Intralabyrinthine schwannoma: Surgical management and cochlear lumen preservation.

The present video reports the surgical removal of an intralabyrinthine schwannoma. The video contains patient's medical history, preoperative radiological evaluations and detailed description of surgical steps of the procedure, consisting in labyrinthectomy, cochleostomy and insertion of a dummy electrode in the preserved cochlear lumen within the context of a subtotal petrosectomy.

The Effect of Changing the Angle of the Passenger Car Seat Backrest on the Head Trajectories of the 50th Percentile Male Dummy.

The aim of the study is to compare the head displacement of the KPSIT C50 dummy during a frontal collision at a speed of 20 km/h, along with the change in the angle of the car seat backrest. Passenger car manufacturers recommend setting the backrest angle of the car seat between 100 and 125 degrees. It should be noted that the driver's position is of great importance in the event of a collision injury. In the event of a rear-end collision, the position of the headrest of the car seat is an element that affects the degree of the driver's injuries. In extreme cases, incorrect positioning of the headrest, even at low speed, can lead to serious injuries to the cervical spine and even death. The article is part of a large-scale study on low-speed crash testing. The research problem concerned the influence of the seat backrest angle on the head displacement during a low-speed collision. The article compares the displacement of the head of the KPSIT C50 dummy during a series of crash tests, where the angle of the car seat backrest was changed. On the basis of the research, it was found that the optimal angle of the car seat backrest is 110 degrees. In addition, a preliminary analysis of the displacements of the dummy's head showed a high risk of whiplash injury in people sitting in a fully reclined seat.

Corrosion Monitoring by Plastic Optic Fiber Sensor Using Bi-Directional Light Transmission.

In this paper, a new sensor is proposed to efficiently gather crucial information on corrosion phenomena and their progression within steel components. Fabricated with plastic optical fibers (POF), the sensor can detect corrosion-induced physical changes in the appearance of monitoring points within the steel material. Additionally, the new sensor incorporates an innovative structure that efficiently utilizes bi-directional optical transmission in the POF, simplifying the installation procedure and reducing the total cost of the POF cables by as much as 50% when monitoring multiple points. Furthermore, an extremely compact dummy sensor with the length of 5 mm and a diameter of 2.2 mm for corrosion-depth detection was introduced, and its functionality was validated through experiments. This paper outlines the concept and fundamental structure of the proposed sensor; analyzes the results of various experiments; and discusses its effectiveness, prospects, and economic advantages.

Synthesis of Boronate Affinity-Based Oriented Dummy Template-Imprinted Magnetic Nanomaterials for Rapid and Efficient Solid-Phase Extraction of Ellagic Acid from Food.

Ellagic acid (EA) is a natural polyphenol and possesses excellent in vivo bioactivity and antioxidant behaviors, which play an important role in the treatment of oxidative stress-related diseases, such as cancer. Additionally, EA is also known as a skin-whitening ingredient. The content of EA would determine its efficacy. Therefore, the accurate analysis of EA content can provide more information for the scientific consumption of EA-rich foods and cosmetics. Nevertheless, the analysis of EA in these samples is challenging due to the low concentration level and the presence of interfering components with high abundance. Molecularly imprinted polymers are highly efficient pretreatment materials in achieving specific recognition of target molecules. However, the traditional template molecule (EA) could not be absolutely removed. Hence, template leakage continues to occur during the sample preparation process, leading to a lack of accuracy in the quantification of EA in actual samples, particularly for trace analytes. In addition, another drawback of EA as an imprinting template is that EA possesses poor solubility and a high price. Gallic acid (GA), called dummy templates, was employed for the synthesis of MIPs as a solution to these challenges. The approach used in this study was boronate affinity-based oriented surface imprinting. The prepared dummy-imprinted nanoparticles exhibited several significant advantages, such as good specificity, high binding affinity ((4.89 ± 0.46) × 10-5 M), high binding capacity (6.56 ± 0.35 mg/g), fast kinetics (6 min), and low binding pH (pH 5.0) toward EA. The reproducibility of the dummy-imprinted nanoparticles was satisfactory. The dummy-imprinted nanoparticles could still be reused even after six adsorption-desorption cycles. In addition, the recoveries of the proposed method for EA at three spiked levels of analysis in strawberry and pineapple were 91.0-106.8% and 93.8-104.0%, respectively, which indicated the successful application to real samples.

Investigation on vehicle occupant dummy applicability for under-foot impact loading conditions.

PURPOSE: Under-foot impact loadings can cause serious lower limb injuries in many activities, such as automobile collisions and underbody explosions to military vehicles. The present study aims to compare the biomechanical responses of the mainstream vehicle occupant dummies with the human body lower limb model and analyze their robustness and applicability for assessing lower limb injury risk in under-foot impact loading environments. METHODS: The Hybrid III model, the test device for human occupant restraint (THOR) model, and a hybrid human body model with the human active lower limb model were adopted for under-foot impact analysis regarding different impact velocities and initial lower limb postures. RESULTS: The results show that the 2 dummy models have larger peak tibial axial force and higher sensitivity to the impact velocities and initial postures than the human lower limb model. In particular, the Hybrid III dummy model presented extremely larger peak tibial axial forces than the human lower limb model. In the case of minimal difference in tibial axial force, Hybrid III's tibial axial force (7.5 KN) is still 312.5% that of human active lower limb's (2.4 KN). Even with closer peak tibial axial force values, the biomechanical response curve shapes of the THOR model show significant differences from the human lower limb model. CONCLUSION: Based on the present results, the Hybrid III dummy cannot be used to evaluate the lower limb injury risk in under-foot loading environments. In contrast, potential improvement in ankle biofidelity and related soft tissues of the THOR dummy can be implemented in the future for better applicability.

Benchmarking biomolecular force field-based Zn2+ for mono- and bimetallic ligand binding sites.

Zn2+ is one of the most versatile biologically available metal ions, but accurate modeling of Zn2+ -containing metalloproteins at the biomolecular force field level can be challenging. Since most Zn2+ models are parameterized in bulk solvent, in-depth knowledge about their performance in a protein environment is limited. Thus, we systematically investigate here the behavior of non-polarizable Zn2+ models for their ability to reproduce experimentally determined metal coordination and ligand binding in metalloproteins. The benchmarking is performed in challenging environments, including mono- (carbonic anhydrase II) and bimetallic (metallo-ß-lactamase VIM-2) ligand binding sites. We identify key differences in the performance between the Zn2+ models with regard to the preferred ligating atoms (charged/non-charged), attraction of water molecules, and the preferred coordination geometry. Based on these results, we suggest suitable simulation conditions for varying Zn2+ site geometries that could guide the further development of biomolecular Zn2+ models.

Two-Dimensional Living Supramolecular Polymerization: Improvement in Edge Roughness of Supramolecular Nanosheets by Using a Dummy Monomer.

Supramolecular polymers are formed through nucleation (i. e., initiation) and polymerization processes, and kinetic control over the nucleation process has recently led to the realization of living supramolecular polymerization. Changing the viewpoint, herein we focus on controlling the polymerization process, which we expect to pave the way to further developments in controlled supramolecular polymerization. In our previous study, two-dimensional living supramolecular polymerization was used to produce supramolecular nanosheets with a controlled area; however, these had rough edges. In this study, the growth of the nanosheets was controlled by using a 'dummy' monomer to produce supramolecular nanosheets with smoothed edges.

Design of a versatile and selective electrochemical sensor based on dummy molecularly imprinted PEDOT/laser-induced graphene for nitroaromatic explosives detection.

Considering the formidable explosive power and human carcinogenicity of nitroaromatic explosives, the implementation of an accurate and sensitive detection technology is imperative for ensuring public safety and monitoring post-blast environmental contamination. In the present work, a versatile and selective electrochemical sensor based on dummy molecularly imprinted poly (3,4-ethylenedioxythiophene)/laser-induced graphene (MIPEDOT/LIG) was successfully developed and the specific detection of multiple nitroaromatic explosives was realized in the single sensor. The accessible and nontoxic trimesic acid (TMA) and superior 3, 4-ethylenedioxythiophene (EDOT) were selected as the dummy-template and the functional monomer, respectively. The interaction between the functional monomer and the template, and the morphology, electrochemical properties and detection performance of the sensor were comprehensively investigated by ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, cyclic voltammetry, and differential pulse voltammetry. Benefiting from the alliance of TMA and EDOT, the MIPEDOT/LIG sensor manifested outstanding selectivity and sensitivity for 2,4,6-trinitrotolueen (TNT), 2,4,6-trinitrophenol (TNP), 2,4-dinitrotoluene (DNT), 1,3,5-trinitrobenzene (TNB), 2,4-dinitrophenol (DNP), and 1,3-dinitrobenzene (DNB) (representative nitroaromatic explosives) with limits of determination of 1.95 ppb, 3.06 ppb, 2.49 ppb, 1.67 ppb, 1.94 ppb, and 4.56 ppb, respectively. The sensor also exhibited extraordinary reliability and convenience for environmental sample detection. Therefore, a perfect combination of versatility and selectivity in the MIPEDOT/LIG sensor was achieved. The findings of this work provide a new direction for the development of multi-target electrochemical sensors using a versatile dummy template for explosives detection.

Dispersive solid phase extraction using a hydrophilic molecularly imprinted polymer for the selective extraction of patulin in apple juice samples.

A molecularly imprinted polymer with a specific selectivity for patulin was successfully synthesized. The molecularly imprinted material was prepared using the two functional monomers dopamine and melamine and formaldehyde as the cross-linker. The resulting material possessed a large number of hydrophilic groups, such as hydroxyls, imino groups, and ether linkages. For the first time, uric acid was used as a dummy template for its structural similarity to patulin. Comprehensive characterization and detailed studies of the adsorption process were carried out via adsorption isotherms, while the rate-limiting steps were investigated using adsorption kinetics. Separation, determination, and quantification of patulin were achieved by ultra-high performance liquid chromatography coupled with both photodiode array detection and tandem mass spectrometry. The latter was applied to patulin confirmation in the analysis of real samples. The methodology was validated in 20 apple juice samples. The results showed that the developed hydrophilic molecularly imprinted polymer had high selectivity and specific adsorption towards patulin, with mean recoveries ranging between 85 and 90% and a relative standard deviation lower than 15%. The developed molecularly imprinted polymer exhibited good linearity in the range 1-100 ng mL-1 with coefficient of determination (R2) > 0.99. The limit of detection was 0.5 ng mL-1, and the limit of quantification was 1 ng g-1. The developed method showed a good purification capacity for apple juices due to its hydrophilic nature and the polar interactions established with the target analyte.

Location Privacy-Preserving Scheme in IoBT Networks Using Deception-Based Techniques.

The Internet of Battlefield Things (IoBT) refers to interconnected battlefield equipment/sources for synchronized automated decision making. Due to difficulties unique to the battlefield, such as a lack of infrastructure, the heterogeneity of equipment, and attacks, IoBT networks differ significantly from regular IoT networks. In war scenarios, real-time location information gathering is critical for combat effectiveness and is dependent on network connectivity and information sharing in the presence of an enemy. To maintain connectivity and guarantee the safety of soldiers/equipment, location information must be exchanged. The location, identification, and trajectory of soldiers/devices are all contained in these messages. A malicious attacker may utilize this information to build a complete trajectory of a target node and track it. This paper proposes a location privacy-preserving scheme in IoBT networks using deception-based techniques. Dummy identifier (DID), sensitive areas location privacy enhancement, and silence period concepts are used to minimize the attacker's ability to track a target node. In addition, to consider the security of the location information, another security layer is proposed, which generates a pseudonym location for the source node to use instead of its real location when sending messages in the network. We develop a Matlab simulation to evaluate our scheme in terms of average anonymity and probability of linkability of the source node. The results show that the proposed method improves the anonymity of the source node. It reduces the attacker's ability to link the old DID of the source node with its new DID. Finally, the results show further privacy enhancement by applying the sensitive area concept, which is important for IoBT networks.

Honey Bee Larval Hemolymph as a Source of Key Nutrients and Proteins Offers a Promising Medium for Varroa destructor Artificial Rearing.

Varroa destructor, a major ectoparasite of the Western honey bee Apis mellifera, is a widespread pest that damages colonies in the Northern Hemisphere. Throughout their lifecycle, V. destructor females feed on almost every developmental stage of their host, from the last larval instar to the adult. The parasite is thought to feed on hemolymph and fat body, although its exact diet and nutritional requirements are poorly known. Using artificial Parafilm™ dummies, we explored the nutrition of V. destructor females and assessed their survival when fed on hemolymph from bee larvae, pupae, or adults. We compared the results with mites fed on synthetic solutions or filtered larval hemolymph. The results showed that the parasites could survive for several days or weeks on different diets. Bee larval hemolymph yielded the highest survival rates, and filtered larval plasma was sufficient to maintain the mites for 14 days or more. This cell-free solution therefore theoretically contains all the necessary nutrients for mite survival. Because some bee proteins are known to be hijacked without being digested by the parasite, we decided to run a proteomic analysis of larval honey bee plasma to highlight the most common proteins in our samples. A list of 54 proteins was compiled, including several energy metabolism proteins such as Vitellogenin, Hexamerin, or Transferrins. These molecules represent key nutrient candidates that could be crucial for V. destructor survival.

Body-kun/body-chan style model figures for artists in forensic visualization applications.

Posture and body position are often in the focus of forensic medicine. Visualization for the purposes of documentation, teaching, scientific presentation or expert opinion in court is often desired. Plenty of possible tools to support visualization are available. However, there is a significant gap between quick drawings and more complex techniques. Body-chan (female) and body-kun (male) artist's model figurines (genericized trademark) may provide a useful means to fill this gap. These models, about 12-15 cm in height, are multi-articulated humanoids of realistic proportions, intended to serve as models for manga (japanese comic) drawing. Plenty of different models are available in different quality which usually are equipped with interchangeable hand and feet attachments, a frame for 'levitating' positions as well as assorted objects to scale. These inexpensive models may be positioned quickly and intuitively. Photodocumentation from various angles can be performed using a mobile phone camera. Images may be further improved applying digital image manipulation software. Taken together, the process is quick and intuitive and the level of achievable complexity is sufficient for many forensic applications.

Comparison of Volunteers' Head Displacement with Computer Simulation-Crash Test with Low Speed of 20 km/h.

Recently, the automotive industry has used simulation programs much more often than experimental research. Computer simulations are more and more often used due to the repeatability of simulation conditions and the possibility of making modifications in simulation objects. Experimental and simulation studies carried out are aimed at developing a model of a simulation dummy adapted to both frontal and rear crash tests, taking into account changes in the moment of resistance in individual joints. The main purpose of the article is to reproduce a real crash test at a low speed of 20 km/h in a simulation program. For this purpose, a series of experimental crash tests with the participation of volunteers was carried out, and then a crash test with a dummy was simulated in the MSC ADAMS program. The experimental studies involved 100 volunteers who were divided into three percentile groups (C5, C50, C95). With the help of force sensors and a high-speed camera, crash tests of volunteers were recorded. The collected data from the force sensors made it possible to map the force in the seat belts. For low-speed crash tests, the displacement and acceleration of individual body parts of the dummy and volunteers can be measured using vision systems. The article identified head displacements of volunteers in the TEMA program based on a video analysis of a crash test film with a frequency of up to 2500 frames per second. The displacement of the simulation dummy's head in the MSC ADAMS program in the considered crash time interval from 0.0 to 0.4 s for all three percentile groups coincided with the head displacement of the volunteers during the experimental crash test.

A Survey of Dummy-Based Location Privacy Protection Techniques for Location-Based Services.

As smart devices and mobile positioning technologies improve, location-based services (LBS) have grown in popularity. The LBS environment provides considerable convenience to users, but it also poses a significant threat to their privacy. A large number of research works have emerged to protect users' privacy. Dummy-based location privacy protection solutions have been widely adopted for their simplicity and enhanced privacy protection results, but there are few reviews on dummy-based location privacy protection. Or, for existing works, some focus on aspects of cryptography, anonymity, or other comprehensive reviews that do not provide enough reviews on dummy-based privacy protection. In this paper, the authors provide a review of dummy-based location privacy protection techniques for location-based services. More specifically, the connection between the level of privacy protection, the quality of service, and the system overhead is summarized. The difference and connection between various location privacy protection techniques are also described. The dummy-based attack models are presented. Then, the algorithms for dummy location selection are analyzed and evaluated. Finally, we thoroughly evaluate different dummy location selection methods and arrive at a highly useful evaluation result. This result is valuable both to users and researchers who are studying this field.

Influence of a Passenger Position Seating on Recline Seat on a Head Injury during a Frontal Crash.

Presently, most passive safety tests are performed with a precisely specified seat position and carefully seated ATD (anthropomorphic test device) dummies. Facing the development of autonomous vehicles, as well as the need for safety verification during crashes with various seat positions such research is even more urgently needed. Apart from the numerical environment, the existing testing equipment is not validated to perform such an investigation. For example, ATDs are not validated for nonstandard seatback positions, and the most accurate method of such research is volunteer tests. The study presented here was performed on a sled test rig utilizing a 50cc Hybrid III dummy according to a full factorial experiment. In addition, input factors were selected in order to verify a safe test condition for surrogate testing. The measured value was head acceleration, which was used for calculation of a head injury criterion. What was found was an optimal seat angle -117°-at which the head injury criteria had the lowest represented value. Moreover, preliminary body dynamics showed a danger of whiplash occurrence for occupants in a fully-reclined seat.

A Vehicle Trajectory Privacy Preservation Method Based on Caching and Dummy Locations in the Internet of Vehicles.

In the internet of vehicles (IoVs), vehicle users should provide location information continuously when they want to acquire continuous location-based services (LBS), which may disclose the vehicle trajectory privacy. To solve the vehicle trajectory privacy leakage problem in the continuous LBS, we propose a vehicle trajectory privacy preservation method based on caching and dummy locations, abbreviated as TPPCD, in IoVs. In the proposed method, when a vehicle user wants to acquire a continuous LBS, the dummy locations-based location privacy preservation method under road constraint is used. Moreover, the cache is deployed at the roadside unit (RSU) to reduce the information interaction between vehicle users covered by the RSU and the LBS server. Two cache update mechanisms, the active cache update mechanism based on data popularity and the passive cache update mechanism based on dummy locations, are designed to protect location privacy and improve the cache hit rate. The performance analysis and simulation results show that the proposed vehicle trajectory privacy preservation method can resist the long-term statistical attack (LSA) and location correlation attack (LCA) from inferring the vehicle trajectory at the LBS server and protect vehicle trajectory privacy effectively. In addition, the proposed cache update mechanisms achieve a high cache hit rate.

Infant pacifier sanitization and risk of challenge-proven food allergy: A cohort study.

BACKGROUND: Environmental microbial exposure plays a role in immune system development and susceptibility to food allergy. OBJECTIVE: We sought to investigate whether infant pacifier use during the first postnatal year, with further consideration of sanitization, alters the risk of food allergy by age 1 year. METHODS: The birth cohort recruited pregnant mothers at under 28 weeks' gestation in southeast Australia, with 894 families followed up when infants turned 1 year. Infants were excluded if born under 32 weeks, with a serious illness, major congenital malformation, or genetic disease. Questionnaire data, collected at recruitment and infant ages 1, 6, and 12 months, included pacifier use and pacifier sanitization (defined as the joint exposure of a pacifier and cleaning methods). Challenge-proven food allergy was assessed at 12 months. RESULTS: Any pacifier use at 6 months was associated with food allergy (adjusted odds ratio, 1.94; 95% CI, 1.04-3.61), but not pacifier use at other ages. This overall association was driven by the joint exposure of pacifier-antiseptic use (adjusted odds ratio, 4.83; 95% CI, 1.10-21.18) compared with no pacifier use. Using pacifiers without antiseptic at 6 months was not associated with food allergy. Among pacifier users, antiseptic cleaning was still associated with food allergy (adjusted odds ratio, 3.56; 95% CI, 1.18-10.77) compared with no antiseptic use. Furthermore, persistent and repeated antiseptic use over the first 6 months was associated with higher food allergy risk (P = .029). CONCLUSIONS: This is the first report of a pacifier-antiseptic combination being associated with a higher risk of subsequent food allergy. Future work should investigate underlying biological pathways.

Determination of sulfonamide antibiotics in fish and shrimp samples based on magnetic carbon nanotube dummy molecularly imprinted polymer extraction followed by UPLC-MS/MS.

In this study, a novel purification method using magnetic solid-phase extraction (MSPE) based on magnetic carbon nanotube dummy molecularly imprinted polymer (MCNTMIP) nanocomposite was investigated for separation and enrichment of sulfonamide antibiotics (SAs) in fish and shrimp samples. The MCNTMIP nanocomposite was successfully synthesized by applying carbon nanotubes as supporting template, methacrylic acid as functional monomer, sulfabenzamide as the dummy template for SAs, and ethylene glycol dimethacrylate as crosslinking agent, then was characterized by Fourier-transform infrared spectrometry and vibrating sample magnetometry. The adsorption performance of MCNTMIP was evaluated by binding experiments, including static adsorption, kinetic adsorption, and selectivity recognition study. The results confirmed that an imprinted polymer layer was successfully constructed on the surface of the MCNTMIP and this sorbent has advantages of simple magnetic separation, specific molecular recognition, and high adsorption capacity. Combined with ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), we developed a rapid, sensitive, efficient MSPE method for detecting SAs analytes. Under the optimal conditions, the limits of detection were low to 0.1 µg/kg, and the recoveries of SAs analytes were ranged between 90.2 and 99.9%. In addition, the precision values were ranged between 0.5 and 9.1%. This method was successfully applied to analyze SAs in fish and shrimp samples with satisfactory recoveries.

Impact of prior and projected climate change on US Lyme disease incidence.

Lyme disease is the most common vector-borne disease in temperate zones and a growing public health threat in the United States (US). The life cycles of the tick vectors and spirochete pathogen are highly sensitive to climate, but determining the impact of climate change on Lyme disease burden has been challenging due to the complex ecology of the disease and the presence of multiple, interacting drivers of transmission. Here we incorporated 18 years of annual, county-level Lyme disease case data in a panel data statistical model to investigate prior effects of climate variation on disease incidence while controlling for other putative drivers. We then used these climate-disease relationships to project Lyme disease cases using CMIP5 global climate models and two potential climate scenarios (RCP4.5 and RCP8.5). We find that interannual variation in Lyme disease incidence is associated with climate variation in all US regions encompassing the range of the primary vector species. In all regions, the climate predictors explained less of the variation in Lyme disease incidence than unobserved county-level heterogeneity, but the strongest climate-disease association detected was between warming annual temperatures and increasing incidence in the Northeast. Lyme disease projections indicate that cases in the Northeast will increase significantly by 2050 (23,619 ± 21,607 additional cases), but only under RCP8.5, and with large uncertainty around this projected increase. Significant case changes are not projected for any other region under either climate scenario. The results demonstrate a regionally variable and nuanced relationship between climate change and Lyme disease, indicating possible nonlinear responses of vector ticks and transmission dynamics to projected climate change. Moreover, our results highlight the need for improved preparedness and public health interventions in endemic regions to minimize the impact of further climate change-induced increases in Lyme disease burden.

Preparation, evaluation, and application of dummy molecularly imprinted polymer for analysis of hesperidin in lime juice.

Lime juice as the most commonly used natural source production can be characterized using determination of flavonoids contents such as hesperidin. So, development of analyzing methods for checking the quality and healthiness of lime juices is necessary. In this study, we aimed to set up a selective solid phase extraction method using dummy molecularly imprinting approach for extraction and separation of hesperidin in lime juice to check the quality of commercial lime juice products of Mashhad city market. The imprinted polymers were synthesized by hesperitin as dummy template due to the hesperitin solubility in the wide range of porogenic solvents. The specificity extent of synthesized polymers toward hesperidin was tested and optimum one was used as adsorbent in solid-phase extraction cartridge. The dummy molecularly imprinted polymer with high adsorption capacity for hesperidin (dissociation constant 0.12 µM) was successfully used for extraction and clean-up of hesperidin in the lime juice matrix prior to analysis by high-performance liquid chromatography. The analysis of hesperidin was done in the range of 0.312-50 µg/mL with detection limit of 0.05 µg/mL. This technique was successfully set up to remove the interfering compounds for analysis of hesperidin in commercial lime juice products.