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1.

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.

Nieminuszczy, Jadwiga; Broderick, Ronan; Bellani, Marina A; Smethurst, Elizabeth; Schwab, Rebekka A; Cherdyntseva, Veronica; Evmorfopoulou, Theodora; Lin, Yea-Lih; Minczuk, Michal; Pasero, Philippe; Gagos, Sarantis; Seidman, Michael M; Niedzwiedz, Wojciech.

Mol Cell ; 75(3): 605-619.e6, 2019 08 08.

Artículo en Inglés | MEDLINE | ID: mdl-31255466

2.

Actin nucleators safeguard replication forks by limiting nascent strand degradation.

Nieminuszczy, Jadwiga; Martin, Peter R; Broderick, Ronan; Krwawicz, Joanna; Kanellou, Alexandra; Mocanu, Camelia; Bousgouni, Vicky; Smith, Charlotte; Wen, Kuo-Kuang; Woodward, Beth L; Bakal, Chris; Shackley, Fiona; Aguilera, Andrés; Stewart, Grant S; Vyas, Yatin M; Niedzwiedz, Wojciech.

Nucleic Acids Res ; 51(12): 6337-6354, 2023 07 07.

Artículo en Inglés | MEDLINE | ID: mdl-37224534

3.

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Coquel, Flavie; Silva, Maria-Joao; Técher, Hervé; Zadorozhny, Karina; Sharma, Sushma; Nieminuszczy, Jadwiga; Mettling, Clément; Dardillac, Elodie; Barthe, Antoine; Schmitz, Anne-Lyne; Promonet, Alexy; Cribier, Alexandra; Sarrazin, Amélie; Niedzwiedz, Wojciech; Lopez, Bernard; Costanzo, Vincenzo; Krejci, Lumir; Chabes, Andrei; Benkirane, Monsef; Lin, Yea-Lih; Pasero, Philippe.

Nature ; 557(7703): 57-61, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29670289

4.

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford, Andrew N; Nieminuszczy, Jadwiga; Schwab, Rebekka A; Galanty, Yaron; Jackson, Stephen P; Niedzwiedz, Wojciech.

Mol Cell ; 57(6): 1133-1141, 2015 Mar 19.

Artículo en Inglés | MEDLINE | ID: mdl-25794620

5.

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.

Schwab, Rebekka A; Nieminuszczy, Jadwiga; Shah, Fenil; Langton, Jamie; Lopez Martinez, David; Liang, Chih-Chao; Cohn, Martin A; Gibbons, Richard J; Deans, Andrew J; Niedzwiedz, Wojciech.

Mol Cell ; 60(3): 351-61, 2015 Nov 05.

Artículo en Inglés | MEDLINE | ID: mdl-26593718

6.

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs, Martin R; Reynolds, John J; Winczura, Alicja; Blackford, Andrew N; Borel, Valérie; Miller, Edward S; Zlatanou, Anastasia; Nieminuszczy, Jadwiga; Ryan, Ellis L; Davies, Nicholas J; Stankovic, Tatjana; Boulton, Simon J; Niedzwiedz, Wojciech; Stewart, Grant S.

Mol Cell ; 59(3): 462-77, 2015 Aug 06.

Artículo en Inglés | MEDLINE | ID: mdl-26166705

7.

Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.

Fenwick, Aimee L; Kliszczak, Maciej; Cooper, Fay; Murray, Jennie; Sanchez-Pulido, Luis; Twigg, Stephen R F; Goriely, Anne; McGowan, Simon J; Miller, Kerry A; Taylor, Indira B; Logan, Clare; Bozdogan, Sevcan; Danda, Sumita; Dixon, Joanne; Elsayed, Solaf M; Elsobky, Ezzat; Gardham, Alice; Hoffer, Mariette J V; Koopmans, Marije; McDonald-McGinn, Donna M; Santen, Gijs W E; Savarirayan, Ravi; de Silva, Deepthi; Vanakker, Olivier; Wall, Steven A; Wilson, Louise C; Yuregir, Ozge Ozalp; Zackai, Elaine H; Ponting, Chris P; Jackson, Andrew P; Wilkie, Andrew O M; Niedzwiedz, Wojciech; Bicknell, Louise S.

Am J Hum Genet ; 99(1): 125-38, 2016 07 07.

Artículo en Inglés | MEDLINE | ID: mdl-27374770

8.

The DNA fibre technique - tracking helicases at work.

Nieminuszczy, Jadwiga; Schwab, Rebekka A; Niedzwiedz, Wojciech.

Methods ; 108: 92-8, 2016 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-27102626

9.

The DNA translocase activity of FANCM protects stalled replication forks.

Blackford, Andrew N; Schwab, Rebekka A; Nieminuszczy, Jadwiga; Deans, Andrew J; West, Stephen C; Niedzwiedz, Wojciech.

Hum Mol Genet ; 21(9): 2005-16, 2012 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-22279085

10.

ATR activation and replication fork restart are defective in FANCM-deficient cells.

Schwab, Rebekka A; Blackford, Andrew N; Niedzwiedz, Wojciech.

EMBO J ; 29(4): 806-18, 2010 Feb 17.

Artículo en Inglés | MEDLINE | ID: mdl-20057355

11.

"Dub"bing a tumor suppressor pathway.

Niedzwiedz, Wojciech; Patel, Ketan J.

Cancer Cell ; 7(2): 114-5, 2005 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-15710323

12.

Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity.

Broderick, Ronan; Cherdyntseva, Veronica; Nieminuszczy, Jadwiga; Dragona, Eleni; Kyriakaki, Maria; Evmorfopoulou, Theodora; Gagos, Sarantis; Niedzwiedz, Wojciech.

Nat Commun ; 14(1): 2428, 2023 04 27.

Artículo en Inglés | MEDLINE | ID: mdl-37105990

13.

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress.

Sandoz, Jérémy; Cigrang, Max; Zachayus, Amélie; Catez, Philippe; Donnio, Lise-Marie; Elly, Clèmence; Nieminuszczy, Jadwiga; Berico, Pietro; Braun, Cathy; Alekseev, Sergey; Egly, Jean-Marc; Niedzwiedz, Wojciech; Giglia-Mari, Giuseppina; Compe, Emmanuel; Coin, Frédéric.

Nat Commun ; 14(1): 341, 2023 01 20.

Artículo en Inglés | MEDLINE | ID: mdl-36670096

14.

Actin nucleators safeguard replication forks by limiting nascent strand degradation.

Nieminuszczy, Jadwiga; Martin, Peter R; Broderick, Ronan; Krwawicz, Joanna; Kanellou, Alexandra; Mocanu, Camelia; Bousgouni, Vicky; Smith, Charlotte; Wen, Kuo-Kuang; Woodward, Beth L; Bakal, Chris; Shackley, Fiona; Aguilera, Andres; Stewart, Grant S; Vyas, Yatin M; Niedzwiedz, Wojciech.

bioRxiv ; 2023 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-36711944

15.

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.

Bland, Philip; Saville, Harry; Wai, Patty T; Curnow, Lucinda; Muirhead, Gareth; Nieminuszczy, Jadwiga; Ravindran, Nivedita; John, Marie Beatrix; Hedayat, Somaieh; Barker, Holly E; Wright, James; Yu, Lu; Mavrommati, Ioanna; Read, Abigail; Peck, Barrie; Allen, Mark; Gazinska, Patrycja; Pemberton, Helen N; Gulati, Aditi; Nash, Sarah; Noor, Farzana; Guppy, Naomi; Roxanis, Ioannis; Pratt, Guy; Oldreive, Ceri; Stankovic, Tatjana; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah E; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti S; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J; Natrajan, Rachael.

Nat Genet ; 55(8): 1311-1323, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37524790

16.

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.

Han, Seong-Su; Wen, Kuo-Kuang; García-Rubio, María L; Wold, Marc S; Aguilera, Andrés; Niedzwiedz, Wojciech; Vyas, Yatin M.

Nat Commun ; 13(1): 3743, 2022 06 29.

Artículo en Inglés | MEDLINE | ID: mdl-35768435

17.

Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal.

Hodson, Charlotte; van Twest, Sylvie; Dylewska, Malgorzata; O'Rourke, Julienne J; Tan, Winnie; Murphy, Vincent J; Walia, Mannu; Abbouche, Lara; Nieminuszczy, Jadwiga; Dunn, Elyse; Bythell-Douglas, Rohan; Heierhorst, Jörg; Niedzwiedz, Wojciech; Deans, Andrew J.

Cell Rep ; 41(10): 111749, 2022 12 06.

Artículo en Inglés | MEDLINE | ID: mdl-36476850

18.

Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress.

Kalogeropoulou, Argyro; Mougkogianni, Maria; Iliadou, Marianna; Nikolopoulou, Eleni; Flordelis, Stefanos; Kanellou, Alexandra; Arbi, Marina; Nikou, Sofia; Nieminuszczy, Jadwiga; Niedzwiedz, Wojciech; Kardamakis, Dimitrios; Bravou, Vasiliki; Lygerou, Zoi; Taraviras, Stavros.

Stem Cell Reports ; 17(6): 1395-1410, 2022 06 14.

Artículo en Inglés | MEDLINE | ID: mdl-35623353

19.

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.

Llorca-Cardenosa, Marta J; Aronson, Lauren I; Krastev, Dragomir B; Nieminuszczy, Jadwiga; Alexander, John; Song, Feifei; Dylewska, Malgorzata; Broderick, Ronan; Brough, Rachel; Zimmermann, Astrid; Zenke, Frank T; Gurel, Bora; Riisnaes, Ruth; Ferreira, Ana; Roumeliotis, Theodoros; Choudhary, Jyoti; Pettitt, Stephen J; de Bono, Johann; Cervantes, Andres; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J; Chong, Irene Y.

Cancer Res ; 82(21): 3962-3973, 2022 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-36273494

20.

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair.

Rosado, Ivan V; Niedzwiedz, Wojciech; Alpi, Arno F; Patel, Ketan J.

Nucleic Acids Res ; 37(13): 4360-70, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19465393

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EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.

Actin nucleators safeguard replication forks by limiting nascent strand degradation.

SAMHD1 acts at stalled replication forks to prevent interferon induction.

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.

The DNA fibre technique - tracking helicases at work.

The DNA translocase activity of FANCM protects stalled replication forks.

ATR activation and replication fork restart are defective in FANCM-deficient cells.

"Dub"bing a tumor suppressor pathway.

Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity.

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress.

Actin nucleators safeguard replication forks by limiting nascent strand degradation.

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.

Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal.

Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress.

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair.