[Several parameters of the state of the nervous, immune and endocrine systems in newborn rats exposed to irradiation during the preimplantation period of embryogenesis]. / Nekotorye pokazateli sostoianiia nervnoi, immunnoi i éndokrinnoi sistem u novorozhdennykh krys, podvergshikhsia oblucheniiu v doimplantasionnyi period émbriogeneza.

Protracted prenatal irradiation of animals at the preimplantation stage of embryogenesis is shown to produce disturbances in the development of regulation systems, with their consequences persisting up to sexually mature period of postnatal life. Unknown before, these effects of preimplantation irradiation give the experimental confirmation to the main statement of the previously proposed theoretical concept of the "systemic teratogenesis": the ultimate effect of prenatal irradiation is a distortion of the structure of postnatal neuroimmunoendocrine regulation in the direction of overdevelopment of its endocrine component with the following coadaptive underdevelopment of the nervous and immune components.

[The organization of an epidemiological surveillance of HIV infection in Krasnodar Territory]. / Organizatsiia épidemiologicheskogo nadzora za VICh-infektsiei v Krasnodarskom krae.

For the first time a case of AIDS was detected in the Krasnodar Territory of the USSR, and the presence of HIV infection in homosexuals, foreign students, and promiscuous persons was established. To study the spread of HIV infection, 5 diagnostic laboratories were created and 5 routes for the transportation of sera were organized. This permitted the screening of the population in 1988 with the complete coverage of groups to be placed under surveillance.

[Effect of corticosterone on mitochondrial respiration of slices of rat liver]. / Vliianie kortikosterona na mitokhondrial'noe dykhanie srezov pecheni krys.

The corticosterone effect on the cyanide-sensitive (mitochondrial) respiration of liver slices of intact and adrenalectomized rats has been studied. The 10(-5) M hormone has been shown to inhibit the mitochondrial respiration of intact rat liver slices. A similar effect is observed in adrenalectomized rats after a short-term stimulation. A stimulating effect of the 10(-8) M steroid on the mitochondrial liver slices respiration is observed in adrenalectomized rats only. Both stimulating and inhibiting effects are recorded 5 min after incubation of the slices with the hormone. It has been concluded that corticosterone can produce a direct effect on the liver cell mitochondrial respiration. It has been assumed that mitochodrial respiration stimulation by a physiological level of the steroid can be important for cell preparation for hormone nucleic effect realization.

[Nature of steroid hormone binding to mitochondria]. / Kharakter sviazyvaniia steroidnykh gormonov s mitokhonriiami.

Binding of 3H-corticosterone, 3H-estradiol and 3H-testosterone to the rat liver mitochondria was studied. One type of specific binding sites for corticosterone with association constant (3.25 +/- 0.51) X 10(10) M-1 and the number of binding sites (1.79 +/- +/- 0.21) X 10(-13) mol/mg of protein was found. Adrenalectomy did not change significantly corticosterone affinity to mitochondria but increased binding capacity by 70%. Binding of estradiol and testosterone was of non-specific, hydrophobic character.