Detalhe da pesquisa
1.
Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension.
J Pharmacol Exp Ther
; 360(2): 267-279, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27927914
2.
Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg Med Chem Lett
; 27(3): 413-419, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28041831
3.
Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg Med Chem Lett
; 26(4): 1124-9, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26821821
4.
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.
Bioorg Med Chem Lett
; 26(12): 2855-2860, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27146606
5.
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.
Bioorg Med Chem Lett
; 21(9): 2641-5, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295475
6.
Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.
Bioorg Med Chem Lett
; 21(15): 4533-9, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733690
7.
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 20(2): 571-5, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969453
8.
Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method.
Bioorg Med Chem Lett
; 20(12): 3703-7, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20472432
9.
Selective Inhibitors of G2019S-LRRK2 Kinase Activity.
J Med Chem
; 63(23): 14821-14839, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33197196
10.
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 19(20): 5864-8, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19758802
11.
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design.
Bioorg Med Chem Lett
; 19(3): 773-7, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19111460
12.
2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(16): 4486-90, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18672365
13.
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 891-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18180159
14.
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662872
15.
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
J Med Chem
; 58(4): 1669-90, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671290
16.
Design, synthesis, and biological evaluation of substituted 2-cyclohexyl-4-phenyl-1H-imidazoles: potent and selective neuropeptide Y Y5-receptor antagonists.
J Med Chem
; 47(9): 2318-25, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084130
17.
Discovery of potent, selective chymase inhibitors via fragment linking strategies.
J Med Chem
; 56(11): 4465-81, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659209
18.
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
J Med Chem
; 55(16): 7114-40, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22803959
19.
Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
J Med Chem
; 54(12): 4187-206, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21618986
20.
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
J Med Chem
; 53(8): 3330-48, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20307063