[Clinical research of isatis root eyedrops on the acute bacterial conjunctivitis].

OBJECTIVE: To evaluate the efficacy and safety of isatis root eyedrops on the acute bacterial conjunctivitis. METHODS: A randomized, double-blind and parallel study was conducted on 200 cases. Isatis root eyedrops and Hailun eyedrops (levofloxacin eyedrops), six times each day, were administered in test and control groups respectively. All patients have been observed for 7 days. The clinical effectiveness and reaction to drug after administration were assessed as the observation indexes. RESULTS: The efficacy rates in test and control group were 90% and 93%, repectively, the difference between the two groups had no statistic significance (P > 0.05). There have been two cases with side effects among the test and control groups respectively. CONCLUSION: Isatis root eyedrops have an excellent efficacy and safety on the acute bacterial conjunctivitis.

[Clinical study of diabetic retinopathy treated by compound danshen dripping pills].

OBJECTIVE: To observe the therapeutic effect of compound danshen dripping pills in visual function recovery of diabetic retinopathy. METHODS: 42 patients(78 eyes) with diabetic retinopathy of I-III phase were divided into two groups in random. 43 eyes were treated with compound danshen dripping pills and the other 35 eyes with vitamin BI and Luding C for three months. The visual acuity, fundus, visual field, fundus fluorescein angiography and visual electro-physiology were observed. RESULTS: The visual acuity in treated group were significantly improved after treatment and had significant difference with those in control group (P < 0.05). The number of micro-hemorrage, microaneurysm and the mean defect (MD) of visual field in treated group decreased obviously after treatment and had significant difference with that in control group (P < 0.05). The latent period of P100 wave and a, b wave in treated group were shorter than control group, and the wave amplitude were higher than that in control group. CONCLUSION: The compound danshen dripping pills can improve the visual acuity, control the micro-hemorrage and microaneurysm of fundus and have the effect in visual function recovery of diabetic retinopathy.

Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium.

AIM: To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia. METHODS: Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD(31) and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined. RESULTS: There was a large number of CD(31) ((+))LYVE-1((-)) blood vessels but only a few CD(31) ((+))LYVE-1((+)) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated closely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values <0.01). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia. CONCLUSION: There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.