Patterns of peripartum depression and anxiety during the pre-vaccine COVID-19 pandemic.

BACKGROUND: Pregnant people are vulnerable to new or worsening mental health conditions. This study aims to describe prevalence and course of depression and anxiety symptoms in pregnancy during the pre-vaccine COVID-19 pandemic. METHODS: This is a prospective cohort study of pregnant individuals with known or suspected COVID-19. Participants completed Edinburgh Postnatal Depression Scale (EPDS) and Generalized-Anxiety Disorder-7 (GAD-7) questionnaires, screening tools for depression and anxiety, at 34weeks gestational age, 6-8weeks postpartum, and 6months postpartum. Prevalence of elevated depressive and anxiety symptoms at each visit was described. Univariable logistic regression analysis was used to determine the association between demographic and clinical factors and those with elevated depression or anxiety symptoms. RESULTS: 317 participants were included. The prevalence of elevated antepartum depression symptoms was 14.6%, 10.3%, and 20.6% at 34weeks gestational age, 6-8weeks postpartum, and 6months postpartum, respectively. The rate of elevated anxiety symptoms was 15.1%, 10.0%, and 17.3% at 34weeks gestational age, 6-8weeks postpartum, and 6months postpartum, respectively. A prior history of depression and/or anxiety (p's < 0.03), as well as higher EPDS and GAD-7 scores at enrollment (p's < 0.04) associated with elevated depression and anxiety symptoms throughout pregnancy and the postpartum period. Quarantining during pregnancy was associated with elevated anxiety symptoms at 34weeks gestational age in univariate (P = 0.027) analyses. COVID-19 diagnosis and hospitalization were not associated with elevated depression or anxiety symptoms. CONCLUSIONS: Elevated depression and anxiety symptoms were prevalent throughout pregnancy and the postpartum period, particularly in those with prior depression and/or anxiety and who quarantined. Strategies that target social isolation may mitigate potential adverse consequences for pregnant people, and continued vigilance in recognition of depression and anxiety in pregnancy should be considered.

Exploring the impact of maternal early life adversity on interoceptive sensibility in pregnancy: implications for prenatal depression.

PURPOSE: Pregnancy is a sensitive period of development in adult life characterized by massive changes in physical, emotional, and cognitive function. Such changes may be adaptive, e.g., facilitating adjustment to physical demands, but they may also reflect or contribute to risks inherent to this stage of life, e.g., prenatal depression. One cognitive ability that may undergo change during pregnancy and contribute to mental wellness is interoception - the ability to perceive, integrate, and model sensory information originating from the body. Strong interoceptive abilities are associated with lower rates of depression in non-pregnant adult populations, and interoception is generally weaker in individuals at higher risk for depression, for example, exposure to early life adversity (ELA). In the present online, cross-sectional study, we investigated whether interoception in pregnant women differed based on histories of ELA, in ways that increased their relative risk for prenatal depression symptoms. METHODS: The pregnant individuals were in the second trimester of their first pregnancy and were compared to a group of nulliparous, non-parenting women. RESULTS: Previous exposure to ELA significantly moderated pregnancy-related differences in self-reported interoception (interoceptive sensibility). A further moderated-mediation analysis revealed that the extent to which interoceptive sensibility buffered against depressive symptoms was conditional on ELA exposure, suggesting more ELA is associated with lower interoceptive sensibility during pregnancy, which increased prenatal depression risk. CONCLUSIONS: Together this work suggests that levels of interoception during pregnancy are sensitive to previous adversity exposure. It also suggests that interoceptive-focused interventions for preventing/treating prenatal depressive symptoms in high-risk women may be worth exploring.

The Cost of Avoidance.

As child psychiatrists, it is our job to ask questions, and many of us would say we are really good at it. We work with our patients to open up about their experiences, discussing fear, sadness, hope, and joy. By modeling this ability to open up in the office, we help guide children and adolescents through using other skills rather than avoidance. Although avoidance has its place at times, we help show our patients the connection between anxiety and avoidance. This necessity to embrace and challenge fears can be a difficult skill for our patients and also their families. Children bring forward questions that parents may want to avoid, fearing the answer might be more difficult for the child than the rejection of having the question avoided all together. As someone who works with children with chronic illnesses, this avoidance of the question can in fact increase the fear and anxiety of the child or adolescent. When talking to children, often they will express a greater fear than the reality of the situation because they determine that if their parent is avoiding the question, it must be really bad. This same struggle with avoidance can be true for us as child psychiatrists as well. The necessity to take on roles of leadership or run a team often presents itself, but excuses can come up to help us avoid these roles. We might say we are not properly trained, we did not go into medicine to do those responsibilities, or we are too busy. By avoiding these responsibilities, we are setting ourselves up for more frustration. As teams struggle, we have to follow the lead of others without the same clinical knowledge, which may result in additional errors. We must remember to practice what we preach and to identify the cost of avoidance.

Finding the Time to Reconnect.

Starting in March 2020, we went into a period of collective social isolation that seemed like it would never end. As we mostly stayed in our own spaces, seeing others only by screens or through a distance, we at times lost connections. As we continue to move back to reconnecting and rebuilding our social networks, it represents a time to reflect back on what happened before. We can see the impact that this isolation had on mental health and our ability to reconnect with others post pandemic. Of course, the hope is that going through a pandemic such as this is not something any of us will experience again in our lifetime. That being said, periods of isolation will most likely happen to us again at some point in our lives. It leads to the point of us wondering: how could we do better, and how could we better keep these connections even when physically we are isolated? Although a lot of effort will be poured into how to prevent another infectious disease pandemic, we must not forget the topic of how to avoid another mental health pandemic.

What Makes Us Who We Are?

As child and adolescent psychiatrists, it is our job to identify factors that influence the behaviors seen in front of us. Often the question is asked whether these factors are primarily due to nature or nurture: Is someone born a "bad kid," or are there environmental exposures that lead to less than ideal behaviors? Factors such as racism, poverty, bullying, social isolation, and even where we grow up could play a part in the behaviors seen. This is one of the most rewarding, but at times can be one of the most frustrating, parts of our job as child and adolescent psychiatrists. Hopefully we can explore the factors influencing behaviors seen by the children we work with, highlighting the good in them and the situations that have led to the concerns seen. At the same time, we can become frustrated knowing that some of these factors are difficult for us to change as an individual child and adolescent psychiatrist, such as racism, poverty, inequalities in education, or family support. Bearing witness to these societal issues and their impact on our patients hopefully sparks advocacy efforts toward larger system changes.

Rupture and Repair.

Rupture and repair are key ingredients to connection. When ruptures in relationships occur, which they will, it is important to revisit the situation to work on restoring safety, regulation, attunement, and understanding. Through engaging in this process and providing consistent secure base and safe haven supports, conflicts have the opportunity to heal. Developmentally, the practice of rupture and repair begins during infancy and early childhood, laying the foundation for secure attachment. What happens when ruptures repeatedly occur without repair? How does this impact self-esteem and the narratives children create about themselves as they grow? As you can imagine, repeated rupture without repair can lead to mistrust, cognitive distortions, resentment, and emotional stunting. As child and adolescent psychiatrists, we can help families understand that relationships, like people, can bend without breaking-and that a healthy serving of humble pie can be just what the doctor ordered.

What's in a Name? From Book Forum to Media Forum.

As editors of the Book Forum, we have seen an increased interest in authors writing reviews in other media sources besides books. This is not a surprise as we find more media sources that we go to for information as well as entertainment. On top of that, for better or worse, our patients are spending more of their time on other sources of media besides books. We are often unfamiliar with these media sources and are unable to engage meaningfully with our patients. This can be important in rapport building, which was a consideration when we had people review, for example, the video games Fortnite and Among Us. It can also be important in understanding the safety concerns of a media source, preparing our readership of child and adolescent psychiatrists to talk about controversial, potentially triggering topics with patients (ie, Thirteen Reasons Why). The goal of the Book Forum has always been to introduce child and adolescent psychiatrists to materials that would be important for their education or enjoyment and to understand the materials that our patients may be perusing. In an effort to continue this mission, we worked with Journal staff to rebrand the Book Forum as the Media Forum. We hope that this move will only add to the opportunities you all have as writers and readers, as we still welcome books, but now we welcome movies, TV shows, short videos, articles, video games, and anything else you think would be relevant. As you can see from this month's reviews of books, we continue to encourage reading and the submission of book reviews. We look forward to your suggestions for future reviews.

Lessons Learned From Magna-Tiles.

Have you ever built a spaceship using Magna-Tiles with a 4-year-old child? If not, place this on the top of your to-do list, as there are many lessons hidden within these colorful pieces of plastic. In addition to teaching patience and cooperation, the process of building with a preschooler with big emotions and an underdeveloped prefrontal cortex offers endless opportunities to serve as both a safe haven and a secure base. As each tile is carefully (or not so carefully) placed, you are building more than just a misshapen spaceship; you are reinforcing a foundation of trust and mutual respect. In helping my own 4-year-old daughter build a unicorn-themed spaceship that resembled a tug boat, I cringed when she placed the final tile that would collapse our creative masterpiece. Much to my surprise, instead of disappointment and tears, she erupted into laughter and began the process of building all over again. She reminded me that joy can come from an experience rather than an outcome, that creativity and imagination should be sprinkled daily into the work we do, and that not every spaceship is destined to be out of this world!

The Power of Shared Experience.

The experiences of others can often be used as a motivator, caution tale, point of education, and much more. Parents describe their own experiences to help their children make the right choices, including avoiding some mistakes they might regret. We watch movies and read books about historical figures, actors, athletes, and other famous people to better understand how their experiences shaped the person they became. More recently the growth of influencer culture has led people to watch videos to make decisions based on what the person tells them of their own experience. The difficulty is that many of these experiences have been selectively crafted to fit what makes a good movie or to promote a product.

The Impact of Postpartum Depression on the Early Mother-Infant Relationship during the COVID-19 Pandemic: Perception versus Reality.

Postpartum depression (PPD) can interfere with the establishment of affective bonds between infant and mother, which is important for the cognitive, social-emotional, and physical development of the child. Rates of PPD have increased during the COVID-19 pandemic, likely due to the added stress and limited support available to new parents. The present study examined whether parenting-related stress, perceived bonding impairments, the quality of observed mother-infant interactions, and salivary oxytocin levels differ between depressed and non-depressed mothers, along with differential impacts of COVID-19 on depressed mothers. Participants included 70 mothers (45 depressed, 25 controls) with infants aged 2-6 months. All data were collected remotely to ease participant burden during the pandemic. Depression was associated with experiences of heightened parenting-related stress and bonding difficulties. These differences were not observed during mother-infant interactions or in salivary oxytocin levels. Differences in COVID-19-related experiences were minimal, though depressed mothers rated slightly higher stress associated with returning to work and financial impacts of the pandemic. Findings highlight the importance of early intervention for PPD to mitigate long-term effects on mothers, children, and families. Additionally, they underscore the need for early intervention to support the developing mother-infant dyad relationship during this crucial time.

Study protocol: perinatal mood treatment study.

Perinatal depression (PND) affects up to 20% of women and is associated with significant impairment and disability in affected women. In addition, perinatal depression is associated with broader public health and multigenerational consequences. Innovative approaches are needed to reduce the burden of perinatal depression through identification, tracking, and treatment of depressive symptoms during the perinatal period. This study is a randomized clinical trial comparing the relative efficacy of a multi-tiered system of care, Screening and Treatment of Anxiety and Depression (STAND) to perinatal care delivered by a reproductive psychiatrist in reducing symptoms of depression and anxiety. A sample of 167 individuals was randomized between week 28 of pregnancy and 6 months postpartum. A secondary aim compares the original online therapy intervention used in the first half of the study to a newer online therapy program used in the second half of the study for individuals assigned to the STAND treatment. The study measures, intervention groups, and analysis methods are described, as well as expected implications. The findings from this study may improve the methods for tracking symptom changes over time, monitoring treatment response, and providing personalized care for individuals with PND. As such, this study may improve the lives of patients with PND and their families and lower the related health care costs to society.Trial registration NCT: 9/24/2021NCT direct link: https://www.clinicaltrials.gov/study/NCT05056454?term=NCT05056454&rank=1&a=1 .