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1.

The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest.

Ullah, Imran; Sharma, Raman; Mete, Antonio; Biagini, Giancarlo A; Wetzel, Dawn M; Horrocks, Paul D.

J Antimicrob Chemother; 75(2): 362-370, 2020 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-31665424

2.

The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD.

Mete, Antonio; Bowers, Keith; Bull, Richard J; Coope, Helen; Donald, David K; Escott, Katherine J; Ford, Rhonan; Grime, Ken; Mather, Andrew; Ray, Nicholas C; Russell, Vince.

Bioorg Med Chem Lett; 23(23): 6248-53, 2013 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-24144851

3.

Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap.

Mete, Antonio; Andrews, Glen; Bernstein, Mike; Connolly, Stephen; Hartopp, Paul; Jackson, Clive G; Lewis, Richard; Martin, Iain; Murray, David; Riley, Rob; Robinson, David H; Smith, Gill M; Wells, Edward; Withnall, W John.

Bioorg Med Chem Lett; 21(10): 3128-33, 2011 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-21450464

4.

The discovery of AZD9164, a novel muscarinic M3 antagonist.

Mete, Antonio; Bowers, Keith; Chevalier, Eric; Donald, David K; Edwards, Helen; Escott, Katherine J; Ford, Rhonan; Grime, Ken; Millichip, Ian; Teobald, Barry; Russell, Vince.

Bioorg Med Chem Lett; 21(24): 7440-6, 2011 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-22047691

5.

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Cheshire, David R; Åberg, Anders; Andersson, Gunilla M K; Andrews, Glen; Beaton, Haydn G; Birkinshaw, Timothy N; Boughton-Smith, Nigel; Connolly, Stephen; Cook, Tony R; Cooper, Anne; Cooper, Sally L; Cox, David; Dixon, John; Gensmantel, Nigel; Hamley, Peter J; Harrison, Richard; Hartopp, Paul; Käck, Helena; Leeson, Paul D; Luker, Timothy; Mete, Antonio; Millichip, Ian; Nicholls, David J; Pimm, Austen D; St-Gallay, Steve A; Wallace, Alan V.

Bioorg Med Chem Lett; 21(8): 2468-71, 2011 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-21398123

6.

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin, Elsa D; Arvai, Andrew S; Rosenfeld, Robin J; Kroeger, Matt D; Crane, Brian R; Andersson, Gunilla; Andrews, Glen; Hamley, Peter J; Mallinder, Philip R; Nicholls, David J; St-Gallay, Stephen A; Tinker, Alan C; Gensmantel, Nigel P; Mete, Antonio; Cheshire, David R; Connolly, Stephen; Stuehr, Dennis J; Aberg, Anders; Wallace, Alan V; Tainer, John A; Getzoff, Elizabeth D.

Nat Chem Biol; 4(11): 700-7, 2008 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-18849972

7.

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

Kindon, Nicholas; Andrews, Glen; Baxter, Andrew; Cheshire, David; Hemsley, Paul; Johnson, Timothy; Liu, Yu-Zhen; McGinnity, Dermot; McHale, Mark; Mete, Antonio; Reuberson, James; Roberts, Bryan; Steele, John; Teobald, Barry; Unitt, John; Vaughan, Deborah; Walters, Iain; Stocks, Michael J.

ACS Med Chem Lett; 8(9): 981-986, 2017 Sep 14.

Artículo en Inglés | MEDLINE | ID: mdl-28947948

8.

Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.

Connolly, Stephen; Bennion, Colin; Botterell, Sarah; Croshaw, Pamela J; Hallam, Catherine; Hardy, Kim; Hartopp, Paul; Jackson, Clive G; King, Sarah J; Lawrence, Louise; Mete, Antonio; Murray, David; Robinson, David H; Smith, Gillian M; Stein, Linda; Walters, Iain; Wells, Edward; Withnall, W John.

J Med Chem; 45(6): 1348-62, 2002 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-11882004

9.

Inhibitors of the NOS enzymes: a patent review.

Mete, Antonio; Connolly, Stephen.

IDrugs; 6(1): 57-65, 2003 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-12789622

10.

Cathepsin C inhibitors: property optimization and identification of a clinical candidate.

Furber, Mark; Tiden, Anna-Karin; Gardiner, Philip; Mete, Antonio; Ford, Rhonan; Millichip, Ian; Stein, Linda; Mather, Andrew; Kinchin, Elizabeth; Luckhurst, Christopher; Barber, Simon; Cage, Peter; Sanganee, Hitesh; Austin, Rupert; Chohan, Kamaldeep; Beri, Raj; Thong, Bob; Wallace, Alan; Oreffo, Victor; Hutchinson, Ray; Harper, Steve; Debreczeni, Judit; Breed, Jason; Wissler, Lisa; Edman, Karl.

J Med Chem; 57(6): 2357-67, 2014 Mar 27.

Artículo en Inglés | MEDLINE | ID: mdl-24592859

11.

Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.

Walters, Iain; Bennion, Colin; Connolly, Stephen; Croshaw, Pamela J; Hardy, Kim; Hartopp, Paul; Jackson, Clive G; King, Sarah J; Lawrence, Louise; Mete, Antonio; Murray, David; Robinson, David H; Stein, Linda; Wells, Edward; John Withnall, W.

Bioorg Med Chem Lett; 14(14): 3645-9, 2004 Jul 16.

Artículo en Inglés | MEDLINE | ID: mdl-15203135

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