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1.
Ultrasonics ; 116: 106495, 2021 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-34186322

RESUMO

This work aims to describe the development and validation of two low-intensity pulsed ultrasound stimulation systems able to control the dose delivered to the biological target. Transducer characterization was performed in terms of pressure field shape and intensity, for a high-frequency range (500 kHz to 5 MHz) and for a low-frequency value (38 kHz). This allowed defining the distance, on the beam axis, at which biological samples should be placed during stimulation and to exactly know the intensity at the target. Carefully designed retaining systems were developed, for hosting biological samples. Sealing tests proved their impermeability to external contaminants. The assembly/de-assembly time of the systems resulted ~3 min. Time-domain acoustic simulations allowed to precisely estimate the ultrasound beam within the biological sample chamber, thus enabling the possibility to precisely control the pressure to be transmitted to the biological target, by modulating the transducer's input voltage. Biological in vitro tests were also carried out, demonstrating the sterility of the system and the absence of toxic and inflammatory effects on growing cells after multiple immersions in water, over seven days.

2.
Int J Tissue React ; 8(2): 167-74, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-2939036

RESUMO

A clinical study was performed on nine adult in-patients suffering from chronic intercrisis bronchopneumopathy, to evaluate whether a local endobronchial treatment with ambroxol could be effective in stabilizing the secretory activity of bronchial glands modified by phlogistic injury. The patients underwent bronchoscopic examination and deep biopsy, before and after treatment with local medication of ambroxol every other day for 30 days. In addition to morphometric measurements, detailed histochemical examinations were performed on the secretion of mucous acinic and glandular excretory ducts. The trial proved that the treatment with ambroxol stimulates serous acini, restoring normal production of sulphomucins and also of mucous acini, increasing the metabolic activities of acid glycoproteins and proportionally curtailing the excessive synthesis of glycoproteins. Ambroxol can therefore be considered a mucoregulating drug.


Assuntos
Ambroxol/farmacologia , Bromoexina/análogos & derivados , Brônquios/efeitos dos fármacos , Bronquite/tratamento farmacológico , Mucinas/metabolismo , Adulto , Idoso , Ambroxol/uso terapêutico , Biópsia , Brônquios/patologia , Bronquite/patologia , Broncoscopia , Doença Crônica , Glândulas Exócrinas/efeitos dos fármacos , Glândulas Exócrinas/metabolismo , Glândulas Exócrinas/patologia , Feminino , Glicoproteínas/biossíntese , Glicoproteínas/metabolismo , Glicosaminoglicanos/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa/efeitos dos fármacos , Mucosa/metabolismo , Mucosa/patologia , Sialomucinas
3.
Minerva Cardioangiol ; 39(1-2): 47-53, 1991.
Artigo em Italiano | MEDLINE | ID: mdl-1857510

RESUMO

The Authors describe a case of uniatrial univentricular heart with a right transposition and atresia of the aorta. This case forms part of an autoptic series of 74 congenital cardiopathies with defects of the septal system: monometameric (52 cases), polymetameric (22 cases), and limited (66 cases) or broad DIA, DIV or FAP types (8 cases). Having outlined the correlations between the type of defect and the complex morphogenetic events, whose close integration leads to a continuous septal system, the Authors focus their attention on the common associations between septal defects and other cardio-vascular anomalies (66 cases). The analysis of findings supports hypothesis that many of these are due to alterations in the position and direction of individual septal buds are should be seen against the overall background of septal pathology. Under these circumstances the pathogenetic importance of alterations of the complex movements presented by the cardiac type during the course of septal development and, to an event greater extent, possible alterations of the embryonal hematic flow are underlined.


Assuntos
Valva Aórtica/anormalidades , Defeitos dos Septos Cardíacos , Transposição dos Grandes Vasos , Defeitos dos Septos Cardíacos/patologia , Humanos , Recém-Nascido , Masculino , Miocárdio/patologia , Transposição dos Grandes Vasos/patologia
4.
Minerva Cardioangiol ; 39(6): 213-8, 1991 Jun.
Artigo em Italiano | MEDLINE | ID: mdl-1961439

RESUMO

Twenty-seven cases of autopsy showing hypoplasia of one of the ventricular cavities, prevalently the left, were selected from a series of 103 congenital cardiopathies (1979-1990). In 9 cases ventricular hypoplasia formed part of complex malformative syndromes with a well-known physiognomy: a further 18 cases showed a complete (9 cases) or incomplete (9 cases) hypoplastic heart syndrome. Subjects were prevalently female and the presence of other malformations indicating a genetic dysfunction was less evident than in other cardiopathies. The different pathogenetic hypotheses are discussed in the light of macro- and microscopic morphological factors, of which the most plausible is that involving an anomalous position or orientation of the musculo-membranous folds which give rise to the septation system of the various metamers of the cardiac tube.


Assuntos
Cardiopatias Congênitas/patologia , Ventrículos do Coração/anormalidades , Autopsia , Feminino , Humanos , Masculino
5.
Minerva Cardioangiol ; 44(12): 623-9, 1996 Dec.
Artigo em Italiano | MEDLINE | ID: mdl-9053815

RESUMO

The authors describe the autopsy finding of two fibromas within the left ventricular wall of a five-day-old newborn. Histochemistry and immunohistochemistry showed the lesion as a purely fibroblastic proliferation, with intense elastic fibers formation and secondary morphological alteration and biological damage of the pre-existing muscular fibers. The authors, on the basis of the phases of the cardiac metamers development and of myocardial tissue differentiation, exclude any relationship with disembryogenetic factors, and hence the hamartomatous origin of the lesion, despite their onset in the first months of intrauterine growth.


Assuntos
Fibroma/patologia , Neoplasias Cardíacas/patologia , Neoplasias Primárias Múltiplas/patologia , Evolução Fatal , Fibroma/congênito , Neoplasias Cardíacas/congênito , Humanos , Recém-Nascido , Masculino , Neoplasias Primárias Múltiplas/congênito
6.
Minerva Cardioangiol ; 37(12): 517-9, 1989 Dec.
Artigo em Italiano | MEDLINE | ID: mdl-2622539

RESUMO

After a 4-week wash-out period, picotamide was administered to 25 patients affected by chronic arteriopathy of the lower limbs (scale 2 according to Fontaine) at a dose of 900 mg/die for 90 days, and then at a dose of 600 mg/die for a further 90 days, in order to assess its efficacy according to the following parameters: duration of gait, residual pressure index (RPI) resting the ankles, hematochemicals, electrocardiogram. At the end of the study a statistically significant increase was observed in the duration of gait and RPI at the ankles and, of the hematochemical parameters, in an increase in fibrogenic degradation products. Adverse reactions were only observed in 3 patients and regressed spontaneously. In conclusion, picotamide was found to be efficacious in patients affected by chronic obliterating arteriopathy of the lower limbs with the possibility of reducing the dose after 3 months of therapy.


Assuntos
Anticoagulantes/administração & dosagem , Fibrinolíticos/administração & dosagem , Claudicação Intermitente/tratamento farmacológico , Perna (Membro)/irrigação sanguínea , Ácidos Ftálicos/administração & dosagem , Idoso , Avaliação de Medicamentos , Tolerância a Medicamentos , Eletrocardiografia , Teste de Esforço , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo
8.
Bronchopneumologie ; 27(6): 476-82, 1977.
Artigo em Inglês | MEDLINE | ID: mdl-608131

RESUMO

Among factors influencing long-term survival of patients how had undergone resection for carcinoma of the lung, the most important seems to be the extent of the cancer at the time of resection, determined by histopathological studies of the resected specimen.


Assuntos
Neoplasias Brônquicas/mortalidade , Neoplasias Brônquicas/cirurgia , Carcinoma/mortalidade , Adulto , Idoso , Brônquios/patologia , Neoplasias Brônquicas/patologia , Carcinoma/patologia , Carcinoma/cirurgia , Humanos , Metástase Linfática , Pessoa de Meia-Idade , Metástase Neoplásica , Pneumonectomia , Fatores de Tempo
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