Detalhe da pesquisa
1.
Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation.
Chem Res Toxicol
; 28(10): 1991-9, 2015 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26351880
2.
Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.
Bioorg Med Chem Lett
; 23(11): 3175-9, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23628336
3.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858142
4.
Selective non zinc binding inhibitors of MMP13.
Bioorg Med Chem Lett
; 21(14): 4215-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21669521
5.
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Bioorg Med Chem
; 18(21): 7486-96, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869876
6.
A simple in vitro assay for assessing the reactivity of nitrile containing compounds.
Bioorg Med Chem Lett
; 19(4): 1136-8, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168354
7.
Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.
Bioorg Med Chem Lett
; 19(16): 4832-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19574045
8.
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 19(6): 1658-61, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19231183
9.
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
ACS Med Chem Lett
; 9(8): 809-814, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128072
10.
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
J Med Chem
; 61(9): 3823-3841, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29683659
11.
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
ACS Med Chem Lett
; 7(1): 94-9, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819673
12.
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.
J Med Chem
; 57(21): 8984-98, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25286150
13.
Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
J Med Chem
; 55(11): 5361-79, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22545772
14.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742641
15.
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem
; 55(20): 8827-37, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984809
16.
Measurement of N-H Bond Strengths in Aromatic Amines by Photoacoustic Calorimetry(1).
J Org Chem
; 62(10): 3413-3414, 1997 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-11671733