Detalhe da pesquisa
1.
Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation.
Proc Natl Acad Sci U S A
; 117(2): 1000-1008, 2020 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882446
2.
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Mol Cell
; 53(5): 738-51, 2014 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24560924
3.
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
J Med Chem
; 67(4): 2619-2630, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38294341
4.
Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.
J Adv Res
; 45: 87-100, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35595215
5.
An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Nat Commun
; 14(1): 6548, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37848415
6.
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
J Biol Chem
; 286(19): 17292-302, 2011 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454698
7.
Current concepts in RET-related genetics, signaling and therapeutics.
Trends Genet
; 22(11): 627-36, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16979782
8.
Structure and function of RET in multiple endocrine neoplasia type 2.
Endocr Relat Cancer
; 25(2): T79-T90, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29175871
9.
Novel targeted therapeutics for MEN2.
Endocr Relat Cancer
; 25(2): T53-T68, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348306
10.
RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.
Cancer Res
; 65(5): 1729-37, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15753368
11.
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking.
Sci Adv
; 2(9): e1600823, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27652341
12.
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Cell Rep
; 17(12): 3319-3332, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009299
13.
Localizing a putative mutation as the major contributor to the development of sporadic Hirschsprung disease to the RET genomic sequence between the promoter region and exon 2.
Eur J Hum Genet
; 12(8): 604-12, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15138456
14.
Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase.
Mol Cell Endocrinol
; 377(1-2): 1-6, 2013 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23811235
15.
GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
Cancer Res
; 73(12): 3783-95, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650283
16.
RET in breast cancer: functional and therapeutic implications.
Trends Mol Med
; 17(3): 149-57, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21251878
17.
Re: "Inhibition of medullary thyroid carcinoma (MTC) cell proliferation and RET phosphorylation by tyrosine kinase inhibitors".
Surgery
; 135(2): 240-1; author reply 241, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14760839
18.
A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer.
Cancer Res
; 67(24): 11732-41, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18089803
19.
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.
J Biol Chem
; 282(40): 29230-40, 2007 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17664273
20.
Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
J Biol Chem
; 282(9): 6415-24, 2007 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17209045