Detalhe da pesquisa
1.
sp3 -Rich Heterocycle Synthesis on DNA: Application to DNA-Encoded Library Production.
Angew Chem Int Ed Engl
; 63(12): e202319836, 2024 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38330151
2.
Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties.
Bioconjug Chem
; 34(11): 2096-2111, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916986
3.
Rapid 18 F- and 19 F-Difluoromethylation through Desulfurative Fluorination of Transient N-, O-, and C-Linked Dithioles.
Chemistry
; 29(5): e202202862, 2023 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36318597
4.
Investigations into mRNA Lipid Nanoparticles Shelf-Life Stability under Nonfrozen Conditions.
Mol Pharm
; 20(12): 6492-6503, 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37975733
5.
Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial ß-Position to the Amino Group.
Chembiochem
; 21(1-2): 212-234, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31491045
6.
Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice.
Am J Physiol Endocrinol Metab
; 317(6): E1081-E1093, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31503512
7.
A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters Using Silver(I) Fluoride.
Chemistry
; 25(70): 15993-15997, 2019 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31538366
8.
Site-Selective, Late-Stage C-H 18 F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging.
Angew Chem Int Ed Engl
; 57(39): 12733-12736, 2018 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30086209
9.
18F-Fluorination of Unactivated C-H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents.
J Am Chem Soc
; 139(10): 3595-3598, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28248493
10.
Intramolecular Inverse Electron-Demand [4 + 2] Cycloadditions of Ynamides with Pyrimidines: Scope and Density Functional Theory Insights.
J Org Chem
; 82(3): 1726-1742, 2017 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28059511
11.
Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).
Org Biomol Chem
; 14(25): 5922-7, 2016 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27245438
12.
A Convenient Late-Stage Fluorination of Pyridylic C-H Bonds with N-Fluorobenzenesulfonimide.
Angew Chem Int Ed Engl
; 55(42): 13244-13248, 2016 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27653634
13.
A convenient photocatalytic fluorination of unactivated C-H bonds.
Angew Chem Int Ed Engl
; 53(18): 4690-3, 2014 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24668727
14.
Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of ß-secretase (BACE1) inhibitors.
Angew Chem Int Ed Engl
; 53(6): 1704-8, 2014 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24458566
15.
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning.
Nat Chem
; 16(2): 239-248, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996732
16.
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.
Bioorg Med Chem Lett
; 23(16): 4627-32, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23831134
17.
Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening.
Commun Chem
; 6(1): 256, 2023 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37985850
18.
Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.
Bioorg Med Chem Lett
; 21(1): 191-4, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21134747
19.
Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
JCI Insight
; 6(4)2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33434183
20.
Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists.
Bioorg Med Chem Lett
; 20(15): 4521-5, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20580234