1.
Bioorg Med Chem Lett
; 13(24): 4381-4, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14643330
RESUMO
A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel melatoninergic ligands. Binding affinity assays were performed on cloned human MT(1) and MT(2) receptors, stably expressed in NIH3T3 cells. Compound 16 was identified as an orally bioavailable agonist at MT(1) and MT(2) melatonin receptors with low vasoconstrictive activity.