1.
Bioorg Med Chem Lett
; 19(23): 6548-51, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19854648
RESUMO
A series of indeno[1,2-c]pyrazoles were discovered to be the first known inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. The synthesis, structure-activity relationship profile, and in-vitro pharmacological characterization of this inaugural series of HRI kinase inhibitors are detailed.