Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

SLC25A51 is a mammalian mitochondrial NAD⁺ transporter.

Luongo, Timothy S; Eller, Jared M; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R; Migaud, Marie E; Rabinowitz, Joshua D; Johnson, F Brad; Johnsson, Kai; Ziegler, Mathias; Cambronne, Xiaolu A; Baur, Joseph A.

Nature ; 588(7836): 174-179, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32906142

2.

Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.

Wagenlehner, Florian; Perry, Caroline R; Hooton, Thomas M; Scangarella-Oman, Nicole E; Millns, Helen; Powell, Marcy; Jarvis, Emily; Dennison, Jeremy; Sheets, Amanda; Butler, Deborah; Breton, John; Janmohamed, Salim.

Lancet ; 403(10428): 741-755, 2024 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-38342126

3.

Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea.

Scangarella-Oman, Nicole E; Hossain, Mohammad; Perry, Caroline R; Tiffany, Courtney; Powell, Marcy; Swift, Brandon; Dumont, Etienne F.

Sex Transm Infect ; 99(1): 64-69, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36411033

4.

Pharmacokinetics of Oral Formulations of Gepotidacin (GSK2140944), a Triazaacenaphthylene Bacterial Type II Topoisomerase Inhibitor, in Healthy Adult and Adolescent Participants.

Barth, Aline; Hossain, Mohammad; Brimhall, Darin B; Perry, Caroline R; Tiffany, Courtney A; Xu, Sherry; Dumont, Etienne F.

Antimicrob Agents Chemother ; 66(1): e0126321, 2022 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-34633853

5.

Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections.

Scangarella-Oman, Nicole E; Hossain, Mohammad; Hoover, Jennifer L; Perry, Caroline R; Tiffany, Courtney; Barth, Aline; Dumont, Etienne F.

Antimicrob Agents Chemother ; 66(3): e0149221, 2022 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-34978887

6.

Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague.

Nguyen, Dung; Shaik, Jafar Sadik; Tai, Guoying; Tiffany, Courtney; Perry, Caroline; Dumont, Etienne; Gardiner, David; Barth, Aline; Singh, Rajendra; Hossain, Mohammad.

Br J Clin Pharmacol ; 88(2): 416-428, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34289143

7.

Cancer aided by greasy traitors.

Perry, Caroline; Beier, Ulf H.

Nature ; 591(7849): 204-206, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33627861

8.

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy.

Kopinski, Piotr K; Janssen, Kevin A; Schaefer, Patrick M; Trefely, Sophie; Perry, Caroline E; Potluri, Prasanth; Tintos-Hernandez, Jesus A; Singh, Larry N; Karch, Kelly R; Campbell, Sydney L; Doan, Mary T; Jiang, Helen; Nissim, Itzhak; Nakamaru-Ogiso, Eiko; Wellen, Kathryn E; Snyder, Nathaniel W; Garcia, Benjamin A; Wallace, Douglas C.

Proc Natl Acad Sci U S A ; 116(32): 16028-16035, 2019 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-31253706

9.

Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944).

Nuzzo, Andrea; Van Horn, Stephanie; Traini, Christopher; Perry, Caroline R; Dumont, Etienne F; Scangarella-Oman, Nicole E; Gardiner, David F; Brown, James R.

BMC Microbiol ; 21(1): 181, 2021 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-34130619

10.

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

Casciano, Jessica C; Perry, Caroline; Cohen-Nowak, Adam J; Miller, Katelyn D; Vande Voorde, Johan; Zhang, Qifeng; Chalmers, Susan; Sandison, Mairi E; Liu, Qin; Hedley, Ann; McBryan, Tony; Tang, Hsin-Yao; Gorman, Nicole; Beer, Thomas; Speicher, David W; Adams, Peter D; Liu, Xuefeng; Schlegel, Richard; McCarron, John G; Wakelam, Michael J O; Gottlieb, Eyal; Kossenkov, Andrew V; Schug, Zachary T.

Br J Cancer ; 122(6): 868-884, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31942031

11.

Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis).

Overcash, J Scott; Tiffany, Courtney A; Scangarella-Oman, Nicole E; Perry, Caroline R; Tao, Yu; Hossain, Mohammad; Barth, Aline; Dumont, Etienne F.

Antimicrob Agents Chemother ; 64(7)2020 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-32284384

12.

In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.

Scangarella-Oman, Nicole E; Ingraham, Karen A; Tiffany, Courtney A; Tomsho, Lynn; Van Horn, Stephanie F; Mayhew, David N; Perry, Caroline R; Ashton, Theresa C; Dumont, Etienne F; Huang, Jianzhong; Brown, James R; Miller, Linda A.

Antimicrob Agents Chemother ; 64(3)2020 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-31818823

13.

Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection.

Beier, Ulf H; Hartung, Erum A; Concors, Seth; Hernandez, Paul T; Wang, Zhonglin; Perry, Caroline; Baur, Joseph A; Denburg, Michelle R; Hancock, Wayne W; Gade, Terence P; Levine, Matthew H.

Metabolomics ; 16(5): 65, 2020 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-32367163

14.

Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.

Vegvari, Carolin; Grad, Yonatan H; White, Peter J; Didelot, Xavier; Whittles, Lilith K; Scangarella-Oman, Nicole E; Mitrani-Gold, Fanny S; Dumont, Etienne; Perry, Caroline R; Gilchrist, Kim; Hossain, Mohammad; Mortimer, Tatum D; Anderson, Roy M; Gardiner, David.

Euro Surveill ; 25(43)2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-33124551

15.

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation.

Taylor, Stephanie N; Morris, David H; Avery, Ann K; Workowski, Kimberly A; Batteiger, Byron E; Tiffany, Courtney A; Perry, Caroline R; Raychaudhuri, Aparna; Scangarella-Oman, Nicole E; Hossain, Mohammad; Dumont, Etienne F.

Clin Infect Dis ; 67(4): 504-512, 2018 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-29617982

16.

Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae.

Scangarella-Oman, Nicole E; Hossain, Mohammad; Dixon, Paula B; Ingraham, Karen; Min, Sharon; Tiffany, Courtney A; Perry, Caroline R; Raychaudhuri, Aparna; Dumont, Etienne F; Huang, Jianzhong; Hook, Edward W; Miller, Linda A.

Antimicrob Agents Chemother ; 62(12)2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30249694

17.

Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections.

O'Riordan, William; Tiffany, Courtney; Scangarella-Oman, Nicole; Perry, Caroline; Hossain, Mohammad; Ashton, Teri; Dumont, Etienne.

Antimicrob Agents Chemother ; 61(6)2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28373199

18.

Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise.

Nauck, Michael A; Stewart, Murray W; Perkins, Christopher; Jones-Leone, Angela; Yang, Fred; Perry, Caroline; Reinhardt, Rickey R; Rendell, Marc.

Diabetologia ; 59(2): 266-74, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26577795

19.

Correction to: Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK2140944).

Nuzzo, Andrea; Van Horn, Stephanie; Traini, Christopher; Perry, Caroline R; Dumont, Etienne F; Scangarella-Oman, Nicole E; Gardiner, David F; Brown, James R.

BMC Microbiol ; 21(1): 293, 2021 Oct 26.

Artigo em Inglês | MEDLINE | ID: mdl-34702186

20.

HARMONY 4: randomised clinical trial comparing once-weekly albiglutide and insulin glargine in patients with type 2 diabetes inadequately controlled with metformin with or without sulfonylurea.

Weissman, Peter N; Carr, Molly C; Ye, June; Cirkel, Deborah T; Stewart, Murray; Perry, Caroline; Pratley, Richard.

Diabetologia ; 57(12): 2475-84, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-25208756

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