RESUMO
INTRODUCTION: Myositis is an autoimmune disease characterised by proximal muscle weakness. AIM: The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies. METHOD: Antibodies were detected using immunoblot and immunoprecipitation. RESULTS: Of the 330 patients with myositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease. CONCLUSIONS: Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy.
Assuntos
Autoanticorpos/sangue , Dermatomiosite/imunologia , Debilidade Muscular/imunologia , Adulto , Dermatomiosite/complicações , Dermatomiosite/fisiopatologia , Feminino , Humanos , Immunoblotting , Imunoprecipitação , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Összefoglaló. Az atkák alosztálya heterogén csoport. Az eltéro megjelenésu és életformájú atkák növényeken, állatokon és embereken is képesek különféle megbetegedéseket okozni, melyek csípés, táplálkozás, élosködés, vektorként terjesztett kórokozók által valósulhatnak meg. Az atkák okozta betegségek a lokális, spontán szuno csípéstol egészen a sokszervi elégtelenséget okozó fertozo betegségig széles skálán mozognak. Munkánk során az atkafélék által okozott humán megbetegedések elofordulását, klinikai megjelenését, differenciáldiagnosztikáját, kezelését és közegészségügyi jelentoségét mutatjuk be. Orv Hetil. 2021; 162(36): 1430-1437. Summary. The Acari subclass is a heterogeneous group. They have different appearance and lifestyle. They can cause different diseases on plants, in animals and in humans. These illnesses can be caused by their bites, nutrition, parasitism and by their endoparasites. The diseases move on a wide scale from a local, spontaneously disappearing bite to an infection caused multiorgan failure. We would like to summarize the Acari-caused human diseases' incidence, clinical symptoms, diagnostics, differential diagnostics, treatments and public health importance. Orv Hetil. 2021; 162(36): 1430-1437.