Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.

LaMarche, Nelson M; Hegde, Samarth; Park, Matthew D; Maier, Barbara B; Troncoso, Leanna; Le Berichel, Jessica; Hamon, Pauline; Belabed, Meriem; Mattiuz, Raphaël; Hennequin, Clotilde; Chin, Theodore; Reid, Amanda M; Reyes-Torres, Iván; Nemeth, Erika; Zhang, Ruiyuan; Olson, Oakley C; Doroshow, Deborah B; Rohs, Nicholas C; Gomez, Jorge E; Veluswamy, Rajwanth; Hall, Nicole; Venturini, Nicholas; Ginhoux, Florent; Liu, Zhaoyuan; Buckup, Mark; Figueiredo, Igor; Roudko, Vladimir; Miyake, Kensuke; Karasuyama, Hajime; Gonzalez-Kozlova, Edgar; Gnjatic, Sacha; Passegué, Emmanuelle; Kim-Schulze, Seunghee; Brown, Brian D; Hirsch, Fred R; Kim, Brian S; Marron, Thomas U; Merad, Miriam.

Nature ; 625(7993): 166-174, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38057662

2.

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.

Shree, Tanaya; Olson, Oakley C; Elie, Benelita T; Kester, Jemila C; Garfall, Alfred L; Simpson, Kenishana; Bell-McGuinn, Katherine M; Zabor, Emily C; Brogi, Edi; Joyce, Johanna A.

Genes Dev ; 25(23): 2465-79, 2011 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-22156207

3.

Made to order: emergency myelopoiesis and demand-adapted innate immune cell production.

Swann, James W; Olson, Oakley C; Passegué, Emmanuelle.

Nat Rev Immunol ; 2024 Mar 11.

Artigo em Inglês | MEDLINE | ID: mdl-38467802

4.

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production.

Kang, Yoon-A; Paik, Hyojung; Zhang, Si Yi; Chen, Jonathan J; Olson, Oakley C; Mitchell, Carl A; Collins, Amelie; Swann, James W; Warr, Matthew R; Fan, Rong; Passegué, Emmanuelle.

J Exp Med ; 220(8)2023 08 07.

Artigo em Inglês | MEDLINE | ID: mdl-37115584

5.

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.

Mitchell, Carl A; Verovskaya, Evgenia V; Calero-Nieto, Fernando J; Olson, Oakley C; Swann, James W; Wang, Xiaonan; Hérault, Aurélie; Dellorusso, Paul V; Zhang, Si Yi; Svendsen, Arthur Flohr; Pietras, Eric M; Bakker, Sietske T; Ho, Theodore T; Göttgens, Berthold; Passegué, Emmanuelle.

Nat Cell Biol ; 25(1): 30-41, 2023 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-36650381

6.

Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration.

Olson, Oakley C; Kang, Yoon-A; Passegué, Emmanuelle.

Cold Spring Harb Perspect Med ; 10(12)2020 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-31988205

7.

Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis.

Yamashita, Masayuki; Dellorusso, Paul V; Olson, Oakley C; Passegué, Emmanuelle.

Nat Rev Cancer ; 20(7): 365-382, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32415283

8.

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.

Olson, Oakley C; Kim, Hyunjung; Quail, Daniela F; Foley, Emily A; Joyce, Johanna A.

Cell Rep ; 19(1): 101-113, 2017 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-28380350

9.

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.

Quail, Daniela F; Olson, Oakley C; Bhardwaj, Priya; Walsh, Logan A; Akkari, Leila; Quick, Marsha L; Chen, I-Chun; Wendel, Nils; Ben-Chetrit, Nir; Walker, Jeanne; Holt, Peter R; Dannenberg, Andrew J; Joyce, Johanna A.

Nat Cell Biol ; 19(8): 974-987, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28737771

10.

Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.

Bakst, Richard L; Xiong, Huizhong; Chen, Chun-Hao; Deborde, Sylvie; Lyubchik, Anna; Zhou, Yi; He, Shizhi; McNamara, William; Lee, Sei-Young; Olson, Oakley C; Leiner, Ingrid M; Marcadis, Andrea R; Keith, James W; Al-Ahmadie, Hikmat A; Katabi, Nora; Gil, Ziv; Vakiani, Efsevia; Joyce, Johanna A; Pamer, Eric; Wong, Richard J.

Cancer Res ; 77(22): 6400-6414, 2017 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-28951461

11.

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova, Anna; Gocheva, Vasilena; Auf dem Keller, Ulrich; Eckhard, Ulrich; Olson, Oakley C; Akkari, Leila; Butler, Georgina S; Fortelny, Nikolaus; Lange, Philipp F; Mark, Jennifer C; Joyce, Johanna A; Overall, Christopher M.

Cell Rep ; 16(6): 1762-1773, 2016 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-27477282

12.

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.

Olson, Oakley C; Joyce, Johanna A.

Nat Rev Cancer ; 15(12): 712-29, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26597527

13.

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy.

Hughes, Russell; Qian, Bin-Zhi; Rowan, Charlotte; Muthana, Munitta; Keklikoglou, Ioanna; Olson, Oakley C; Tazzyman, Simon; Danson, Sarah; Addison, Christina; Clemons, Mark; Gonzalez-Angulo, Ana Maria; Joyce, Johanna A; De Palma, Michele; Pollard, Jeffrey W; Lewis, Claire E.

Cancer Res ; 75(17): 3479-91, 2015 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-26269531

14.

Microenvironment-mediated resistance to anticancer therapies.

Olson, Oakley C; Joyce, Johanna A.

Cell Res ; 23(2): 179-81, 2013 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-22945358

15.

A splicing twist on metastasis.

Olson, Oakley C; Joyce, Johanna A.

Sci Transl Med ; 5(169): 169fs2, 2013 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-23345607

16.

CSF-1R inhibition alters macrophage polarization and blocks glioma progression.

Pyonteck, Stephanie M; Akkari, Leila; Schuhmacher, Alberto J; Bowman, Robert L; Sevenich, Lisa; Quail, Daniela F; Olson, Oakley C; Quick, Marsha L; Huse, Jason T; Teijeiro, Virginia; Setty, Manu; Leslie, Christina S; Oei, Yoko; Pedraza, Alicia; Zhang, Jianan; Brennan, Cameron W; Sutton, James C; Holland, Eric C; Daniel, Dylan; Joyce, Johanna A.

Nat Med ; 19(10): 1264-72, 2013 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24056773

17.

Obesity and the tumor microenvironment.

Olson, Oakley C; Quail, Daniela F; Joyce, Johanna A.

Science ; 358(6367): 1130-1131, 2017 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-29191893

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An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.

Made to order: emergency myelopoiesis and demand-adapted innate immune cell production.

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production.

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.

Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration.

Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis.

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.

Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy.

Microenvironment-mediated resistance to anticancer therapies.

A splicing twist on metastasis.

CSF-1R inhibition alters macrophage polarization and blocks glioma progression.

Obesity and the tumor microenvironment.