The reproducibility of clinical OSA subtypes: a population-based longitudinal study.

PURPOSE: The identification of subgroups of obstructive sleep apnea (OSA) is critical to understand disease outcome and treatment response and ultimately develop optimal care strategies customized for each subgroup. In this sense, we aimed to perform a cluster analysis to identify subgroups of individuals with OSA based on clinical parameters in the Epidemiological Sleep Study of São Paulo city (EPISONO). We aimed to analyze whether or not subgroups remain after 8 years, since there is not any evidence showing if these subtypes of clinical presentation of OSA in the same population can change overtime. METHODS: We used data derived from EPISONO cohort, which was followed over 8 years after baseline evaluation. All individuals underwent polysomnography, answered questionnaires, and had their blood collected for biochemical examinations. OSA was defined according to AHI ≥ 15 events/h. Cluster analysis was performed using latent class analysis (LCA). RESULTS: Of the 1042 individuals in the EPISONO cohort, 68% agreed to participate in the follow-up study (n = 712), and 704 were included in the analysis. We were able to replicate the OSA 3-cluster solution observed in previous studies: disturbed sleep, minimally symptomatic and excessively sleepy in both baseline (36%, 45% and 19%, respectively) and follow-up studies (42%, 43%, and 15%, respectively). The optimal cluster solution for our sample based on Bayesian information criterion (BIC) was 2 cluster for baseline (disturbed sleep and excessively sleepy) and 3 clusters for follow-up (disturbed sleep, minimally symptomatic, and excessively sleepy). A total of 45% of the participants migrated clusters between the two evaluations (and the factor associated with this was a greater delta-AHI (B = - 0.033, df = 1, p = 0.003). CONCLUSIONS: The results replicate and confirm previously identified clinical clusters in OSA which remain in the longitudinal analysis, with some percentage of migration between clusters.

Do circadian preferences influence the sleep patterns of night shift drivers?

OBJECTIVE: The objective of this study was to analyze the effect of individual circadian preferences of drivers with fixed night work schedules on sleep patterns. SUBJECTS AND METHODS: A total of 123 professional drivers, 32 indifferent preference drivers and 91 morning preference drivers of an intermunicipality and interstate bus transportation company were evaluated. All drivers underwent polysomnographic recordings after their shifts. Furthermore, they filled out a questionnaire that contained sociodemographic and health questions. The Horne and Östberg questionnaire was used to assess the subjects' morningness-eveningness preference. RESULTS: The mean age was 42.54 ± 6.98 years and 82 (66.66%) of the drivers had worked for ≥15 years. A significant effect on rapid eye movement (REM) was observed in the morning preference drivers. They showed an increased sleep latency and an REM sleep percentage of 5% of the total REM time. This reveals a significant effect on sleep architecture associated with work time. CONCLUSION: The drivers reported that morning preference had a significant effect on their sleep pattern indicating less REM sleep and longer REM sleep latency in the morning preference group. Thus, it is important to evaluate interactions between individual aspects of health and other parameters, such as sleep quality and work organizational factors, to promote night shift workers' health and well-being.

Effects of social distancing caused by the COVID-19 pandemic on physical activity level, sitting time, and binge eating: a comparison between overweight/obese and normal-weight adults.

Purpose: To compare changes in physical activity level (PAL), sitting time (ST), and binge eating disorder (BED) in overweight/obese adults vs. those normal weight during social distancing caused by the COVID-19 pandemic. Methods: A cross-sectional and retrospective study was carried out with adults of both sexes, aged 18-60 years, which assessed, through an online form, the PAL, ST, and BED pre (PSD) and during social distancing (DSD) caused by the COVID-19 pandemic. The PAL and ST were assessed by the short version of the International Physical Activity Questionnaire and the assessment of BED by the Binge Eating Scale. Results: 323 responses were included in the analysis (194 normal weight and 129 overweight/obese). There was a decrease in PAL and an increase in the prevalence of BED in both groups; nevertheless, the overweight/obese group had a 62% chance of presenting lower PALs than normal-weight individuals (OR = 1.62; 95% CI 1.03-2.55) and showed a lower total weekly physical activity time during the pandemic (adjusted p = 0.05). In addition, overweight individuals were more likely to binge eat before (OR = 4.21; 95% CI 2.10-8.45) and during the pandemic (OR = 4.24; 95% CI 2.54-7.06) and showed a higher prevalence during social distancing. Conclusion: The social distancing caused by the COVID-19 pandemic changed exercise behaviors and increased the prevalence of binge eating in the general population. However, overweight/obese participants engaged in less total weekly physical activity and showed a higher prevalence of binge eating before and during social distancing. Level of evidence: Level III; analytical observational cohort study.

The treatment of mild OSA with CPAP or mandibular advancement device and the effect on blood pressure and endothelial function after one year of treatment.

STUDY OBJECTIVES: To evaluate and compare the effects of continuous positive airway pressure (CPAP), use of a mandibular advancement device (MAD), and no treatment on 24-hour ambulatory blood pressure monitoring and peripheral arterial tonometry at 6 and 12 months follow-up in individuals with mild obstructive sleep apnea (OSA), and in a subgroup who had an apnea-hypopnea index of < 5 events/h and adherence of ≥ 4 hours per night (effective-treatment subgroups). METHODS: The inclusion criteria were individuals with mild obstructive sleep apnea, any sex, age between 18 and 65 years, and a body mass index of ≤ 35 kg/m². Patients were randomized into CPAP, MAD, and no-treatment groups. The evaluations included physical examination, full polysomnography, 24-hour ambulatory blood pressure monitoring, and peripheral arterial tonometry at baseline and after 6 and 12 months. A generalized linear mixed model was used for comparisons. RESULTS: The CPAP and MAD groups had lower apnea-hypopnea indexes than the control group at 6 and 12 months, and the CPAP group had higher blood oxygen levels (SpO2) than the MAD group. The MAD group had more hours of treatment per night and better adaptation to treatment than the CPAP group (MAD: 5.7 ± 2.7 h/night; CPAP: 3.8 ± 3.4 h/night; MAD: 16% did not adapt; CPAP: 42% did not adapt). No differences were found in the total sample and effective treatment in relation to peripheral arterial tonometry or 24-hour ambulatory blood pressure monitoring outcomes. CONCLUSIONS: Treatment of mild obstructive sleep apnea with CPAP or MAD did not improve blood pressure or endothelial function after 1 year, even in patients with effective treatment. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov; Name: Continuous Positive Airway Pressure and Oral Appliances Treatments in Mild Obstructive Sleep Apnea; URL: https://clinicaltrials.gov/ct2/show/NCT01461486; Identifier: NCT01461486.

Adipocytokine and appetite-regulating hormone response to weight loss in adolescents with obesity: Impact of weight loss magnitude.

OBJECTIVE: The aim of this study was to investigate the association between the magnitude of weight loss (WL) and serum concentrations of the main adipocytokines and appetite-regulating hormones in adolescents with obesity. METHODS: After completion of informed consent,108 adolescents with obesity (14-19 y of age; postpubertal) were submitted to clinical, nutritional, psychological, physical exercise, and physiotherapy support for 1 y. Body composition (BC) and plasma levels of neuropeptides (neuropeptide Y [NPY], agouti-related peptide [AgRP], and α-melanocyte-stimulating hormone [α-MSH]) and leptin were measured at baseline and post-intervention. RESULTS: After therapy, adolescents who lost <10% body weight and <10% body weight (were compared. Both groups presented improvements in BC and reduced leptin. The Δα-MSH, Δα-MSH/AgRP ratio, and Δα-MSH/NPY ratio were lower and AgRP and NPY variations were higher in the low weight loss group. The leptin concentration was close to normal in the high weight loss only. The ΔWeight, Δα-MSH and Δleptin were associated with body fat loss by multiple linear regressions for all samples. CONCLUSION: Weight loss >10% seems to reverse obesity-induced hyperleptinemia while stabilizing the neuropeptides that control appetite in adolescents with obesity. We were able to produce a prognostic mathematical model to predict body fat loss using weight, leptin, and α-MSH variations.

Prevalence of and risk factors for obstructive sleep apnea syndrome in Brazilian railroad workers.

OBJECTIVE: This study evaluated the prevalence of, and the risk factors for, obstructive sleep apnea syndrome (OSAS) among Brazilian railroad workers. METHODS: Male railroad workers (745) from a railway company in Brazil were analyzed after responding to questionnaires about their demographics, sleep habits, excessive daytime sleepiness (Epworth), and the likelihood of having apnea (Berlin). We also performed polysomnography and measured anthropometric data for all of the railroad workers. RESULTS: The results showed that 261 (35.03%) of the railroad workers presented with OSAS. These railroad workers were older (OSAS: 38.53±10.08 versus non-OSAS: 33.99±8.92 years), more obese according to body mass index (27.70±4.38 versus 26.22±3.92 kg/m(2)), and employed for a longer period of time (14.32±9.13 years) compared with those without OSAS (10.96±7.66 years). Among those with OSAS, 9.5% were smokers and 54.7% reported alcohol use. The associated risk factors were age (OR=2.51, 95% CI=1.76-3.57), BMI (OR=1.56, 95% CI=1.04-2.34), alcohol use (OR=1.28, 95% CI=0.90-1.81), and a high chance of having sleep apnea, as assessed by the Berlin questionnaire (OR=2.19, 95% CI=1.49-3.21). CONCLUSION: The prevalence of OSAS in Brazilian railroad workers was higher than that observed in the general population but similar to that found in the population of the city of São Paulo, Brazil. These results suggest that age, BMI, a high risk of developing apnea through subjective self-reporting (Berlin), and alcohol use are associated with a higher risk of developing OSAS. These data reinforce the need to be more attentive to this population because they have a higher propensity for accidents.

Maquinistas ferroviários: trabalho em turnos e repercussões na saúde / Train drivers: shiftwork and health impacts

Objetivo descrever o impacto do trabalho em turnos na saúde, no sono e na qualidade de vida de maquinistas ferroviários. Métodos foram avaliados 611 maquinistas (escalas de trabalho 4 x 1 e 6 x 2), por meio de polissonografia, Índice da Qualidade do Sono de Pittsburgh, Índice de Gravidade de Insônia, Questionário de Qualidade de Vida SF-36, Questionário de Horne e Östberg, Capacidade de Trabalho e Escala de Sonolência de Epworth. Resultados os maquinistas apresentaram idade média de 36,6 ± 15,1 anos, 22% apresentaram obesidade e 38,1% risco para doenças cardiovasculares. Em relação ao sono, 64,2% dos maquinistas relataram qualidade ruim de sono, 11,6% apresentaram distúrbios do sono e 29,3% sonolência excessiva. Os resultados da polissonografia mostraram que 36,1% deles apresentaram apneia do sono e 47,2% demonstraram eficiência do sono reduzida. Além disso, os maquinistas apresentaram baixos índices de qualidade de vida, especialmente os da escala 4 x 1. Conclusão é possível afirmar, na população estudada, que a exposição ao trabalho em turnos, a rotatividade inversa, pouco tempo dispensado às folgas e horas extras de trabalho estão associados a danos ao bem-estar, saúde, sociabilização e ao sono de qualidade desses trabalhadores e que provavelmente os fatores relacionados aos turnos de trabalho contribuem para esses danos. .

Objective to describe the impact of shiftwork on the health, sleep and quality of life of railway drivers. Methods six hundred eleven railway drivers (schedule 4x1 and 6x2) were evaluated by polysomnography, Pittsburgh Sleep Quality Index, Insomnia Severity Index, Work Capacity Index, Quality of Life questionnaire (SF-36), Morningness-eveningness questionnaire (MEQ), and Epworth Sleepiness Scale. 
Results railway drivers assessed were 36.6 ± 15.1 years of age, 22% were obese, and 38.1% presented risks for cardiovascular disease. Poor sleep quality 64.2%, 11.6% had sleep disorders and 29.3% excessive sleepiness. The polysomnography results showed that 36.1% of them presented sleep apnea and 47.2% had significant reduction in sleep efficiency. The railway drivers showed low levels of quality of life, especially those working under the 4x1 schedule. Conclusion it is possible to assert that exposure to shiftwork, reverse rotation schedule, few days off, and working overtime are associated with impairment to well-being, health, sociability and workers’ sleep quality, and the factors related to shiftwork probably contribute to these findings. .