RESUMO
BACKGROUND: Priapism is a prolonged stimulation with painful, persistent penile erection unaccompanied by sexual desire. It is a rare but serious urological emergency. Risperidone is an atypical antipsychotic widely prescribed for the treatment of behavior problems in children with autism spectrum disorder. It seems associated with priapism in children. CASE PRESENTATION: We present a case of a 12-year-old Moroccan boy diagnosed with autism spectrum disorder who developed priapism while on an existing regimen of risperidone, and we report the treatment decisions that followed. CONCLUSIONS: Clinicians who prescribe risperidone should be aware of the possibility of this rare complication in their patients. Information about this possible side effect and instructions regarding appropriate response should be made available to caregivers of those in the at-risk group of young patients.
Assuntos
Antipsicóticos/efeitos adversos , Transtorno do Espectro Autista/tratamento farmacológico , Priapismo/induzido quimicamente , Risperidona/efeitos adversos , Antipsicóticos/uso terapêutico , Criança , Humanos , Masculino , Marrocos , Risperidona/uso terapêuticoAssuntos
Transtorno Bipolar/diagnóstico , Hospitalização/estatística & dados numéricos , Transtornos Mentais/diagnóstico , Adolescente , Adulto , Transtorno Bipolar/fisiopatologia , Estudos Transversais , Diagnóstico Tardio , Feminino , Humanos , Masculino , Transtornos Mentais/fisiopatologia , Pessoa de Meia-Idade , Fatores de Tempo , Adulto JovemAssuntos
Anticonvulsivantes/efeitos adversos , Antipsicóticos/efeitos adversos , Síndrome Maligna Neuroléptica/etiologia , Adolescente , Adulto , Amissulprida , Benzodiazepinas/efeitos adversos , Carbamazepina/efeitos adversos , Quimioterapia Combinada , Feminino , Humanos , Masculino , Síndrome Maligna Neuroléptica/diagnóstico , Olanzapina , Sulpirida/efeitos adversos , Sulpirida/análogos & derivados , Ácido Valproico/efeitos adversosRESUMO
BACKGROUND: Epidemiological studies of schizophrenia suggest that this disorder has a substantial genetic component. Cognitive and social abilities, as well as the volumes of brain regions involved in emotion processing, have been found to be distributed along a continuum when comparing patients, siblings and controls, with siblings showing intermediate scores. AIMS: To establish whether facial expression recognition is impaired in unaffected siblings of patients. METHOD: Emotion and gender recognition were evaluated in a three-group pre-post study design in drug-naive patients with first-episode schizophrenia (n=40) and their unaffected siblings (n=30) compared with controls (n=26). RESULTS: Patients and their healthy siblings showed impaired emotion recognition but normal gender recognition compared with controls. Patients'performance did not improve despite effective clinical stabilisation. CONCLUSIONS: Impaired performance in healthy siblings and time stability in patients provides evidence of impairment of facial emotion recognition as an actual phenotype of schizophrenia.