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BACKGROUND: The interaction of our immune system with breast cancer (BC) cells prompted the investigation of tumor-infiltrating lymphocytes (TILs) and targeted, tumor antigen-specific immunotherapy. OBJECTIVES: Correlation between TILs and pathological complete response (pCR) after neoadjuvant systemic therapy (NACT). Tumor-specific antigens (TSAs) in HER2+ and triple negative BC and establishment of TSA-specific therapies within the interdisciplinary TILGen study. METHODS: Illustration of the TILGen study design. Assessment of TILs and correlation with pCR within this BC study. RESULTS: pCR was achieved in 38.4% (56/146) and associated with estrogen receptor/progesterone receptor negative (ER-/PR-) and HER2+ tumors. Lymphocytic predominant BC (LPBC) was found in 16.4% (24/146), particularly in ER-/PR- (ER-: 27.3% vs. ER+: 9.9%, PR-: 22.3% vs. PR+: 8.2%), large, and poorly differentiated BC. TILs were significantly correlated with pCR in multivariate analysis. In LPBC, pCR was achieved in 66.7%, whereas it was 32.8% in non-LPBC. CONCLUSIONS: First results confirm the influence of the human immune system on the response to NACT in HER2+ and triple negative BC. TSA-specific immunotherapy might improve the outcome in BC patients but there is an urgent need for comprehensive studies to further investigate this issue.
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Neoplasias da Mama , Biomarcadores Tumorais , Humanos , Linfócitos , Linfócitos do Interstício Tumoral , Terapia Neoadjuvante , Prognóstico , Receptor ErbB-2 , Receptores de Estrogênio , Neoplasias de Mama Triplo NegativasRESUMO
INTRODUCTION: The potential of sonography in the examination of lung tissue is extremely limited by the air-filled alveoles of the lung. Only in special circumstances like pleural adhesion lesions, atelectasis or pneumonia can lung tissue be visualized by B-mode sonography. Real-time elastography was primarily applied to detect and visualize pulmonary lesions. METHODS AND PATIENTS: 8 patients with a total of 18 histologically proven metastases of the lung were included. All pulmonary lesions were detected by computed tomography. Sonographic examination was performed with a 7.5âMHz linear transducer (Acuson Antares premium edition, Siemens, Erlangen, Germany), including B-mode and real-time elastography (RTE). The mean distance between pleura and the lesions ranged from 0 to 2.5âcm. Two lesions were located in the upper right lobe, eleven lesions in the lower right and five in the lower left lobe. RESULTS: RTE was able to detect and visualize all 18 pulmonary lesions in contrast to B-mode. The size and distance of the lesions from the pleura correlated with the CT findings. CONCLUSION: In contrast to B-mode sonography, RTE is able to detect and visualize peripheral, non-pleural adherent pulmonary lesions.
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Neoplasias da Mama/diagnóstico por imagem , Técnicas de Imagem por Elasticidade/métodos , Leiomiossarcoma/diagnóstico por imagem , Leiomiossarcoma/secundário , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/secundário , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Uterinas/diagnóstico por imagem , Idoso , Neoplasias da Mama/patologia , Técnicas de Imagem por Elasticidade/instrumentação , Estudos de Viabilidade , Feminino , Humanos , Aumento da Imagem/instrumentação , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/instrumentação , Interpretação de Imagem Assistida por Computador/métodos , Leiomiossarcoma/patologia , Pulmão/diagnóstico por imagem , Pulmão/patologia , Neoplasias Pulmonares/patologia , Pessoa de Meia-Idade , Neoplasias Ovarianas/patologia , Sensibilidade e Especificidade , Tomografia Computadorizada por Raios X , Transdutores , Carga Tumoral , Neoplasias Uterinas/patologiaRESUMO
PURPOSE: The aim of this study was to evaluate the quality standard of the nationwide breast ultrasound training program of the German Society of Ultrasound in Medicine (DEGUM) through objective parameters. MATERIALS AND METHODS: 10 quality criteria, based on the recommendations of The National Association of Statutory Health Insurance Physicians (KBV), were defined for this study. All training units of the DEGUM received a questionnaire. The questionnaires and training material were analyzed. RESULTS: All units met the required criteria pertaining to the trainer's qualification, duration per training course and the maximum number of participants per ultrasound machine. Only 1 course did not fulfill the required 50â% practical training time. The requirements to participate in the graduate course (200 self-made and documented cases) were not clearly conceived and a defined training log could be improved. CONCLUSION: DEGUM breast ultrasound training offers trainees a high level of education based on the requirements of the KBV. Despite the high quality of training, the content of course announcements could be improved and an official and structured educational index could be meaningful.
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Educação Médica Continuada/normas , Educação de Pós-Graduação em Medicina/normas , Programas Nacionais de Saúde , Sociedades Médicas , Ultrassonografia Mamária , Competência Clínica/normas , Currículo/normas , Feminino , Alemanha , Humanos , Garantia da Qualidade dos Cuidados de Saúde/normas , Indicadores de Qualidade em Assistência à Saúde/normasRESUMO
Mammography is the central diagnostic method for clinical diagnostics of breast cancer and the breast cancer screening program. In the clinical routine complementary methods, such as ultrasound, tomosynthesis and optional magnetic resonance imaging (MRI) are already combined for the diagnostic procedure. Future developments will utilize investigative procedures either as a hybrid (combination of several different imaging modalities in one instrument) or as a fusion method (the technical fusion of two or more of these methods) to implement fusion imaging into diagnostic algorithms. For screening there are reasonable hypotheses to aim for studies that individualize the diagnostic process within the screening procedure. Individual breast cancer risk prediction and individualized knowledge about sensitivity and specificity for certain diagnostic methods could be tested. The clinical implementation of these algorithms is not yet in sight.
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Neoplasias da Mama/diagnóstico , Detecção Precoce de Câncer/tendências , Previsões , Mamografia/tendências , Imagem Molecular/tendências , Imagem Multimodal/tendências , Técnica de Subtração/tendências , Algoritmos , Feminino , Humanos , Aumento da Imagem/métodosRESUMO
PURPOSE: Elastography is a new ultrasonographic method that has been examined as a diagnostic tool for breast lesions. This study was intended to create and define new elastographic criteria allowing assessment of whether breast lesions are malignant or benign. MATERIALS AND METHODS: 217 patients with a total of 245 breast lesions of unknown malignancy underwent ultrasound examination. The new eSie Touch Elasticity Imaging technology (Siemens, Erlangen, Germany) was used with a 10-MHz linear transducer (Acuson Antares). Lesions were examined using B-mode and real-time elastography (RTE). Each lesion was histologically assessed by core biopsy. Five RTE characteristics were examined: elasticity proportion (EP), different location on RTE in comparison with B-mode (MV), different contrast patterns (SOS), dorsal lesion limitation visibility and different size on RTE in comparison with B-mode. RESULTS: 54 malignant lesions (54 %) appeared inelastic, in contrast to the benign control group (34.5 %; P = 0.001). A completely elastic pattern was visible in 10 malignant (10 %) and 39 benign lesions (26.9 %). MV was identified in 23 cases, with 22 of the lesions being malignant and one benign. The SOS was negative in 89 malignant lesions (89 %) and positive in 100 benign lesions. The dorsal lesion limitation was visible on RTE without B-mode in 88 malignant lesions (88 %) and 27 benign lesions (18.6 %). The size was assessed as larger in 45 malignant lesions (45 %) and seven benign lesions (4.8 %). CONCLUSION: SOS and a larger tumor size on RTE are specific characteristics of malignant breast lesions. EP, MV and distal mass border are further helpful signs to assess the malignancy of tumors.
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Neoplasias da Mama/diagnóstico por imagem , Técnicas de Imagem por Elasticidade/métodos , Aumento da Imagem/métodos , Processamento de Imagem Assistida por Computador/métodos , Ultrassonografia Mamária/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Ductal de Mama/diagnóstico por imagem , Elasticidade , Feminino , Fibroadenoma/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Análise Multivariada , Papiloma Intraductal/diagnóstico por imagem , Estudos Prospectivos , Sensibilidade e Especificidade , Adulto JovemRESUMO
PURPOSE: Phyllodes tumors (PT) are a rare entity accounting for less than 1 % of all breast lesions. They have a malignancy rate of 25-30%. Differentiation from benign fibroadenomas is difficult using ultrasound, mammogram and MRI. The elastic characteristics of both tumors were examined using real-time elastography (RTE) to find specific patterns that make differentiation possible. MATERIALS AND METHODS: From February 2007 to May 2009, a total of 620 women were examined by RTE. Histological diagnosis was achieved using core needle biopsy. 123 of the lesions were fibroadenomas, 8 were phyllodes tumors. All patients underwent mammography and ultrasound followed by RTE. Sonography was performed by Acuson Antares, Premium Edition® (Siemens, Erlangen, Germany) with a 7 and 10 MHz transducer. RESULTS: All phyllodes tumors had a similar elastic pattern with an elastic center and inelastic outer limits, referred to as the "ring sign". It was found in 5% of all fibroadenomas. CONCLUSION: RTE provides a specific elastic pattern, which is sufficient for differentiating between a fibroadenoma and a phyllodes tumor. Therefore, the detection of the most suspicious lesion in women with the coexistence of multiple fibroadenomas and phyllodes tumors seems easier.
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Neoplasias da Mama/diagnóstico por imagem , Técnicas de Imagem por Elasticidade , Fibroadenoma/diagnóstico por imagem , Interpretação de Imagem Assistida por Computador , Tumor Filoide/diagnóstico por imagem , Ultrassonografia Mamária , Adulto , Biópsia por Agulha , Mama/patologia , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Fibroadenoma/patologia , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Tumor Filoide/patologia , Sensibilidade e EspecificidadeRESUMO
PURPOSE: The aim of this retrospective clinical study was to compare the diagnostic accuracy of the novel 50 µm FFDM (full-field digital mammography) system (DR) with an established 70 µm system (DR) in the differential diagnosis between benign and malignant clusters of microcalcification (n=50) (BI-RADS™ classification 4/5) and to assess the possible incremental value of the 50 µm pixel-pitch on specificity. MATERIAL AND METHODS: From March 2009 to September 2009, 50 patients underwent full-field digital mammography (FFDM) (detector resolution 70 µm) (Novation, Siemens, Erlangen, Germany). As there were suspicious signs of microcalcification classified with BI-RADS™ 4/5 after diagnosis and preoperative wire localization, control images were made with the new FFDM system (detector: resolution 50 µm) (Amulet, Fujifilm, Tokyo, Japan) with the same exposure parameters. The diagnosis was determined after the operation by five radiologists with different experience in digital mammography from randomly distributed mediolateral views (monitor reading) whose results were correlated with the final histology of all lesions. RESULTS: Histopathology revealed 19 benign and 31 malignant lesions in 50 patients after open biopsy. The results of the five readers showed a higher sensitivity of the new FFDM system (80.0%) in the ability to recognize malignant microcalcification in comparison to the established system (74.8%). The specificity (75.8 versus 71.6%) was slightly higher for the new system but these results were not statistically significant (p<0.001). Considering the diagnostic accuracy, the new system (detector: resolution 50 µm) was also slightly superior to the well-known system (detector: resolution 70 µm) (80.1% versus 76.4%). CONCLUSIONS: Our study has shown that the new full-field digital mammography system using the novel detector compared with the already established FFDM system with respect to the assessment of microcalcification is at least equivalent.
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Doenças Mamárias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Mamografia/instrumentação , Intensificação de Imagem Radiográfica/instrumentação , Intensificação de Imagem Radiográfica/métodos , Transdutores , Adolescente , Adulto , Idoso , Desenho de Equipamento , Análise de Falha de Equipamento , Humanos , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Adulto JovemRESUMO
PURPOSE: The article describes an experimental phantom study of a system for digital full field mammography with a new digital detector with a double plate of pure selenium. MATERIALS AND METHODS: The experiments were carried out with the new full field digital mammography system Amulet from FujiFilm. This system has a new detector (18×24 cm(2)) on the basis of highly purified amorphous selenium (a-Se) with a pixel size of 50 µm. The x-rays are converted into electric signals in the first plate which are read into the second plate with the help of an optical switch and demonstrated in the form of an image. In this way a better pixel size/volume and signal-to-noise ratio should be achieved. The object of the investigation was the Wisconsin Mammographic Random Phantom, Model 152 A (Technical Performance Mo/Mo, 28 kV, 100 mAs). Five investigators with different experiences in mammography each received three images on a monitor with different random positions of the simulated lesions in the phantom for assessment. The detection rates were compared under the same conditions with the results of two other full field digital mammography systems. RESULTS: The median detection rate for all images and investigators for the new doubled plated a-Se detector with optical switch was 98.7%. For both other systems with a-Si or and a-Se detectors the detection rate was 89.8% or 97.3%, respectively. There were no significant differences in the detection rate of the simulated breast lesions for all three systems considering the interobserver and intraobserver variation. CONCLUSION: The first phantom study for the detection of simulated breast lesions with the new full field digital mammography system Amulet demonstrates equivalent results with the other systems used in the clinical routine. The trend towards superiority of the new system has to be confirmed in further clinical studies.
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Neoplasias da Mama/diagnóstico por imagem , Mamografia/instrumentação , Intensificação de Imagem Radiográfica/instrumentação , Selênio , Transdutores , Desenho de Equipamento , Análise de Falha de Equipamento , Feminino , Humanos , Variações Dependentes do Observador , Imagens de Fantasmas , Projetos Piloto , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
Diagnostic investigations of mammary glands, which are routinely undertaken prior to a planned liver transplantation, can place high demands on the radiologist. The article describes a case of known Ehlers-Danlos syndrome, where it was essential that the radiologist was sufficiently informed over the past history, possible previously made images and typical presentation forms of microcalcification for corresponding findings from the breast diagnostics.
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Doenças Mamárias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Síndrome de Ehlers-Danlos/diagnóstico por imagem , Mamografia/métodos , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
The updated 2008 German Guideline for Early Detection of Breast Cancer provides evidence-based and consensus-based recommendations of the knowledge gained by the German Society for Surgery and the German Society of Plastic, Aesthetic, and Reconstructive Surgeons together with 29 professional societies, associations, and nonmedical organizations. The guideline is meant to assist physicians, healthy women, and patients in medical decisions with recommendations regarding the diagnostic chain in early detection of breast cancer. In addition to these recommendations, the guideline also includes descriptions of quality assurance for resources, procedures, outcomes, and evaluation using a set of quality indicators. It updates the previous version from 2003. The guideline's recommendations are presented. They are described in detail in the full publication (in German) Geburtsh Frauenh 2008; 68:251-261. The long version of the Guideline, methods report, and evidence report are available on the internet at www.awmf-leitlinien.de (reg. no. 077/001) with free access.
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Neoplasias da Mama/diagnóstico , Biópsia , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Diagnóstico Precoce , Feminino , Alemanha , Humanos , Imageamento por Ressonância Magnética , Mamografia , Programas de Rastreamento , Mastectomia Segmentar , Equipe de Assistência ao Paciente , Educação de Pacientes como Assunto , Garantia da Qualidade dos Cuidados de Saúde , Indicadores de Qualidade em Assistência à Saúde , Fatores de Risco , Ultrassonografia MamáriaRESUMO
Mammography is the most effective method for breast cancer screening available today. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. To reduce the high number of unnecessary breast biopsies, several computer-aided diagnosis (CAD) systems have been proposed in the last several years. These systems help physicians in their decision to perform a breast biopsy on a suspicious lesion seen in a mammogram or to perform a short term follow-up examination instead. We present two novel CAD approaches that both emphasize an intelligible decision process to predict breast biopsy outcomes from BI-RADS findings. An intelligible reasoning process is an important requirement for the acceptance of CAD systems by physicians. The first approach induces a global model based on decison-tree learning. The second approach is based on case-based reasoning and applies an entropic similarity measure. We have evaluated the performance of both CAD approaches on two large publicly available mammography reference databases using receiver operating characteristic (ROC) analysis, bootstrap sampling, and the ANOVA statistical significance test. Both approaches outperform the diagnosis decisions of the physicians. Hence, both systems have the potential to reduce the number of unnecessary breast biopsies in clinical practice. A comparison of the performance of the proposed decision tree and CBR approaches with a state of the art approach based on artificial neural networks (ANN) shows that the CBR approach performs slightly better than the ANN approach, which in turn results in slightly better performance than the decision-tree approach. The differences are statistically significant (p value < 0.001). On 2100 masses extracted from the DDSM database, the CRB approach for example resulted in an area under the ROC curve of A(z) = 0.89 +/- 0.01, the decision-tree approach in A(z) = 0.87 +/- 0.01, and the ANN approach in A(z) = 0.88 +/- 0.01.
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Doenças Mamárias/diagnóstico por imagem , Diagnóstico por Computador , Mamografia/métodos , Interpretação de Imagem Radiográfica Assistida por Computador , Adulto , Idoso , Idoso de 80 Anos ou mais , Algoritmos , Biópsia , Bases de Dados Factuais , Técnicas de Apoio para a Decisão , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Modelos Estatísticos , Variações Dependentes do Observador , Curva ROCRESUMO
PURPOSE: Reduction of radiation exposure at an adequate image quality by optimizing the radiation quality for a new system of full-field digital mammography using a digital detector (a-Se). MATERIALS AND METHODS: The investigations were performed using a digital mammography system Novation (Siemens, Erlangen). The system was constructed with a bimetal anode (molybdenum and tungsten) and the possibility of changing the filter (molybdenum/rhodium). The test object was the Wisconsin Mammography Random Phantom Model 152 A (Radiation Measurements Inc.) of which images were acquired using the digital technique with the tungsten anode and rhodium filter at different tube voltages (26-35 kV) and tube loads (40-100 mAs) and compared to images in the molybdan/molybdan molybdenum/molybdenum technique. To quantify the image quality, we used the detection rate of the simulated lesions in the phantom. RESULTS: Increasing the tube voltage significantly decreases the average glandular dose when using AEC (Automatic Exposure Control), i. e., constant detector dose. At the same time, the image quality decreases significantly with respect to the detection rate (26 kV, 1 mGy, 95.1 %; 35 kV, 0.7 mGy, 82.7 %). As a good compromise between the necessary diagnostic image quality and the lowest dose exposition, 28 kV and 60 mAs were selected for imaging with the tungsten/rhodium anode/filter combination. A further change to the tube load did not make sense because a decrease of 10 % resulted in a significant decrease in the detection rate while only a 2 % increase in detection rate was achieved for a 65 % increase in radiation exposure. CONCLUSION: The results of this phantom study demonstrate that the routine use of the tungsten anode in combination with a rhodium filter for full-field digital mammography with an a-Se detector in contrast to a molybdan/molybdan molybdenum/molybdenum anode/filter combination results in a reduction of the average glandular dose of up to 30 % without loss of diagnostic image quality.
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Mamografia/métodos , Intensificação de Imagem Radiográfica/métodos , Feminino , Humanos , Molibdênio , Imagens de Fantasmas , Doses de Radiação , Ródio , Sensibilidade e Especificidade , TungstênioRESUMO
PURPOSE: Evaluation of the diagnostic value of breast specimen imaging with a digital mammographic system using a detector system with changeable pixel size compared to standard mode imaging in different monitor display modes. MATERIALS AND METHODS: Using the digital mammographic system SenoScan (Fischer Imaging, Denver, USA), 50 diagnostic breast specimens with microcalcifications were visualized in both standard mode (pixel size 54 microm) and high resolution mode (pixel size 27 microm). The resulting radiographs were displayed 1:1 on a monitor. Standard mode images (pixel size 54 microm) were additionally displayed in a 2:1 mode. A total of 5 readers with different mammographic experience analyzed the type of the microcalcifications on the basis of the different display modes. The images were presented randomly. The findings were subsequently compared to the histology. RESULTS: The high resolution mode yielded slightly but not significantly better results than the standard mode on average for all 5 readers. Compared to a sensitivity of 80 % and a specificity of 72 % (PPV = 74 %, NPV = 78 %) in the standard mode, the high resolution mode provided a sensitivity of 86 % and a specificity of 74 % (PPV = 77 %, NPV = 83 %). The standard mode images on a 2:1 monitor display yielded 84 % and 74 % (PPV = 76 %, NPV = 82 %). CONCLUSION: The high resolution mode did not significantly increase the sensitivity and specificity of the microcalcification reading. A similar improvement was achieved by the 2:1 display mode, i. e. digital monitor zooming. For the clinical situation this means that there is no diagnostic advantage from using a high resolution target view with this mammographic system.
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Neoplasias da Mama/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Mamografia/métodos , Intensificação de Imagem Radiográfica/métodos , Humanos , Masculino , Imagens de Fantasmas , Doses de RadiaçãoRESUMO
Introduction The placement of intramammary marker clips has proven to be helpful for tumor localization in patients undergoing neoadjuvant chemotherapy and breast-conserving surgery. The purpose of our study was to investigate the feasibility of using a clip marker system for breast cancer localization and its influence on the imaging assessment of treatment responses after neoadjuvant chemotherapy. Patients and Methods Between March and June 2015, a total of 25 patients (n = 25), with a suspicion of invasive breast cancer with diameters of at least 2 cm (cT2), underwent preoperative sonographically guided core needle biopsy using a single-use breast biopsy system (HistoCore™) and intramammary clip marking using a directly adapted clip system based on the established O-Twist Marker™, before their scheduled preoperative neoadjuvant chemotherapy. Localization of the intramammary marker clip was controlled by sonography and digital breast tomosynthesis. Results Sonography detected no dislocation of intrammammary marker clips in 20 of 25 patients (80â%), while digital breast tomosynthesis showed accurate placement without dislocation in 24 patients (96â%) (p < 0.05). There was no evidence of significant clip migration during preoperative follow-up imaging after neoadjuvant chemotherapy. No complication related to the clip marking was noted and there was no difficulty in evaluating the treatment response to neoadjuvant chemotherapy. Among the breast-conserving surgeries performed, no cases were identified in which intraoperative loss of the marker clip had occurred. Conclusion Our study underscores the importance of intramammary marking clip systems before neoadjuvant chemotherapy. Placement of marker clips is advised to facilitate accurate tumor bed localization. With regard to digital breast tomosynthesis, its development continues to improve the quality of diagnostics and the therapy of breast cancer particularly for small breast cancer tumors or in neoadjuvant chemotherapy setting.
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PURPOSE: To compare the sensitivity of conventional two-dimensional (2D) projection imaging with tomosynthesis with respect to the detectability of mammographic phantom lesions. MATERIALS AND METHODS: Using a breast tomosynthesis prototype based on a commercial FFDM system (Siemens MAMMOMAT Novation), but modified for a wide angle tube motion and equipped with a fast read-out amorphous selenium detector, we acquired standard 2D images and tomosynthesis series of projection views. We used the Wisconsin mammographic random phantom, model RMI 152A. The anode filter combinations Mo/Mo and W/Rh at two different doses were used as typical radiographic techniques. Slice images through the phantom parallel to the detector were reconstructed with a distance of 1 mm employing a filtered back-projection algorithm. The image data sets were read by five radiologists and evaluated with respect to the detectability of the phantom details. RESULTS: For all studied radiographic techniques, the detection rate in the tomosynthesis mode was 100 %, i. e. 75 true positive findings out of 75 possible hits. In contrast, the conventional projection mode yielded a detection rate between 80 and 93 % (corresponding to 60 and 70 detected details) depending on the dose and X-ray spectrum. CONCLUSION: Tomosynthesis has the potential to increase the sensitivity of digital mammography. Overlapping structures from out-of-plane tissue can be removed in the tomosynthesis reconstruction process, thereby enhancing the diagnostic accuracy.
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Imageamento Tridimensional , Mamografia/métodos , Imagens de Fantasmas , Intensificação de Imagem Radiográfica , Interpretação de Imagem Radiográfica Assistida por Computador , Algoritmos , Ensaios Clínicos como Assunto , Computadores , Humanos , Doses de Radiação , Selênio , Sensibilidade e EspecificidadeRESUMO
Introduction: Stereotactically-guided core needle biopsies (CNB) of breast tumours allow histological examination of the tumour without surgery. Touch imprint cytology (TIC) of CNB promises to be useful in providing same-day diagnosis for counselling purposes and for planning future surgery. Having addressed the issue of accuracy of immediate microscopic evaluation of TIC, we wanted to re-examine the usefulness of this procedure in light of the present health care climate of cost containment by incorporating the surgical 15-year follow-up data and outcome. Patients and Methods: From January until December 1996 we performed TIC in core needle biopsies of 173 breast tumours in 169 patients, consisting of 122 malignant and 51 benign tumours. Histology of core needle biopsies was proven by surgical histology in all malignant and in 5 benign tumours. Surgical breast biopsy was not performed in 46 patients with 46 benign lesions, as the histological result from the core needle biopsy and the result of the TIC were in agreement with the suspected diagnosis from the complementary breast diagnostics. A 15-year follow-up of these patients followed in 2013 and follow-up data was collected from 40 women. Results: In the 15-year follow-up of the 40 benign lesions primarily confirmed using CNB and TIC, a diagnostic sensitivity, specificity, positive and negative predictive value and accuracy of 100â% was found. Conclusion: TIC and stereotactically guided CNB showed excellent long-term follow-up in patients with benign breast lesions. The use of TIC to complement CNB can therefore provide immediate cytological diagnosis of breast lesions.
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BACKGROUND: To improve breast cancer treatment, the evaluation of predictive factors is in the focus of clinical research. Significant discrepancies between the clinical assessment of response to neoadjuvant chemotherapy (NACT) and the pathological assessment of response from post-therapy surgical specimens have been demonstrated. We focused on comparing the value of various diagnostic methods used in medical routine. PATIENTS AND METHODS: A clinical evaluation of the primary tumour and regional lymph nodes before and after NACT was performed in 139 patients by physical examination, sonography and mammography. RESULTS: Mammography and physical examination correlated best with pathological findings in the measurement of the tumour, whereas sonography was the most accurate predictor of the status for axillary lymph nodes. CONCLUSION: Mammography and physical examination are the best non-invasive predictors of the real size of the primary breast cancer, whereas sonography correlates better with the proven status of axillary lymph nodes.
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Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/tratamento farmacológico , Adulto , Idoso , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Ciclofosfamida/administração & dosagem , Epirubicina/administração & dosagem , Feminino , Humanos , Mamografia , Pessoa de Meia-Idade , Terapia Neoadjuvante , Estadiamento de Neoplasias , Paclitaxel/administração & dosagem , Exame Físico , Estudos Prospectivos , Ultrassonografia MamáriaRESUMO
PURPOSE: The NMR-MOUSE is an open and mobile sensor for measuring NMR relaxation parameters in organic matters. T1-measurements of the subcutaneous fatty tissue and the skin are reported. MATERIAL AND METHOD: For the first time, the NMR-MOUSE was employed to measure the signal recovery following saturation of the skin and the subcutaneous fatty tissue of three patients, before and after administering a contrast agent. RESULTS: Despite a low signal-to-noise ratio, changes in the relaxation behaviour of the skin could be detected. Malignant tissue exhibits faster signal recovery than scar tissue and healthy tissue, which only show a small difference. CONCLUSIONS: Changes in the relaxation behavior can be monitored with the NMR-MOUSE. Before the clinical use of the NMR-MOUSE, sensitivity, sensor mounting device, and sensor tuning must be improved. Further investigations need to be performed on a statistically relevant number of patients.
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Tecido Adiposo/química , Tecido Adiposo/patologia , Neoplasias da Mama/diagnóstico , Análise de Falha de Equipamento , Espectroscopia de Ressonância Magnética/métodos , Pele/química , Pele/patologia , Adulto , Idoso , Desenho de Equipamento , Estudos de Viabilidade , Feminino , Humanos , TransdutoresRESUMO
PURPOSE: To determine the diagnostic accuracy of microcalcifications and focal lesions in a retrospective clinical-histological study using high-resolution digital phosphor storage plates (hard copy) and full-field digital mammography (hard copy). MATERIALS AND METHODS: From May 2003 to September 2003, 102 patients underwent digital storage plate mammography (CR), using a mammography unit (Mammomat 3000 N, Siemens) in combination with a high resolution (9 lp/mm) digital storage phosphor plate system (pixel size 50 microm) (Fuji/Siemens). After diagnosis and preoperative wire localization, full-field digital mammography (CCD) (DR) was performed with the same exposure parameters. The full-field digital mammography used a CCD-detector (SenoScan) (Fisher Imaging) with a resolution of 10 Ip/mm and a pixel size of 50 microm. Five investigators determined the diagnosis (BI-RADS I - V) retrospectively after the operation from randomly distributed mediolateral views (hard copy reading). These results were correlated with the final histology. RESULTS: The diagnostic accuracy of digital storage plate mammography (CR) and full-field digital mammography (CCD) (DR) was 73 % and 71 % for all findings (n = 102), 73 % and 71 % for microcalcifications (n = 51), and 72 % and 70 % for focal lesions (n = 51). The overall results showed no difference. CONCLUSION: Our findings indicate the equivalence of high-resolution digital phosphor storage plate mammography (CR) and full-field digital mammography (CCD) (DR).