Cyclic voltammetric studies of Gemifloxacin using Gold electrode in presence of Britton-Robinson Buffer.

The electrochemical study of the Gemifloxacin has been conducted using cyclic voltammetry technique at gold electrode. Gemifloxacin is antibacterial compound. In present study the electrochemical parameters of Gemifloxacin were determined in (0.04M) Britton Robinson Buffer as a supporting electrolyte at different pH ranging from 2-6 pH. This buffer was selected according to the appropriate solubility of these pharmaceutical compounds. Voltammograms of Gemifloxacin have been recorded at six different scan rates of 20, 100, 200, 300, 400 and 500mV/s. Different electrochemical parameters such as peak potential (Ep), peak current (Ip), transfer coefficient (α), number of electron (nα), diffusion coefficient (D), and heterogeneous rate constant (K0) were determined. Moreover, diagnostics tests have also been applied to define the electrochemical behavior of Gemifloxacin showed quasi reversible redox process with two electron transfers at the electrode.

Cyclic voltammetric study of alpha-methyldopa at carbon paste electrode.

The cyclic voltammetric behaviour of alpha-methyldopa at a silicon oil carbon paste electrode has been reported. This allowed the development of a quantitative method to determine alpha-methyldopa in LiCl, KCl, NaCl, HCl, H2SO4 and CH3COOH as supporting electrolytes. For qualitative characteristics, alpha-methyldopa showed an ECC mechanism in terms of electron transfer reaction (placing it in DPI zone) at carbon paste electrode. The values of transfer coefficients alpha and beta were determined. The larger DeltaEp values were obtained due to the use of unmodified carbon paste electrode (CPE) has decreased the rate of electron transfer at the surface of the test electrode. The first order rate constant values (ko) were within 0.10-7.78 +/- 0.1x10(-3) s(-1). Adsorption of analyte was also determined at CPE using repeated scan method.