Detalhe da pesquisa
1.
GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.
J Biol Chem
; 297(2): 100928, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274316
2.
Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.
J Am Chem Soc
; 140(3): 932-939, 2018 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29232121
3.
CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma.
J Chem Inf Model
; 56(6): 1063-77, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27149958
4.
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Bioorg Med Chem
; 23(21): 7000-6, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26455654
5.
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.
Bioorg Med Chem Lett
; 21(6): 1582-7, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21349710
6.
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.
Bioorg Med Chem Lett
; 21(6): 1588-92, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21349711
7.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
J Med Chem
; 64(18): 13780-13792, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34510892
8.
Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.
Bioorg Med Chem Lett
; 20(19): 5695-700, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20801653
9.
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.
Bioorg Med Chem Lett
; 20(2): 618-22, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20006499
10.
Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ.
ACS Med Chem Lett
; 11(7): 1386-1391, 2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32676144
11.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551024
12.
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Bioorg Med Chem Lett
; 19(19): 5760-3, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19703773
13.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ACS Med Chem Lett
; 10(11): 1518-1523, 2019 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749904
14.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31265286
15.
Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Bioorg Med Chem Lett
; 18(1): 28-33, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18053714
16.
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.
Bioorg Med Chem Lett
; 18(1): 23-7, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18054228
17.
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem
; 13(7): 672-677, 2018 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29399991
18.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344914
19.
Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.
J Med Chem
; 50(7): 1546-57, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17338508
20.
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
Eur J Med Chem
; 112: 252-257, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26900657