Detalhe da pesquisa
1.
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.
Eur Respir J
; 61(4)2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36549711
2.
TGF-ß induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.
Nat Immunol
; 13(1): 77-85, 2011 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22080920
3.
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.
Immunity
; 31(4): 632-42, 2009 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19833088
4.
Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production.
J Immunol
; 191(4): 1536-46, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23851689
5.
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
J Immunol
; 188(8): 4023-31, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22403444
6.
Gasdermins assemble; recent developments in bacteriology and pharmacology.
Front Immunol
; 14: 1173519, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37266429
7.
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Nat Commun
; 12(1): 3364, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34099649
8.
Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.
J Immunol
; 181(7): 4815-24, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18802085
9.
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Commun Biol
; 3(1): 140, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32198438
10.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31265286
11.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
12.
Use of RIP1 Kinase Small-Molecule Inhibitors in Studying Necroptosis.
Methods Mol Biol
; 1857: 109-124, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30136235
13.
RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.
Cancer Cell
; 34(5): 757-774.e7, 2018 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423296
14.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27109867
15.
Receptor-interacting protein 1 kinase inhibition therapeutically ameliorates experimental T cell-dependent colitis in mice.
Cell Death Dis
; 11(4): 220, 2020 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32249785
16.
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.
PLoS One
; 10(5): e0127083, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25965667
17.
RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.
Cancer Cell
; 38(4): 585-590, 2020 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33049209