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1.

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.

Gudjonsson, Thorkell; Altmeyer, Matthias; Savic, Velibor; Toledo, Luis; Dinant, Christoffel; Grøfte, Merete; Bartkova, Jirina; Poulsen, Maria; Oka, Yasuyoshi; Bekker-Jensen, Simon; Mailand, Niels; Neumann, Beate; Heriche, Jean-Karim; Shearer, Robert; Saunders, Darren; Bartek, Jiri; Lukas, Jiri; Lukas, Claudia.

Cell; 150(4): 697-709, 2012 Aug 17.

Artículo en Inglés | MEDLINE | ID: mdl-22884692

2.

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.

Farrawell, Natalie E; Bax, Monique; McAlary, Luke; McKenna, Jessie; Maksour, Simon; Do-Ha, Dzung; Rayner, Stephanie L; Blair, Ian P; Chung, Roger S; Yerbury, Justin J; Ooi, Lezanne; Saunders, Darren N.

Hum Mol Genet; 32(14): 2386-2398, 2023 07 04.

Artículo en Inglés | MEDLINE | ID: mdl-37220877

3.

Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice.

Van Woerkom, Andries; Harney, Dylan J; Nagarajan, Shilpa R; Hakeem-Sanni, Mariam F; Lin, Jinfeng; Hooke, Matthew; Pilpitel, Tamara; Cooney, Gregory J; Larance, Mark; Saunders, Darren N; Brandon, Amanda E; Hoy, Andrew J.

Am J Physiol Endocrinol Metab; 2024 Apr 24.

Artículo en Inglés | MEDLINE | ID: mdl-38656127

4.

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver.

Nerstedt, Annika; Kurhe, Yeshwant; Cansby, Emmelie; Caputo, Mara; Gao, Lei; Vorontsov, Egor; Ståhlman, Marcus; Nuñez-Durán, Esther; Borén, Jan; Marschall, Hanns-Ulrich; Mashek, Douglas G; Saunders, Darren N; Sihlbom, Carina; Hoy, Andrew J; Mahlapuu, Margit.

J Lipid Res; 61(2): 178-191, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31857389

5.

SOD1^A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.

Farrawell, Natalie E; Lambert-Smith, Isabella; Mitchell, Kristen; McKenna, Jessie; McAlary, Luke; Ciryam, Prajwal; Vine, Kara L; Saunders, Darren N; Yerbury, Justin J.

J Cell Sci; 131(11)2018 06 12.

Artículo en Inglés | MEDLINE | ID: mdl-29748379

6.

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

Ciryam, Prajwal; Lambert-Smith, Isabella A; Bean, Daniel M; Freer, Rosie; Cid, Fernando; Tartaglia, Gian Gaetano; Saunders, Darren N; Wilson, Mark R; Oliver, Stephen G; Morimoto, Richard I; Dobson, Christopher M; Vendruscolo, Michele; Favrin, Giorgio; Yerbury, Justin J.

Proc Natl Acad Sci U S A; 114(20): E3935-E3943, 2017 05 16.

Artículo en Inglés | MEDLINE | ID: mdl-28396410

7.

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

Kennedy, Sean P; Han, Jeremy Z R; Portman, Neil; Nobis, Max; Hastings, Jordan F; Murphy, Kendelle J; Latham, Sharissa L; Cadell, Antonia L; Miladinovic, Dushan; Marriott, Gabriella R; O'Donnell, Yolande E I; Shearer, Robert F; Williams, James T; Munoz, Amaya Garcia; Cox, Thomas R; Watkins, D Neil; Saunders, Darren N; Timpson, Paul; Lim, Elgene; Kolch, Walter; Croucher, David R.

Breast Cancer Res; 21(1): 43, 2019 03 21.

Artículo en Inglés | MEDLINE | ID: mdl-30898150

8.

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.

Liu, Ling; Phua, Yu Wei; Lee, Rachel S; Ma, Xiuquan; Jenkins, Yiping; Novy, Karel; Humphrey, Emily S; Chan, Howard; Shearer, Robert; Ong, Poh Chee; Dai, Weiwen; Saunders, Darren N; Lucet, Isabelle S; Daly, Roger J.

J Biol Chem; 291(41): 21571-21583, 2016 Oct 07.

Artículo en Inglés | MEDLINE | ID: mdl-27531744

9.

Systematic approaches to identify E3 ligase substrates.

Iconomou, Mary; Saunders, Darren N.

Biochem J; 473(22): 4083-4101, 2016 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-27834739

10.

Walking the tightrope: proteostasis and neurodegenerative disease.

Yerbury, Justin J; Ooi, Lezanne; Dillin, Andrew; Saunders, Darren N; Hatters, Danny M; Beart, Philip M; Cashman, Neil R; Wilson, Mark R; Ecroyd, Heath.

J Neurochem; 137(4): 489-505, 2016 05.

Artículo en Inglés | MEDLINE | ID: mdl-26872075

11.

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

Röring, Michael; Herr, Ricarda; Fiala, Gina J; Heilmann, Katharina; Braun, Sandra; Eisenhardt, Anja E; Halbach, Sebastian; Capper, David; von Deimling, Andreas; Schamel, Wolfgang W; Saunders, Darren N; Brummer, Tilman.

EMBO J; 31(11): 2629-47, 2012 May 30.

Artículo en Inglés | MEDLINE | ID: mdl-22510884

12.

Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives.

Shearer, Robert F; Saunders, Darren N.

Genes Cells; 20(1): 1-10, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25307957

13.

Regulation of primary cilia formation by the ubiquitin-proteasome system.

Shearer, Robert F; Saunders, Darren N.

Biochem Soc Trans; 44(5): 1265-1271, 2016 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-27911708

14.

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.

Ong, Su Sien; Goktug, Asli N; Elias, Ayesha; Wu, Jing; Saunders, Darren; Chen, Taosheng.

Biochem J; 459(1): 193-203, 2014 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-24438055

15.

Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer.

Cochran, Blake J; Croucher, David R; Lobov, Sergei; Saunders, Darren N; Ranson, Marie.

J Biol Chem; 286(27): 24467-75, 2011 Jul 08.

Artículo en Inglés | MEDLINE | ID: mdl-21606492

16.

Proteostasis impairment and ALS.

Lambert-Smith, Isabella A; Saunders, Darren N; Yerbury, Justin J.

Prog Biophys Mol Biol; 174: 3-27, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-35716729

17.

Modulation of myocardin function by the ubiquitin E3 ligase UBR5.

Hu, Guoqing; Wang, Xiaobo; Saunders, Darren N; Henderson, Michelle; Russell, Amanda J; Herring, B Paul; Zhou, Jiliang.

J Biol Chem; 285(16): 11800-9, 2010 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-20167605

18.

Backlogged system in Australia shuts out new investigators.

Saunders, Darren.

Nature; 458(7236): 281, 2009 Mar 19.

Artículo en Inglés | MEDLINE | ID: mdl-19295584

19.

Cancer in the news: Bias and quality in media reporting of cancer research.

Amberg, Amanda; Saunders, Darren N.

PLoS One; 15(11): e0242133, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-33166352

20.

Mercury, methylmercury and long-chain polyunsaturated fatty acids in selected fish species and comparison of approaches to risk-benefit analysis.

Cressey, Peter; Miles, Geoff; Saunders, Darren; Pearson, Andrew J.

Food Chem Toxicol; 146: 111788, 2020 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-33011354

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