Detalles de la búsqueda
1.
Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake.
Drug Metab Dispos;
52(6): 548-554, 2024 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38604729
2.
New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry.
Anal Chem;
95(8): 4086-4094, 2023 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36791153
3.
Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration.
Drug Metab Dispos;
51(10): 1284-1294, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37349116
4.
Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic.
Drug Metab Dispos;
50(7): 1042-1052, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35545255
5.
Application of empirical scalars to enable early prediction of human hepatic clearance using IVIVE in drug discovery: an evaluation of 173 drugs.
Drug Metab Dispos;
2022 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636770
6.
Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial.
J Allergy Clin Immunol;
148(3): 783-789, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33744327
7.
Strategies to Mitigate the Bioactivation of Aryl Amines.
Chem Res Toxicol;
33(7): 1950-1959, 2020 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32508087
8.
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.
Drug Metab Dispos;
47(10): 1206-1221, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31439574
9.
Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.
Drug Metab Dispos;
47(10): 1122-1135, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31266753
10.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett;
29(12): 1522-1531, 2019 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30981576
11.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.
Drug Metab Dispos;
46(9): 1285-1303, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-29959133
12.
Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species.
Anal Biochem;
556: 85-90, 2018 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29959909
13.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos;
45(10): 1049-1059, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28646080
14.
Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.
Drug Metab Dispos;
44(6): 821-32, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27026679
15.
Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.
Pharm Res;
33(5): 1204-19, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26869174
16.
Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio.
J Pharm Sci;
113(4): 1094-1112, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38220087
17.
Critical review of preclinical approaches to investigate cytochrome p450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: a white paper.
Drug Metab Dispos;
41(9): 1598-609, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23792813
18.
Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors.
Bioorg Med Chem Lett;
23(21): 5923-30, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24042009
19.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett;
23(12): 3592-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23642482
20.
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Bioorg Med Chem Lett;
23(17): 5014-21, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23870430