriela M; Grassmann, Simon; Lau, Colleen M; Rapp, Moritz; Villarino, Alejandro V; Friedrich, Christin; Gasteiger, Georg; O'Shea, John J; Sun, Joseph C.

Cell Rep ; 33(11): 108498, 2020 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-33326784

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