Detalhe da pesquisa
1.
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
; 175(1): 171-185.e25, 2018 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30146162
2.
Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model.
Bioorg Med Chem Lett
; 30(23): 127625, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096160
3.
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III.
Bioorg Med Chem Lett
; 29(3): 491-495, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553737
4.
Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II.
Bioorg Med Chem Lett
; 27(20): 4735-4740, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927793
5.
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Bioorg Med Chem Lett
; 22(1): 747-52, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22137342
6.
Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001.
J Med Chem
; 64(24): 18193-18208, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894681
7.
The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance.
J Mol Med (Berl)
; 98(8): 1161-1173, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32632752
8.
Design and Synthesis of Pyrrolidine-based Fragments That Sample Three-dimensional Molecular Space.
ACS Med Chem Lett
; 10(5): 811-815, 2019 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31098004
9.
Inhibition of nuclear factor-kappaB in T cells suppresses lung fibrosis.
Am J Respir Crit Care Med
; 176(12): 1251-60, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17901412
10.
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
J Med Chem
; 60(21): 8989-9002, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991472
11.
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches.
ACS Chem Biol
; 4(6): 473-83, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19413326
12.
Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: an inhibitor of AP-1 and NF-kappaB mediated gene expression.
Bioorg Med Chem Lett
; 12(18): 2573-7, 2002 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12182863
13.
The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies.
Bioorg Med Chem Lett
; 13(22): 4077-80, 2003 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14592511