[Several parameters of the state of the nervous, immune and endocrine systems in newborn rats exposed to irradiation during the preimplantation period of embryogenesis]. / Nekotorye pokazateli sostoianiia nervnoi, immunnoi i éndokrinnoi sistem u novorozhdennykh krys, podvergshikhsia oblucheniiu v doimplantasionnyi period émbriogeneza.

Protracted prenatal irradiation of animals at the preimplantation stage of embryogenesis is shown to produce disturbances in the development of regulation systems, with their consequences persisting up to sexually mature period of postnatal life. Unknown before, these effects of preimplantation irradiation give the experimental confirmation to the main statement of the previously proposed theoretical concept of the "systemic teratogenesis": the ultimate effect of prenatal irradiation is a distortion of the structure of postnatal neuroimmunoendocrine regulation in the direction of overdevelopment of its endocrine component with the following coadaptive underdevelopment of the nervous and immune components.

[Comparative evaluation of the hypolipidemic action of sunflower oil and "Zdorov'e" margarine incorporated into the anti-atherosclerotic diet of ischemic heart disease patients]. / Sravnitel'naia otsenka gipolipidemicheskogo deistviia podsolnechnogo masla i margarina "Zdorov'e", vkliuchennykh v protivoateroskleroticheskuiu dietu bol'nykh ishemicheskoi bolezn'iu serdtsa.

Patients with ischemic heart disease attended by type II hyperlipidemia received diets containing sunflower oil (group I) or margarine "Zdorovie" (group II) as a source of poly-unsaturated fatty acids. Pronounced reduction of the blood cholesterol level was recorded in both groups of patients studied. Margarine "Zdorovie" is recommended for subjects intolerant to vegetable oils.

[Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]. / Deistvie likopina na lipoproteidy krovi u zhenshchin s sakharnym diabetom 2 tipa v postmenopauze.

Blind randomized placebo-control research included 39 women. The following criteria were: menopause period for more then 1 year long; diabetes mellitus; arterial hypertension; hypercholesterolemia. The patients were divided into two groups. Women from the first group (N = 24) were given 30 mg lycopene (composed with "Tomatol") per day during 24 weeks. The second group (N = 15) were given placebo. It was showed that during 12-week "Tomatol" intake we state that lycopene concentration in serum increased twice (337.0 +/- 133.0 nM), total cholesterol (CH) and CH LDL decreased by 12% and 16% respectively. The lipoproteins spectrum normalization correlated to serum antioxidative activity (r = 0.30, p < 0.05), and malonic dialdehyde concentration decrease by 44.8% correlated to lycopene increase (r = -0.51, p < 0.05). Our results give us a possibility to use "Tomatol" as an additional medicine for the prevention of atherosclerosis.

Acyclic analogs of nucleosides. Synthesis of hydroxyalkyl derivatives of 2-trifluoromethyl- and 2-trifluoromethylthiobenzimidazole.

1-(2,3-Dihydroxypropyl)-, 1-(4-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, 1-(1,5-dihydroxy-3-oxa-2-pentyl)-, 1-(5-hydroxy-3-oxa-2-pentyl)-, and 1-(4,5-dihydroxy-2-oxapentyl)-2-trifluoromethyl- and -2-trifluoromethylthiobenzimidazoles were obtained by condensation of trimethylsilyl derivatives of 2-substituted benzimidazoles with alkylating agents in the presence of SnCl4, or by direct alkylation of the sodium salts of the heterocycles.