Detalles de la búsqueda
1.
Generation of bispecific antibodies using chemical conjugation methods.
Drug Discov Today Technol;
40: 13-24, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34916015
2.
Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site.
Int J Mol Sci;
21(18)2020 Sep 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32961794
3.
Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads.
Bioorg Med Chem Lett;
28(23-24): 3617-3621, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30389292
4.
Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Cysteine Insertion.
Mol Pharm;
14(5): 1501-1516, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28245132
5.
A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments.
Biomacromolecules;
17(5): 1818-33, 2016 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27007881
6.
CD19 and CD32b differentially regulate human B cell responsiveness.
J Immunol;
192(4): 1480-90, 2014 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24442430
7.
Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody.
Bioconjug Chem;
26(10): 2085-96, 2015 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26340339
8.
Development of a Trispecific Antibody Designed to Simultaneously and Efficiently Target Three Different Antigens on Tumor Cells.
Mol Pharm;
12(9): 3490-501, 2015 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26176328
9.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Clin Cancer Res;
29(6): 1086-1101, 2023 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36355054
10.
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.
Mol Cancer Ther;
20(3): 541-552, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33653945
11.
Preclinical Characterization of an Antibody-Drug Conjugate Targeting CS-1 and the Identification of Uncharacterized Populations of CS-1-Positive Cells.
Mol Cancer Ther;
19(8): 1649-1659, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32404408
12.
Characterization of Disulfide Bond Rebridged Fab-Drug Conjugates Prepared Using a Dual Maleimide Pyrrolobenzodiazepine Cytotoxic Payload.
ChemMedChem;
14(12): 1185-1195, 2019 06 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30980702
13.
Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.
Pharmaceutics;
11(10)2019 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31640157
14.
Fab-Arm Exchange Combined with Selective Protein A Purification Results in a Platform for Rapid Preparation of Monovalent Bispecific Antibodies Directly from Culture Media.
Pharmaceutics;
12(1)2019 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31861347
15.
Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
MAbs;
11(3): 500-515, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30835621
16.
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering.
Biophys J;
94(5): 1766-72, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17993503
17.
The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1.
J Mol Biol;
367(2): 310-8, 2007 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17275839
18.
Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs.
Data Brief;
21: 2208-2220, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30533469
19.
SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads.
Clin Cancer Res;
24(24): 6570-6582, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30131388
20.
Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
Mol Cancer Ther;
17(10): 2176-2186, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30065100