Lead/Lag directionality is not generally equivalent to causality in nonlinear systems: Comparison of phase slope index and conditional mutual information.

Applications of causal techniques to neural time series have increased extensively over last decades, including a wide and diverse family of methods focusing on electroencephalogram (EEG) analysis. Besides connectivity inferred in defined frequency bands, there is a growing interest in the analysis of cross-frequency interactions, in particular phase and amplitude coupling and directionality. Some studies show contradicting results of coupling directionality from high frequency to low frequency signal components, in spite of generally considered modulation of a high-frequency amplitude by a low-frequency phase. We have compared two widely used methods to estimate the directionality in cross frequency coupling: conditional mutual information (CMI) and phase slope index (PSI). The latter, applied to infer cross-frequency phase-amplitude directionality from animal intracranial recordings, gives opposite results when comparing to CMI. Both metrics were tested in a numerically simulated example of unidirectionally coupled Rössler systems, which helped to find the explanation of the contradictory results: PSI correctly estimates the lead/lag relationship which, however, is not generally equivalent to causality in the sense of directionality of coupling in nonlinear systems, correctly inferred by using CMI with surrogate data testing.

Predefined-Time Adaptive Neural Tracking Control for a Single Link Manipulator with an Event-Triggered Mechanism.

This paper introduces an adaptive trajectory-tracking control method for uncertain nonlinear systems, leveraging a time-varying threshold event-triggered mechanism to achieve predefined-time tracking. Compared to conventional time-triggering approaches, the employment of a time-varying threshold event-triggered mechanism significantly curtails communication resource wastage without compromising the system's performance. Furthermore, a novel adaptive control algorithm with predefined timing is introduced. This method guarantees that tracking errors converge to within a small vicinity of the origin within a predefined timeframe, ensuring all signals in the closed-loop system remain bounded. Moreover, by adjusting a controller-related parameter, we can predefine the upper bound of the convergence time. Finally, the efficacy of the control scheme is corroborated by simulation results obtained from a nonlinear manipulator system.

A Joint State and Fault Estimation Scheme for State-Saturated System with Energy Harvesting Sensors.

In this article, the issue of joint state and fault estimation is ironed out for delayed state-saturated systems subject to energy harvesting sensors. Under the effect of energy harvesting, the sensors can harvest energy from the external environment and consume an amount of energy when transmitting measurements to the estimator. The occurrence probability of measurement loss is computed at each instant according to the probability distribution of the energy harvesting mechanism. The main objective of the addressed problem is to construct a joint state and fault estimator where the estimation error covariance is ensured in some certain sense and the estimator gain is determined to accommodate energy harvesting sensors, state saturation, as well as time delays. By virtue of a set of matrix difference equations, the derived upper bound is minimized by parameterizing the estimator gain. In addition, the performance evaluation of the designed joint estimator is conducted by analyzing the boundedness of the estimation error in the mean-squared sense. Finally, two experimental examples are employed to illustrate the feasibility of the proposed estimation scheme.

Optimal Robust Control of Nonlinear Systems with Unknown Dynamics via NN Learning with Relaxed Excitation.

This paper presents an adaptive learning structure based on neural networks (NNs) to solve the optimal robust control problem for nonlinear continuous-time systems with unknown dynamics and disturbances. First, a system identifier is introduced to approximate the unknown system matrices and disturbances with the help of NNs and parameter estimation techniques. To obtain the optimal solution of the optimal robust control problem, a critic learning control structure is proposed to compute the approximate controller. Unlike existing identifier-critic NNs learning control methods, novel adaptive tuning laws based on Kreisselmeier's regressor extension and mixing technique are designed to estimate the unknown parameters of the two NNs under relaxed persistence of excitation conditions. Furthermore, theoretical analysis is also given to prove the significant relaxation of the proposed convergence conditions. Finally, effectiveness of the proposed learning approach is demonstrated via a simulation study.

Wireless-Channel Key Distribution Based on Laser Synchronization.

We propose and experimentally demonstrate a wireless-channel key distribution scheme based on laser synchronization induced by a common wireless random signal. Two semiconductor lasers are synchronized under injection of the drive signal after electrical-optical conversion and emit irregular outputs that are used to generate shared keys. Our proof-of-concept experiment using a complex drive signal achieved a secure key generation rate of up to 150 Mbit/s with a bit error rate below 3.8 × 10-3. Numerical simulation results show that the proposed scheme has the potential to achieve a distribution distance of several hundred meters. It is believed that common-signal-induced laser synchronization paves the way for high-speed wireless physical-layer key distribution.

Event-Triggered Robust State Estimation for Nonlinear Networked Systems with Measurement Delays against DoS Attacks.

In this paper, we focus on the event-triggered robust state estimation problems for nonlinear networked systems with constant measurement delays against denial-of-service (DoS) attacks. The computation of the extended Kalman filter (EKF) generates errors of linearization approximations, which can result in increased state estimation errors, and subsequently amplifies the linearization errors. DoS attacks interfere with the transmission of measurements sent to the remote robust state estimator by overloading the communication networks, while the communication rate of the communication channel is constrained. Therefore, an event-triggered robust state estimation algorithm based on sensitivity penalization with an explicit packet arrival parameter is derived to defend against DoS attacks and linearization errors. Meanwhile, the presence of measurement delays precludes the direct use of conventional state estimation algorithms, prompting us to devise an innovative state augmentation method. The results of the numerical simulations show that the proposed robust state estimator can appreciably improve the accuracy of state estimation.

Critic Learning-Based Safe Optimal Control for Nonlinear Systems with Asymmetric Input Constraints and Unmatched Disturbances.

In this paper, the safe optimal control method for continuous-time (CT) nonlinear safety-critical systems with asymmetric input constraints and unmatched disturbances based on the adaptive dynamic programming (ADP) is investigated. Initially, a new non-quadratic form function is implemented to effectively handle the asymmetric input constraints. Subsequently, the safe optimal control problem is transformed into a two-player zero-sum game (ZSG) problem to suppress the influence of unmatched disturbances, and a new Hamilton-Jacobi-Isaacs (HJI) equation is introduced by integrating the control barrier function (CBF) with the cost function to penalize unsafe behavior. Moreover, a damping factor is embedded in the CBF to balance safety and optimality. To obtain a safe optimal controller, only one critic neural network (CNN) is utilized to tackle the complex HJI equation, leading to a decreased computational load in contrast to the utilization of the conventional actor-critic network. Then, the system state and the parameters of the CNN are uniformly ultimately bounded (UUB) through the application of the Lyapunov stability method. Lastly, two examples are presented to confirm the efficacy of the presented approach.

Data-driven prediction of COVID-19 cases in Germany for decision making.

BACKGROUND: The COVID-19 pandemic has led to a high interest in mathematical models describing and predicting the diverse aspects and implications of the virus outbreak. Model results represent an important part of the information base for the decision process on different administrative levels. The Robert-Koch-Institute (RKI) initiated a project whose main goal is to predict COVID-19-specific occupation of beds in intensive care units: Steuerungs-Prognose von Intensivmedizinischen COVID-19 Kapazitäten (SPoCK). The incidence of COVID-19 cases is a crucial predictor for this occupation. METHODS: We developed a model based on ordinary differential equations for the COVID-19 spread with a time-dependent infection rate described by a spline. Furthermore, the model explicitly accounts for weekday-specific reporting and adjusts for reporting delay. The model is calibrated in a purely data-driven manner by a maximum likelihood approach. Uncertainties are evaluated using the profile likelihood method. The uncertainty about the appropriate modeling assumptions can be accounted for by including and merging results of different modelling approaches. The analysis uses data from Germany describing the COVID-19 spread from early 2020 until March 31st, 2021. RESULTS: The model is calibrated based on incident cases on a daily basis and provides daily predictions of incident COVID-19 cases for the upcoming three weeks including uncertainty estimates for Germany and its subregions. Derived quantities such as cumulative counts and 7-day incidences with corresponding uncertainties can be computed. The estimation of the time-dependent infection rate leads to an estimated reproduction factor that is oscillating around one. Data-driven estimation of the dark figure purely from incident cases is not feasible. CONCLUSIONS: We successfully implemented a procedure to forecast near future COVID-19 incidences for diverse subregions in Germany which are made available to various decision makers via an interactive web application. Results of the incidence modeling are also used as a predictor for forecasting the need of intensive care units.

DEGBOE: Discrete time Evolution modeling of Gene mutation through Bayesian inference using qualitative Observation of mutation Events.

An important aspect of cancer progression concerns the way in which gene mutations accumulate in cellular lineages. Comprehensive efforts into cataloging cancer genes have revealed that tumors demonstrate variability in genes that accumulate mutations which depend on the presence or absence of other mutations. However, understanding the stochastic process by which mutations arise across the genome is an important open problem of this nature in biology due to modeling discrete variate time-series is the most challenging, and, as yet, least well-developed of all areas of research in time-series. In this paper, a DEGBOE framework is proposed to model the mutation time-series given the sequence data of the gene mutations. The method relates the discrete-time, nonlinear and nonstationary series of gene mutations to the time-varying autoregressive moving average model. It presents the observation as a nonlinear function dependent on two variables: gene mutation, and gene-gene interactions characterizing the effects of the varying presence or absence of other gene mutations on a mutations' occurrence and evolution. DEGBOE is applied to model the dynamics of frequently mutated genes in lung cancer, includingEGFR,KRAS, and TP53. The results of the model are analyzed and compared to the original simulated data of theDNAwalk, and experimental lung cancer mutations data. It identifies the driver role of TP53 mutations in lung cancer progression.

A Simplified Algorithm for Setting the Observer Parameters for Second-Order Systems with Persistent Disturbances Using a Robust Observer.

The properties of the convergence region of the estimation error of a robust observer for second-order systems are determined, and a new algorithm is proposed for setting the observer parameters, considering persistent but bounded disturbances in the two observation error dynamics. The main contributions over closely related studies of the stability of state observers are: (i) the width of the convergence region of the observer error for the unknown state is expressed in terms of the interaction between the observer parameters and the disturbance terms of the observer error dynamics; (ii) it was found that this width has a minimum point and a vertical asymptote with respect to one of the observer parameters, and their coordinates were determined. In addition, the main advantages of the proposed algorithm over closely related algorithms are: (i) the definition of observer parameters is significantly simpler, as the fulfillment of Riccati equation conditions, solution of LMI constraints, and fulfillment of eigenvalue conditions are not required; (ii) unknown bounded terms are considered in the dynamics of the observer error for the known state. Finally, the algorithm is applied to a model of microalgae culture in a photobioreactor for the estimation of biomass growth rate and substrate uptake rate based on known concentrations of biomass and substrate.

Mid-State Kalman Filter for Nonlinear Problems.

When tracking very long-range targets, wide-band radars capable of measuring targets with high precision at ranges have severe measurement nonlinearities. The existing nonlinear filtering technology, such as the extended Kalman filter and untracked Kalman filter, will have significant consistency problems and loss in tracking accuracy. A novel mid-state Kalman filter is proposed to avoid loss and preserve the filtering consistency. The observed state and its first-order state derivative are selected as the mid-state vector. The update process is transformed into the measurement space to ensure the Gaussian measurement distribution and the linearization of the measurement equation. In order to verify the filter performance in comparison, an iterative formulation of Cramér-Rao Low Bound for the nonlinear system is further derived and given in this paper. Simulation results show that the proposed method has excellent performance of high filtering accuracy and fast convergence by comparing the filter state estimation accuracy and consistency.

The Improved WNOFRFs Feature Extraction Method and Its Application to Quantitative Diagnosis for Cracked Rotor Systems.

During its operation, a rotor system can be exposed to multiple faults, such as rub-impact, misalignment, cracks and unbalancing. When a crack fault occurs on the rotor shaft, the vibration response signals contain some nonlinear components that are considerably tougher to be extracted through some linear diagnosis methods. By combining the Nonlinear Output Frequency Response Functions weighted contribution rate (WNOFRFs) and Kullback-Leibler (KL) divergence, a novel fault diagnosis method of improved WNOFRFs is proposed. In this method, an index, improved optimal WNOFRFs (IOW), is defined to represent the nonlinearity of the faulty rotor system. This method has been tested through the finite element model of a cracked rotor system and then verified experimentally at the shaft crack detection test bench. The results from the simulation and experiment verified that the proposed method is applicable and effective for cracked rotor systems. The IOW indicator shows high sensitivity to crack faults and can comprehensively represent the nonlinear properties of the system. It can also quantitatively detect the crack fault, and the relationship between the values of IOW and the relative depth of the crack is approximately positively proportional. The proposed method can precisely and quantitatively diagnose crack faults in a rotor system.

Fault Identification in Electric Servo Actuators of Robot Manipulators Described by Nonstationary Nonlinear Dynamic Models Using Sliding Mode Observers.

The problem of fault identification in electric servo actuators of robot manipulators described by nonstationary nonlinear dynamic models under disturbances is considered. To solve the problem, sliding mode observers are used. The suggested approach is based on the reduced order model of the original system having different sensitivity to faults and disturbances. This model is realized in canonical form that enables relaxing the limitation imposed on the original system. Theoretical results are illustrated by practical example.

RBF Neural Network Sliding Mode Control for Passification of Nonlinear Time-Varying Delay Systems with Application to Offshore Cranes.

This paper is devoted to studying the passivity-based sliding mode control for nonlinear systems and its application to dock cranes through an adaptive neural network approach, where the system suffers from time-varying delay, external disturbance and unknown nonlinearity. First, relying on the generalized Lagrange formula, the mathematical model for the crane system is established. Second, by virtue of an integral-type sliding surface function and the equivalent control theory, a sliding mode dynamic system can be obtained with a satisfactory dynamic property. Third, based on the RBF neural network approach, an adaptive control law is designed to ensure the finite-time existence of sliding motion in the face of unknown nonlinearity. Fourth, feasible easy-checking linear matrix inequality conditions are developed to analyze passification performance of the resulting sliding motion. Finally, a simulation study is provided to confirm the validity of the proposed method.

Introducing a Novel Model-Free Multivariable Adaptive Neural Network Controller for Square MIMO Systems.

In this study, a novel Multivariable Adaptive Neural Network Controller (MANNC) is developed for coupled model-free n-input n-output systems. The learning algorithm of the proposed controller does not rely on the model of a system and uses only the history of the system inputs and outputs. The system is considered as a 'black box' with no pre-knowledge of its internal structure. By online monitoring and possessing the system inputs and outputs, the parameters of the controller are adjusted. Using the accumulated gradient of the system error along with the Lyapunov stability analysis, the weights' adjustment convergence of the controller can be observed, and an optimal training number of the controller can be selected. The Lyapunov stability of the system is checked during the entire weight training process to enable the controller to handle any possible nonlinearities of the system. The effectiveness of the MANNC in controlling nonlinear square multiple-input multiple-output (MIMO) systems is demonstrated via three simulation studies covering the cases of a time-invariant nonlinear MIMO system, a time-variant nonlinear MIMO system, and a hybrid MIMO system, respectively. In each case, the performance of the MANNC is compared with that of a properly selected existing counterpart. Simulation results demonstrate that the proposed MANNC is capable of controlling various types of square MIMO systems with much improved performance over its existing counterpart. The unique properties of the MANNC will make it a suitable candidate for many industrial applications.

Synthetic Stochastic Motion Platform for Testing Single Particle Tracking Microscopes.

We describe the design and implementation of a control system for testing the performance of single particle tracking microscopes with the method of synthetic motion. Single particle tracking (SPT) has become a common and powerful tool in the study of biomolecular transport in cellular biology, providing the ability to track individual biological macromolecules in their native environment. Existing methods for testing SPT techniques rely on physical simulations and there is a clear need for experimental-based schemes for both comparing different approaches and for characterizing the accuracy and precision of techniques on particular experimental setups. Synthetic motion, that is, using an actuator such as a nanopositioning stage to drive a particle along a known ground-truth trajectory, is a means for achieving these ends. However, the resolution, accuracy, and flexibility of this method is limited by the actuator static and dynamic characteristics. In this work we apply system identification and model inverse feedforward control to increase actuator bandwidth and address some common actuator nonlinearities, develop a set of dimensionless numbers that describe system limitations, and provide a set of guidelines for the practical use of synthetic motion in SPT.

Coherence and Anticoherence Induced by Thermal Fields.

Interesting coherence and correlations appear between superpositions of two bosonic modes when the modes are parametrically coupled to a third intermediate mode and are also coupled to external modes which are in thermal states of unequal mean photon numbers. Under such conditions, it is found that one of linear superpositions of the modes, which is effectively decoupled from the other modes, can be perfectly coherent with the other orthogonal superposition of the modes and can simultaneously exhibit anticoherence with the intermediate mode, which can give rise to entanglement between the modes. It is shown that the coherence effects have a substantial effect on the population distribution between the modes, which may result in lowering the population of the intermediate mode. This shows that the system can be employed to cool modes to lower temperatures. Furthermore, for appropriate thermal photon numbers and coupling strengths between the modes, it is found that entanglement between the directly coupled superposition and the intermediate modes may occur in a less restricted range of the number of the thermal photons such that the modes could be strongly entangled, even at large numbers of the thermal photons.

Modeling and Simulation of an Energy Integrated Distillation Column in a Bond Graph Approach.

The bond graph methodology for modelling an integrated energy distillation column is applied in this paper. The distillation column is built by five trays for a binary mixture. However, due to its modular construction in a bond graph, the number of trays can be increased. In order to link the analysis tools of systems modeled in the bond graph to the mathematical model given to a distillation column, a junction structure of the proposed bond graph is presented. Hence, this junction structure is a way to obtain the state space representation of the modeled column in bond graphs. Likewise, it is well known that distillation columns determine a class of nonlinear systems, so throughout this paper, these systems in a bond graph approach can be analyzed. In order to learn the behavior of the distillation column in the physical domain, simulation results using 20-Sim software are shown. In addition, with the simulation of two case studies consisting of two mixtures with different relative volatilities, the versatility of the column model in a bond graph is presented. In both cases, the increase in the feed flow, the mole fraction of the light component in the feed or the distillate reflux that enriches the concentration of light in the column determine an increase in the mole fraction of light in the distillate and in the bottom reflow. Further, the control design for a distillation column in the physical domain can be extended.

Adaptive Fixed-Time Neural Networks Control for Pure-Feedback Non-Affine Nonlinear Systems with State Constraints.

A new fixed-time adaptive neural network control strategy is designed for pure-feedback non-affine nonlinear systems with state constraints according to the feedback signal of the error system. Based on the adaptive backstepping technology, the Lyapunov function is designed for each subsystem. The neural network is used to identify the unknown parameters of the system in a fixed-time, and the designed control strategy makes the output signal of the system track the expected signal in a fixed-time. Through the stability analysis, it is proved that the tracking error converges in a fixed-time, and the design of the upper bound of the setting time of the error system only needs to modify the parameters and adaptive law of the controlled system controller, which does not depend on the initial conditions.

An Enhanced Full-Form Model-Free Adaptive Controller for SISO Discrete-Time Nonlinear Systems.

This study focuses on the full-form model-free adaptive controller (FFMFAC) for SISO discrete-time nonlinear systems, and proposes enhanced FFMFAC. The proposed technique design incorporates long short-term memory neural networks (LSTMs) and fuzzy neural networks (FNNs). To be more precise, LSTMs are utilized to adjust vital parameters of the FFMFAC online. Additionally, due to the high nonlinear approximation capabilities of FNNs, pseudo gradient (PG) values of the controller are estimated online. EFFMFAC is characterized by utilizing the measured I/O data for the online training of all introduced neural networks and does not involve offline training and specific models of the controlled system. Finally, the rationality and superiority are verified by two simulations and a supporting ablation analysis. Five individual performance indices are given, and the experimental findings show that EFFMFAC outperforms all other methods. Especially compared with the FFMFAC, EFFMFAC reduces the RMSE by 21.69% and 11.21%, respectively, proving it to be applicable for SISO discrete-time nonlinear systems.