Detalhe da pesquisa
1.
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.
Cell
; 158(3): 534-48, 2014 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25018104
2.
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
Cell
; 138(3): 562-75, 2009 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19665977
3.
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
Nat Chem Biol
; 17(11): 1148-1156, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34556859
4.
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
Am J Physiol Lung Cell Mol Physiol
; 322(4): L564-L580, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35170357
5.
Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.
Int J Mol Sci
; 21(17)2020 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32878237
6.
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
Nat Chem Biol
; 8(12): 982-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23086298
7.
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome.
J Exp Med
; 217(11)2020 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32725126
8.
Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.
ACS Chem Biol
; 14(12): 2595-2605, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31609569
9.
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
PLoS One
; 14(1): e0209824, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30625178
10.
Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Cancer Res
; 79(24): 6190-6203, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31672843
11.
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
J Med Chem
; 50(8): 1983-7, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17367123
12.
Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis.
J Clin Invest
; 127(10): 3675-3688, 2017 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28872461
13.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes.
Cell Metab
; 25(4): 883-897.e8, 2017 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28380378
14.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064063
15.
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.
ACS Chem Biol
; 11(8): 2195-205, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27227314
16.
Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.
Chem Biol
; 11(10): 1361-72, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15489163
17.
Chiral N-Acyl-tert-butanesulfinamides: The "Safety-Catch" Principle Applied to Diastereoselective Enolate Alkylations.
J Org Chem
; 64(15): 5472-5478, 1999 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674609
18.
From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling.
Angew Chem Int Ed Engl
; 40(17): 3152-3155, 2001 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29712061
19.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes.
Cell Metab
; 25(5): 1207, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28467938
20.
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Cell Metab
; 16(2): 250-64, 2012 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22883233