Detalhe da pesquisa
1.
BET bromodomain inhibitors regulate keratinocyte plasticity.
Nat Chem Biol
; 17(3): 280-290, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33462494
2.
New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides.
Chem Res Toxicol
; 33(7): 1551-1560, 2020 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32525307
3.
Fixing clearance as early as lead optimization using high throughput in vitro incubations in combination with exact mass detection and automatic structure elucidation of metabolites.
Drug Discov Today Technol
; 10(1): e191-8, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24175349
4.
An integrated approach for identification and target validation of antifungal compounds active against Erg11p.
Antimicrob Agents Chemother
; 56(8): 4233-40, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22615293
5.
CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs.
Drug Metab Dispos
; 39(6): 1039-46, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383203
6.
CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.
Drug Metab Dispos
; 39(2): 191-8, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21045201
7.
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem
; 63(10): 5102-5118, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083858
8.
Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.
ACS Med Chem Lett
; 10(10): 1467-1472, 2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620235
9.
Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.
J Biomol Screen
; 13(5): 343-53, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18474896
10.
High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.
Expert Opin Drug Metab Toxicol
; 2(6): 823-33, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125403
11.
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
J Med Chem
; 47(20): 4950-7, 2004 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15369399
12.
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
J Med Chem
; 54(20): 7066-83, 2011 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21936542
13.
Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.
J Med Chem
; 52(2): 329-35, 2009 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19108654
14.
Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro.
Drug Metab Dispos
; 34(5): 765-74, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16467136
15.
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Bioorg Med Chem Lett
; 12(16): 2109-12, 2002 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12127515