Detalles de la búsqueda
1.
The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite.
Drug Metab Dispos;
52(7): 690-702, 2024 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38719744
2.
Employing zero-inflated beta distribution in an exposure-response analysis of TYK2/JAK1 inhibitor brepocitinib in patients with plaque psoriasis.
J Pharmacokinet Pharmacodyn;
51(3): 265-277, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38431923
3.
A phase 2a, randomized, double-blind, placebo-controlled, three-arm, parallel-group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF-06835919 in patients with non-alcoholic fatty liver disease and type 2 diabetes.
Diabetes Obes Metab;
25(4): 992-1001, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36515213
4.
A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a 14 C-microdose approach.
Br J Clin Pharmacol;
89(10): 3056-3066, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37183779
5.
An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder.
J Clin Psychopharmacol;
39(1): 20-27, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30531477
6.
Minimization of CYP2D6 Polymorphic Differences and Improved Bioavailability via Transdermal Administration: Latrepirdine Example.
Pharm Res;
33(8): 1873-80, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27072954
7.
Study of the ketohexokinase inhibitor PF-06835919 as a clinical cytochrome P450 3A inducer: Integrated use of oral midazolam and liquid biopsy.
Clin Transl Sci;
17(1): e13644, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38108609
8.
Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design.
J Cachexia Sarcopenia Muscle;
15(3): 1054-1061, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38500292
9.
Efficacy and Safety of the TYK2/JAK1 Inhibitor Brepocitinib for Active Psoriatic Arthritis: A Phase IIb Randomized Controlled Trial.
Arthritis Rheumatol;
75(8): 1370-1380, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37194394
10.
Combining patient-level and summary-level data for Alzheimer's disease modeling and simulation: a ß regression meta-analysis.
J Pharmacokinet Pharmacodyn;
39(5): 479-98, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22821139
11.
Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients.
Clin Pharmacol Drug Dev;
11(12): 1447-1456, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36045513
12.
TYK2/JAK1 Inhibitor PF-06700841 in Patients with Plaque Psoriasis: Phase IIa, Randomized, Double-Blind, Placebo-Controlled Trial.
J Invest Dermatol;
140(12): 2359-2370.e5, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32311398
13.
Pharmacokinetic and Pharmacodynamic Effects of a γ-Secretase Modulator, PF-06648671, on CSF Amyloid-ß Peptides in Randomized Phase I Studies.
Clin Pharmacol Ther;
107(1): 211-220, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31314925
14.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects.
J Alzheimers Dis;
71(2): 581-595, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31424395
15.
Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.
Br J Pharmacol;
175(4): 708-725, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29214652
16.
Diminishing the risk of nonrelapse mortality in hematopoietic stem cell transplantation: Prediction of exposure to the cyclophosphamide metabolite carboxyethylphosphoramide mustard.
Clin Pharmacol Ther;
76(3): 270-80, 2004 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-15371987
17.
A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression.
Am J Psychiatry;
165(5): 617-20, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18413705
18.
ABCC2-mediated biliary transport of 4-glutathionylcyclophosphamide and its contribution to elimination of 4-hydroxycyclophosphamide in rat.
J Pharmacol Exp Ther;
308(3): 1204-12, 2004 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-14617693
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