Bright solitons in a spin-orbit-coupled dipolar Bose-Einstein condensate trapped within a double-lattice.

By effectively controlling the dipole-dipole interaction, we investigate the characteristics of the ground state of bright solitons in a spin-orbit coupled dipolar Bose-Einstein condensate. The dipolar atoms are trapped within a double-lattice which consists of a linear and a nonlinear lattice. We derive the motion equations of the different spin components, taking the controlling mechanisms of the dipole-dipole interaction into account. An analytical expression of dipole-dipole interaction is derived. By adjusting the dipole polarization angle, the dipole interaction can be adjusted from attraction to repulsion. On this basis, we study the generation and manipulation of the bright solitons using both the analytical variational method and numerical imaginary time evolution. The stability of the bright solitons is also analyzed and we map out the stability phase diagram. By adjusting the long-range dipole-dipole interaction, one can achieve manipulation of bright solitons in all aspects, including the existence, width, nodes, and stability. Considering the complexity of our system, our results will have enormous potential applications in quantum simulation of complex systems.

Blood and Bronchoalveolar Lavage Fluid Metagenomic Next-Generation Sequencing in Pneumonia.

BACKGROUND: Metagenomic next-generation sequencing (mNGS) has made a revolution in the mode of pathogen identification. We decided to explore the diagnostic value of blood and bronchoalveolar lavage fluid (BALF) as mNGS samples in pneumonia. METHODS: We retrospectively reviewed 467 mNGS results and assessed the diagnostic performance of paired blood and BALF mNGS in 39 patients with pneumonia. RESULTS: For bacteria and fungi, 16 patients had culture-confirmed pathogen diagnosis, while 13 patients were culture-negative. BALF mNGS was more sensitive than blood mNGS (81.3% vs. 25.0%, p=0.003), and the specificity in BALF and blood mNGS was not statistically significant different (76.9% vs. 84.6%, p=0.317). For 10 patients without culture test, treatments were changed in 2 patients. For viruses, Epstein-Barr virus was positive in blood mNGS in 9 patients. Human adenovirus was detected in both BALF and blood mNGS in 3 patients. CONCLUSION: Our study suggests that BALF mNGS is more sensitive than blood mNGS in detecting bacteria and fungi, but blood also has advantages to identify the pathogens of pneumonia, especially for some viruses.

Hybrid Matter-Wave-Microwave Solitons Produced by the Local-Field Effect.

It was recently found that the electric local-field effect (LFE) can lead to a strong coupling of atomic Bose-Einstein condensates (BECs) to off-resonant optical fields. We demonstrate that the magnetic LFE gives rise to a previously unexplored mechanism for coupling a (pseudo-) spinor BEC or fermion gas to microwaves (MWs). We present a theory for the magnetic LFE and find that it gives rise to a short-range attractive interaction between two components of the (pseudo) spinor, and a long-range interaction between them. The latter interaction, resulting from deformation of the magnetic field, is locally repulsive but globally attractive, in sharp contrast with its counterpart for the optical LFE, produced by phase modulation of the electric field. Our analytical results, confirmed by the numerical computations, show that the long-range interaction gives rise to modulational instability of the spatially uniform state, and it creates stable ground states in the form of hybrid matter-wave-microwave solitons (which seem like one-dimensional magnetic monopoles), with a size much smaller than the MW wavelength, even in the presence of arbitrarily strong contact intercomponent repulsion. The setting is somewhat similar to exciton-polaritonic condensates in semiconductor microcavities. The release of matter waves from the soliton may be used for the realization of an atom laser. The analysis also applies to molecular BECs with rotational states coupled by the electric MW field.

Supersolid gap soliton in a Bose-Einstein condensate and optical ring cavity coupling system.

The system of a transversely pumped Bose-Einstein condensate (BEC) coupled to a lossy ring cavity can favor a supersolid steady state. Here we find the existence of supersolid gap soliton in such a driven-dissipative system. By numerically solving the mean-field atom-cavity field coupling equations, gap solitons of a few different families have been identified. Their dynamical properties, including stability, propagation, and soliton collision, are also studied. Due to the feedback atom-intracavity field interaction, these supersolid gap solitons show numerous new features compared with the usual BEC gap solitons in static optical lattices.

Collision of two self-trapped atomic matter wave packets in an optical ring cavity.

The interaction between atomic Bose-Einstein condensate (BEC) and light field in an optical ring cavity gives rise to many interesting phenomena such as supersolid and movable self-trapped matter wave packets. Here we examined the collision of two self-trapped atomic matter wave packets in an optical ring cavity, and abundant colliding phenomena have been found in the system. Depending on the magnitude of colliding velocity, the collision dynamics exhibit very different features compared with the cavity-free case. When the initial colliding velocities of the two wave packets are small, they correlatedly oscillate around their initial equilibrium positions with a small amplitude. Increasing the collision velocity leads to severe scattering of the BEC atoms; after the collision, the two self-trapped wave packets usually break into small pieces. Interestingly, we found that such a medium velocity collision is of great phase sensitivity, which may make the system useful in precision matter wave interferometry. When the colliding velocity is further increased, in the bad cavity limit, the two wave packets collide phenomenally similar to two classical particles-they first approach each other, then separate with their shape virtually maintained. However, beyond the bad cavity limit, they experience severe spatial spreading.

Identification and functional characterization of a novel surfactant protein A2 mutation (p.N207Y) in a Chinese family with idiopathic pulmonary fibrosis.

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a serious disorder with a high mortality rate worldwide. It is characterized by irreversible scarring of the lung parenchyma resulting from excessive collagen production by proliferating fibroblasts/myofibroblasts. Previous studies have revealed that mutations in surfactant protein-related genes and telomerase complex genes are crucial underlying genetic factors. METHODS: In this study, we enrolled a family with IPF from the central southern region of China. Whole-exome sequencing was employed to explore candidate genes in this family. Real-time PCR and western blotting were used to study the functions of the identified mutations in vitro. RESULTS: A novel mutation (NM_001098668.4: c.619A>T; NP_001092138.1: p.N207Y) in surfactant protein A2 (SFTPA2,), having not been previously reported to be a mutation, was identified and co-separated with all affected individuals in the IPF family. Functional research further revealed that the novel mutation affects the secretion of SFTPA2 protein and induces endoplasmic reticulum stress as well as apoptosis in A549 cells. CONCLUSION: We are confident that this novel mutation (NM_001098668.4: c.619A>T; NP_001092138.1: p.N207Y) in SFTPA2 is the genetic mutation of the IPF family. Our study not only confirms the importance of SFTPA2 in IPF but also expands the spectrum of SFTPA2 mutations and contributes to the genetic diagnosis and counseling of IPF patients.

Memristive synapses with high reproducibility for flexible neuromorphic networks based on biological nanocomposites.

Memristive synapses from biomaterials are promising for building flexible and implantable artificial neuromorphic systems due to their remarkable mechanical and biological properties. However, these biological devices have relatively poor memristive switching characteristics, and thus fail to meet the requirement of neuromorphic networks for high learning accuracy. Here, memristive synapses based on carrageenan nanocomposites that possess desirable characteristics are demonstrated. These devices show highly reproducible analog resistive switching behaviors with 250 conductance states, low write noise, good write linearity, high retention of more than 104 s and endurance for at least 106 pulses. The enhanced switching properties are attributed to controllable and confined conductive filament growth, owing to the synergistic effect of self-assembled silver nanocluster doping and nanocone-shaped electrode contact. Moreover, the devices exhibit excellent reliability after 1000 bending cycles. Simulations including the non-ideal factors prove that the synaptic device array can operate with an online learning accuracy of 94.3%. These findings enable broader applications of biomaterials in flexible memristive devices and neuromorphic systems.

Solution-processed inorganic δ-phase CsPbI3 electronic synapses with short- and long-term plasticity in a crossbar array structure.

Electronic synapses based on memristive devices can potentially open a niche area for neuromorphic computing by replicating the function of biological synapses with high fidelity. Recently, two-terminal memristors based on halide perovskites have demonstrated outstanding memristive properties and a variety of synaptic characteristics, combining with their additional advantages such as a solution-processed fabrication method and low crystalline temperature. However, the concerns over the chemical and phase stability of halide perovskites greatly hinder their practical applications. In this study, by using a simple single-step spin-coating method, we report artificial synapses with superior ambient stability (>90 days under ambient conditions) based on fully inorganic nonperovskite δ-phase CsPbI3 in a cross-bar array architecture. The threshold switching memristive device exhibits a moderate ON/OFF ratio, a relatively low operation voltage (0.3 V) and high endurance (>5 × 105). More importantly, the electronic device can emulate synaptic characteristics such as short-term plasticity, paired-pulse facilitation, and the transition from short-term memory to long-term memory with a high output signal-to-noise ratio (>102). This work represents the first record for artificial synapses based on nonperovskite CsPbI3 and will be a step toward achieving low-cost and high-density practical synapse arrays.

[Detection Rate of Central Nervous System Leukemia Can Be Improved by Cell Preservation Solution].

OBJECTIVE: To investigate whether cell preservation solution can prolong the survival time of leukemia cells and increase the survival rate, so as to improve the detection rate of central nervous system leukemia. METHODS: Kasumi cells were added into cerebrospinal fluid (CSF) supernatant with or without cell preservation solution to compare cell viability and biological characteristics at different time point. Wright Giemsa staining was used to compare cell morphology; cell counting, CCK-8 method, and trypan blue staining were used to compare the cell number, and flow cytometry was used to compare the cell viability. The expression of AML-ETO tumor fusion gene was detected by fluorescence quantitative RT-PCR. RESULTS: At different time points (8 h and 24 h), the survival, molecular biological characteristics and RT-PCR result of the cells in CSF with cell preservation solution were significantly better than those in normal cerebrospinal fluid. CONCLUSION: Cell preservation solution can effectively improve the survival time and survival rate of leukemic cells, thereby increase the detection rate of CNS leukemia.