Detalhe da pesquisa
1.
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Bioorg Med Chem Lett
; 23(1): 360-5, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23168019
2.
Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001.
J Med Chem
; 64(24): 18193-18208, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894681
3.
A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015.
Curr Med Chem
; 24(29): 3159-3184, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545370
4.
Implementation of a novel ultra fast metabolic stability analysis method using exact mass TOF-MS.
Bioanalysis
; 9(4): 359-368, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28074669
5.
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
J Med Chem
; 60(21): 8989-9002, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991472
6.
Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability.
Drug Metab Lett
; 10(2): 83-90, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26902079
7.
Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation.
Drug Metab Lett
; 10(2): 144-50, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27165340
8.
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
Mol Cancer Ther
; 14(6): 1295-305, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855786
9.
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
J Med Chem
; 58(13): 5323-33, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26083478
10.
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
J Med Chem
; 58(14): 5599-608, 2015 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26102506
11.
Proposing advancement criteria for efficient DMPK triage of new chemical entities.
Future Med Chem
; 6(2): 131-9, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24467240
12.
A proposed screening paradigm for discovery of covalent inhibitor drugs.
Drug Metab Lett
; 8(1): 19-30, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24628405
13.
Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models.
PLoS One
; 8(8): e71754, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23940785
14.
Application of 1D and 2D 1H-NMR in the structural elucidation of a N-glucuronidated metabolite and oxidized metabolites generated in microsomal incubation.
Drug Metab Lett
; 6(4): 265-74, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23607719
15.
Metabolite interference in pharmacokinetic studies.
Drug Metab Lett
; 1(4): 272-5, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356054
16.
Plasma pharmacokinetics and tissue distribution of a N-pyrrolo-[1,2-c]imidazolylphenyl sulfonamide in rats.
Drug Metab Dispos
; 30(1): 47-54, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11744611