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Bioorg Med Chem Lett
; 18(3): 938-41, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18221871
RESUMO
Optimization of pyrazinoindolone inhibitors of MAPKAP-K2 (MK2) provides a reasonable balance of cellular potency and physicochemical properties. Mechanistic studies support the inhibition of MK2 which is responsible for the sub-micromolar cellular efficacy.