Detalhe da pesquisa
1.
Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition.
EMBO J
; 43(5): 666-694, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279026
2.
Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer.
Trends Immunol
; 37(7): 462-476, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27216414
3.
Controlling lactation oestrus: The final frontier for breeding herd management.
Mol Reprod Dev
; 84(9): 883-896, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28628264
4.
The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
Bioorg Med Chem Lett
; 25(19): 4136-42, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26298499
5.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466188
6.
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Nat Cancer
; 5(1): 66-84, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151625
7.
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Blood Cancer J
; 13(1): 57, 2023 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37088806
8.
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(17): 5714-20, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22832322
9.
Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells.
Mol Cancer Ther
; 21(6): 879-889, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35364607
10.
AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer.
Clin Cancer Res
; 27(5): 1526-1537, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33203642
11.
Mixing Sows into Alternative Lactation Housing Affects Sow Aggression at Mixing, Future Reproduction and Piglet Injury, with Marked Differences between Multisuckle and Sow Separation Systems.
Animals (Basel)
; 9(9)2019 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31491961
12.
Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
J Med Chem
; 62(22): 10258-10271, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31736296
13.
Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping.
Animals (Basel)
; 9(1)2018 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30583570
14.
Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Blood Cancer J
; 13(1): 80, 2023 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37193700
15.
Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer.
Cancer Discov
; 8(12): 1598-1613, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254092
16.
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov
; 8(12): 1582-1597, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254093
17.
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J Med Chem
; 50(4): 611-26, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17253678
18.
Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase.
Mol Biol Cell
; 13(7): 2256-65, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12134066
19.
MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor.
Oncotarget
; 8(11): 17795-17809, 2017 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28147313
20.
In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Mol Cancer Ther
; 15(7): 1568-79, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27196782