Pesquisa | BVS Educação Profissional em Saúde

1.

Human fetal brain self-organizes into long-term expanding organoids.

Hendriks, Delilah; Pagliaro, Anna; Andreatta, Francesco; Ma, Ziliang; van Giessen, Joey; Massalini, Simone; López-Iglesias, Carmen; van Son, Gijs J F; DeMartino, Jeff; Damen, J Mirjam A; Zoutendijk, Iris; Staliarova, Nadzeya; Bredenoord, Annelien L; Holstege, Frank C P; Peters, Peter J; Margaritis, Thanasis; Chuva de Sousa Lopes, Susana; Wu, Wei; Clevers, Hans; Artegiani, Benedetta.

Cell ; 187(3): 712-732.e38, 2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38194967

2.

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.

Rim, Ellen Youngsoo; Clevers, Hans; Nusse, Roel.

Annu Rev Biochem ; 91: 571-598, 2022 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-35303793

3.

Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.

Hernández-López, Patricia; van Diest, Eline; Brazda, Peter; Heijhuurs, Sabine; Meringa, Angelo; Hoorens van Heyningen, Lauren; Riillo, Caterina; Schwenzel, Caroline; Zintchenko, Marina; Johanna, Inez; Nicolasen, Mara J T; Cleven, Astrid; Kluiver, Thomas A; Millen, Rosemary; Zheng, Jiali; Karaiskaki, Froso; Straetemans, Trudy; Clevers, Hans; de Bree, Remco; Stunnenberg, Hendrik G; Peng, Weng Chuan; Roodhart, Jeanine; Minguet, Susana; Sebestyén, Zsolt; Beringer, Dennis X; Kuball, Jürgen.

Nat Immunol ; 25(1): 88-101, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38012415

4.

Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr⁺ Progenitors.

Wang, Daisong; Wang, Jingqiang; Bai, Lanyue; Pan, Hong; Feng, Hua; Clevers, Hans; Zeng, Yi Arial.

Cell ; 180(6): 1198-1211.e19, 2020 03 19.

Artigo em Inglês | MEDLINE | ID: mdl-32200801

5.

Translation and Replication Dynamics of Single RNA Viruses.

Boersma, Sanne; Rabouw, Huib H; Bruurs, Lucas J M; Pavlovic, Tonja; van Vliet, Arno L W; Beumer, Joep; Clevers, Hans; van Kuppeveld, Frank J M; Tanenbaum, Marvin E.

Cell ; 183(7): 1930-1945.e23, 2020 12 23.

Artigo em Inglês | MEDLINE | ID: mdl-33188777

6.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 181(6): 1291-1306.e19, 2020 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-32407674

7.

Snake Venom Gland Organoids.

Post, Yorick; Puschhof, Jens; Beumer, Joep; Kerkkamp, Harald M; de Bakker, Merijn A G; Slagboom, Julien; de Barbanson, Buys; Wevers, Nienke R; Spijkers, Xandor M; Olivier, Thomas; Kazandjian, Taline D; Ainsworth, Stuart; Iglesias, Carmen Lopez; van de Wetering, Willine J; Heinz, Maria C; van Ineveld, Ravian L; van Kleef, Regina G D M; Begthel, Harry; Korving, Jeroen; Bar-Ephraim, Yotam E; Getreuer, Walter; Rios, Anne C; Westerink, Remco H S; Snippert, Hugo J G; van Oudenaarden, Alexander; Peters, Peter J; Vonk, Freek J; Kool, Jeroen; Richardson, Michael K; Casewell, Nicholas R; Clevers, Hans.

Cell ; 180(2): 233-247.e21, 2020 01 23.

Artigo em Inglês | MEDLINE | ID: mdl-31978343

8.

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

Gehart, Helmuth; van Es, Johan H; Hamer, Karien; Beumer, Joep; Kretzschmar, Kai; Dekkers, Johanna F; Rios, Anne; Clevers, Hans.

Cell ; 176(5): 1158-1173.e16, 2019 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-30712869

9.

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.

Wang, Hua; Xiang, Dongxi; Liu, Ben; He, Aina; Randle, Helena J; Zhang, Kelvin Xi; Dongre, Anushka; Sachs, Norman; Clark, Allison P; Tao, Luwei; Chen, Qing; Botchkarev, Vladimir V; Xie, Ying; Dai, Ning; Clevers, Hans; Li, Zhe; Livingston, David M.

Cell ; 178(1): 135-151.e19, 2019 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-31251913

10.

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time.

Crosby, Priya; Hamnett, Ryan; Putker, Marrit; Hoyle, Nathaniel P; Reed, Martin; Karam, Carolyn J; Maywood, Elizabeth S; Stangherlin, Alessandra; Chesham, Johanna E; Hayter, Edward A; Rosenbrier-Ribeiro, Lyn; Newham, Peter; Clevers, Hans; Bechtold, David A; O'Neill, John S.

Cell ; 177(4): 896-909.e20, 2019 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-31030999

11.

Defining Adult Stem Cells by Function, not by Phenotype.

Clevers, Hans; Watt, Fiona M.

Annu Rev Biochem ; 87: 1015-1027, 2018 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-29494240

12.

Cell fate specification and differentiation in the adult mammalian intestine.

Beumer, Joep; Clevers, Hans.

Nat Rev Mol Cell Biol ; 22(1): 39-53, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-32958874

13.

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Hu, Huili; Gehart, Helmuth; Artegiani, Benedetta; LÖpez-Iglesias, Carmen; Dekkers, Florijn; Basak, Onur; van Es, Johan; Chuva de Sousa Lopes, Susana M; Begthel, Harry; Korving, Jeroen; van den Born, Maaike; Zou, Chenhui; Quirk, Corrine; Chiriboga, Luis; Rice, Charles M; Ma, Stephanie; Rios, Anne; Peters, Peter J; de Jong, Ype P; Clevers, Hans.

Cell ; 175(6): 1591-1606.e19, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30500538

14.

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.

Dijkstra, Krijn K; Cattaneo, Chiara M; Weeber, Fleur; Chalabi, Myriam; van de Haar, Joris; Fanchi, Lorenzo F; Slagter, Maarten; van der Velden, Daphne L; Kaing, Sovann; Kelderman, Sander; van Rooij, Nienke; van Leerdam, Monique E; Depla, Annekatrien; Smit, Egbert F; Hartemink, Koen J; de Groot, Rosa; Wolkers, Monika C; Sachs, Norman; Snaebjornsson, Petur; Monkhorst, Kim; Haanen, John; Clevers, Hans; Schumacher, Ton N; Voest, Emile E.

Cell ; 174(6): 1586-1598.e12, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30100188

15.

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

Sachs, Norman; de Ligt, Joep; Kopper, Oded; Gogola, Ewa; Bounova, Gergana; Weeber, Fleur; Balgobind, Anjali Vanita; Wind, Karin; Gracanin, Ana; Begthel, Harry; Korving, Jeroen; van Boxtel, Ruben; Duarte, Alexandra Alves; Lelieveld, Daphne; van Hoeck, Arne; Ernst, Robert Frans; Blokzijl, Francis; Nijman, Isaac Johannes; Hoogstraat, Marlous; van de Ven, Marieke; Egan, David Anthony; Zinzalla, Vittoria; Moll, Jurgen; Boj, Sylvia Fernandez; Voest, Emile Eugene; Wessels, Lodewyk; van Diest, Paul Joannes; Rottenberg, Sven; Vries, Robert Gerhardus Jacob; Cuppen, Edwin; Clevers, Hans.

Cell ; 172(1-2): 373-386.e10, 2018 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-29224780

16.

Wnt/ß-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Nusse, Roel; Clevers, Hans.

Cell ; 169(6): 985-999, 2017 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-28575679

17.

How the Gut Feels, Smells, and Talks.

Beumer, Joep; Clevers, Hans.

Cell ; 170(1): 10-11, 2017 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-28666112

18.

Modeling Development and Disease with Organoids.

Clevers, Hans.

Cell ; 165(7): 1586-1597, 2016 Jun 16.

Artigo em Inglês | MEDLINE | ID: mdl-27315476

19.

SnapShot: Growing Organoids from Stem Cells.

Sato, Toshiro; Clevers, Hans.

Cell ; 161(7): 1700-1700.e1, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26091044

20.

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.

Dow, Lukas E; O'Rourke, Kevin P; Simon, Janelle; Tschaharganeh, Darjus F; van Es, Johan H; Clevers, Hans; Lowe, Scott W.

Cell ; 161(7): 1539-1552, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26091037

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