Detalhe da pesquisa
1.
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
EMBO J
; 39(21): e105111, 2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945574
2.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Proc Natl Acad Sci U S A
; 116(36): 17990-18000, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439820
3.
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Br J Cancer
; 124(3): 616-627, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33173151
4.
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
Proc Natl Acad Sci U S A
; 115(18): 4737-4742, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669917
5.
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Blood
; 129(21): 2882-2895, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283481
6.
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
Int J Cancer
; 142(10): 2139-2152, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243224
7.
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Genome Res
; 25(2): 201-12, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452314
8.
Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.
PLoS Genet
; 10(8): e1004505, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25121932
9.
The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.
Int J Mol Sci
; 18(1)2017 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28117679
10.
ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia.
Sci Adv
; 10(10): eadj8803, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457494
11.
Targeting the ribosome to treat multiple myeloma.
Mol Ther Oncol
; 32(1): 200771, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38596309
12.
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation.
Nucleic Acids Res
; 39(8): 3267-81, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21177653
13.
Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia.
EJHaem
; 4(4): 1105-1109, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-38024622
14.
Clinical Application of Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Prostate Cancer.
Cancers (Basel)
; 14(23)2022 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36497408
15.
Cystathionine-ß-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation.
Elife
; 112022 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35758651
16.
Signaling to the ribosome in cancer--It is more than just mTORC1.
IUBMB Life
; 63(2): 79-85, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21360636
17.
Harnessing the Nucleolar DNA Damage Response in Cancer Therapy.
Genes (Basel)
; 12(8)2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34440328
18.
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy.
Signal Transduct Target Ther
; 6(1): 323, 2021 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34462428
19.
The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function.
Nat Cell Biol
; 23(11): 1136-1147, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34750583
20.
CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.
Mol Cancer Ther
; 20(11): 2140-2150, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413130