Detalhe da pesquisa
1.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858142
2.
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
J Med Chem
; 60(24): 10071-10091, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29172502
3.
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.
J Med Chem
; 57(21): 8984-98, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25286150
4.
Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
J Med Chem
; 55(11): 5361-79, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22545772
5.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742641
6.
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem
; 55(20): 8827-37, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984809
7.
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.
Bioorg Med Chem Lett
; 15(1): 25-8, 2005 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15582404